Novel COVID-19 Vaccine Shows Promise for People with Leukemia and Lymphoma

[bennevisplace]

Following on from healthunlocked.com/cllsuppo... here is news of a Covid19 "T-cell activator" vaccine, which has shown promise in Phase 1/2 clinical trial subjects with haematological malignancies including CLL. The research team are now “looking for industry partners for the further development of CoVac-1 and hope to begin a phase III approval trial toward the end of this year".

ARTICLE

insideprecisionmedicine.com...

EXTRACTS

"German researchers have created a new vaccine against SARS-CoV-2... that induces a T cell immune response in a high proportion of patients with leukemia and lymphoma... at high risk for severe COVID-19 because... they cannot mount sufficient humoral, i.e., antibody-mediated, immune responses after vaccination with mRNA and other currently approved COVID-19 vaccines".

"The researchers... proceeded to the current Phase I/II trial among 54 people with B cell deficiencies. Of these, four participants had a congenital B cell deficiency and the remainder had hematologic malignancies, most commonly chronic lymphocytic leukemia (n=12), mantle cell lymphoma (n=10), and follicular lymphoma (n=7). The majority (87%) of participants had been previously vaccinated with approved COVID-19 vaccines and none had developed an immune response".

"In terms of immunogenicity, 62% of participants developed a SARS-CoV-2-specific T cell response by day 14, and by day 28 this proportion increased to 86%. Tandler said that the induced CD4+ T cells “displayed a desired multifunctional phenotype” that was positive for cytokines such as interleukin 2, tumor necrosis factor, and interferon gamma. “This resembles the phenotype after natural infection,” she said. In addition, the researchers found that the T cell responses exceeded those of mRNA vaccinated immunocompromised individuals".

[annmcgowan]

Great news thank you for letting us know.Ann

[hopefulbunny]

Thanks for info, sounds promising. 🌱

[Fran57]

That’s very encouraging news. Thank you.Stay safe,

Fran 😷

[CaptRon1976]

I look forward to hearing more about this innovation!

[bennevisplace in reply to CaptRon1976]

Yes, look out for the publication of the phase 1-2 study, as recently presented at the American Association of Cancer Research. With an industry partner they hope to go into phase 3 later this year, so maybe we will see more data in 2023. That's fine, it's a long game we must play against SARS-like viruses.