Analysis of type Th1 and Th2 cytokines in patients with prostate cancer

Background: It has been proposed that a dysregulation in the balance between type Th1 (IL-2, IFN-gamma) and type Th2 (IL-4, IL-10) cytokines may be implicated in the development of cancer.

Methods: We determined the expression of IL-2, IL-4, IL-10, and IFN-gamma in CD4 and CD8 lymphocytes by flow cytometry in 12 patients with prostate cancer and in 7 healthy subjects. In addition to the basal expression of these cytokines, their expression was also determined, following stimulation of lymphocytes with PMA (phorbol 12-mystirate 13 acetate) and ionomycin.

Results: The basal expression of cytokines was scarce, while following stimulation this increased markedly. On the other hand, there was a dysregulation in the balance between Th1 and Th2 lymphocytes in patients with prostate cancer. To this effect, in relation to healthy subjects, we observed an increase in IL-10 expression and a decrease in IL-2 expression.

Conclusions: The disequilibrium observed in the balance between type Th1 and type Th2 cytokines may be implicated in the evolution of neoplastic disease.

pubmed.ncbi.nlm.nih.gov/109...

Effects of Th1/Th2 on tumor progression

Naive T cells become Th1 cells or Th2 cells, following the stimulation by different factors. In Th1 immunity, cells produce pro-inflammatory cytokines, such as interleukin-2 (IL2), interferon-gamma (IFN-γ), and tumor necrosis factor-beta (TNF-β). In Th2 immunity, cells produce antiinflammatory cytokines, such as IL-4, IL-5, IL-6, IL-10, and IL-13. In normal circumstances, Th1 immunity and Th2 immunity approach a balance. But, the presence of tumor cells disrupts this balance. This occuring increased Th2 immunity and decreased Th1 immunity, because of down-regulation of adaptive immunity. This eventually leads to tumor progression. However, if Th1 immunity becomes predominant, this stimulation of immunity can lead to tumor regression. In prostate cancer patients IL-2 was low (Th1) and IL-10 high (Th2).

Are You Th1 or Th2 Dominant?

The following have been associated with Th2 dominance in studies:

-- Cancers

-- Food allergies

-- Seasonal allergies

-- Airway constriction

-- Asthma

-- Nasal drip

-- Mucus

-- Eczema (Dermatitis)

-- Hay fever (Allergic rhinitis)

-- Increased stomach acidity or GERD

-- Histamine intolerance

-- Hives (Urticaria)

-- Chronic Fatigue Syndrome

-- Autism

-- Uveitis

-- Grave’s disease

-- Sjogren’s

-- Oral Lichen Planus

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Top Factors that Balance the Immune System (Lower Th2)

1- Sun/UVB light

2- Probiotics

3- Glutathione/NAC

4- Licorice

5- Gynostemma

6- Ginger

7- Reishi

8- Tinospora

9- Quercetin

10- Astragalus

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Again to summarize in one sentence... Eating plant based foods esp. Red Onions, Garlic, Ginger, Berries and Lying in Sun for an hour every day....Can keep the balance in favor of Th 1.