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Targeted Drugs and Need for Genetic Testing??
This is one of today's posts in Practice Update: STORY OF THE WEEK Published in Metastatic Breast Cancer · April 08, 2022 .... CDK4/6 Inhibitor Outcomes in Patients With Advanced Breast Cancer With Germline Pathogenic Variants in DNA Repair–Related Genes TAKE-HOME MESSAGE "This retrospective study
This is one of today's posts in Practice Update: STORY OF THE WEEK Published in Metastatic Breast Cancer · April 08, 2022 .... CDK4/6 Inhibitor Outcomes in Patients With Advanced Breast Cancer With Germline Pathogenic Variants in DNA Repair–Related Genes TAKE-HOME MESSAGE "This retrospective study
Hazelgreen
in
SHARE Metastatic Breast Cancer
2 years ago
Experience with the drug Xtandi
Scans revealed no
metastasis
. Treatment was external radiation and Lupron injections. PSA reading on 6/19/2018 was 0.32 with the latest reading 01/12/2022 of 4.78. A suggested treatment involves the drug Xtandi. Does anyone have experience with this drug. Thanks
Scans revealed no
metastasis
. Treatment was external radiation and Lupron injections. PSA reading on 6/19/2018 was 0.32 with the latest reading 01/12/2022 of 4.78. A suggested treatment involves the drug Xtandi. Does anyone have experience with this drug. Thanks
cedaral
in
Prostate Cancer Network
3 years ago
Amg757 trial
His bone
metastasis
is spreading after 18 rounds of Cisplatin and Etoposide last year and this year he’s on Docataxel his 5 th of 6, and it doesn’t seem to be effective in reducing the bone Mets. Any info is appreciated. Thank you!
His bone
metastasis
is spreading after 18 rounds of Cisplatin and Etoposide last year and this year he’s on Docataxel his 5 th of 6, and it doesn’t seem to be effective in reducing the bone Mets. Any info is appreciated. Thank you!
Jzner
in
Advanced Prostate Cancer
3 years ago
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Sick again
So every month since I had Covid in December I’ve been sick with something. I had a UTI then the reaction to the new Faslodex and now I’m home sick with the worst cold ever. I don’t know if this is from stress or just my immune system saying quit your job. Anyone have this experience?
So every month since I had Covid in December I’ve been sick with something. I had a UTI then the reaction to the new Faslodex and now I’m home sick with the worst cold ever. I don’t know if this is from stress or just my immune system saying quit your job. Anyone have this experience?
Puppy_love
in
SHARE Metastatic Breast Cancer
2 years ago
Anyone on Afinitor ?
Looks like a drug change is in my future. I have been on Ibrance for nearly 6 years and my onc is taking me off it...because of progression... I have had the Ibrance in 3 different combos , the last being with Faslodex for the past 2 years. But once again there is progression and we will be making
Looks like a drug change is in my future. I have been on Ibrance for nearly 6 years and my onc is taking me off it...because of progression... I have had the Ibrance in 3 different combos , the last being with Faslodex for the past 2 years. But once again there is progression and we will be making
caw517
in
SHARE Metastatic Breast Cancer
2 years ago
No Evidence of Disease!!
Hello. I read often but seldom post. I was diagnosed with MBC in late January 2021. Have been in Ibrance 125 and Faslodex since February 2021. My mets are in my liver only. I have been asymptomatic from the beginning (MBC found in scan for another issue). I see my oncologist monthly and like her
Hello. I read often but seldom post. I was diagnosed with MBC in late January 2021. Have been in Ibrance 125 and Faslodex since February 2021. My mets are in my liver only. I have been asymptomatic from the beginning (MBC found in scan for another issue). I see my oncologist monthly and like her
1711JPD
in
SHARE Metastatic Breast Cancer
2 years ago
CT exam revealed endometrium thickness and biopsy confirmed the endometrium cancer. I have MBC
Hi everyone, I need your help. My last CT revealed the endometrium thickness 20 mm. I was referred to the gynecologist for further evaluation. I am very nervous and anxious. I was on tamoxifen for almost three months but finished it in October. I am on Xeloda now Please share your experience if you
Hi everyone, I need your help. My last CT revealed the endometrium thickness 20 mm. I was referred to the gynecologist for further evaluation. I am very nervous and anxious. I was on tamoxifen for almost three months but finished it in October. I am on Xeloda now Please share your experience if you
Cureforever
in
SHARE Metastatic Breast Cancer
2 years ago
New nodules?
Been on Ibrance and Arimidex for 30 cycles for lung
metastasis
found in May of 2019. I will see oncologist next Tuesday to hear his opinion. Not sure whether to freak or be settled that no activity seen on scan. Opinions?
Been on Ibrance and Arimidex for 30 cycles for lung
metastasis
found in May of 2019. I will see oncologist next Tuesday to hear his opinion. Not sure whether to freak or be settled that no activity seen on scan. Opinions?
Beattheodds
in
SHARE Metastatic Breast Cancer
3 years ago
Clorgyline & MAOA redux. {Treatment-Induced Neuroendocrine Prostate Cancer [NEPC].}
"Emerging evidence indicates that elevated monoamine oxidase A (MAOA) contribute to the proliferation, cell stemness, and bone
metastasis
in PCa." "Here, we generated an enzalutamide-induced NED cell model to assess the role of MAOA during NED.
"Emerging evidence indicates that elevated monoamine oxidase A (MAOA) contribute to the proliferation, cell stemness, and bone
metastasis
in PCa." "Here, we generated an enzalutamide-induced NED cell model to assess the role of MAOA during NED.
pjoshea13
in
Advanced Prostate Cancer
2 years ago
Zytiga vs Xtandi
PSMA found
metastasis
on the sacrum and multiple lymph nodes in pelvic and abdominal area. Started Lupron in October and radiation therapy in January 2022. One oncologist likes Zytiga over Xtandi and the other one likes Xtandi over Zytiga.
PSMA found
metastasis
on the sacrum and multiple lymph nodes in pelvic and abdominal area. Started Lupron in October and radiation therapy in January 2022. One oncologist likes Zytiga over Xtandi and the other one likes Xtandi over Zytiga.
TnRebel62
in
Advanced Prostate Cancer
2 years ago
Lycopene, Heat, Magnets
I learned of my prostate cancer
metastasis
about ten years ago in 2012, which was four years after radiation therapy to my prostate in 2008, following a urinary blockage and biopsy Gleason 8. I chose RT over surgical as my mets were microscopic, confined to prostate.
I learned of my prostate cancer
metastasis
about ten years ago in 2012, which was four years after radiation therapy to my prostate in 2008, following a urinary blockage and biopsy Gleason 8. I chose RT over surgical as my mets were microscopic, confined to prostate.
NecessarilySo
in
Advanced Prostate Cancer
2 years ago
Anyone Having to change to Verzenio
Hi Ladies, My PET shows bone only disease is stable but markers were up and I have this lymph node in neck that is bulging again. So we quickly changed from Ibrance/ faslodex to Verzenio/ aromasin. Onc says she is trying to get more time( just 18 months so far) out of the CDK 4-6 class before the rear
Hi Ladies, My PET shows bone only disease is stable but markers were up and I have this lymph node in neck that is bulging again. So we quickly changed from Ibrance/ faslodex to Verzenio/ aromasin. Onc says she is trying to get more time( just 18 months so far) out of the CDK 4-6 class before the rear
Bettybuckets
in
SHARE Metastatic Breast Cancer
2 years ago
Overall survival (OS) & (MFS) in men with biochemical relapse (BCR) after radical prostatectomy / defer ADT treatment til metastatic
Methods: Retrospective review of men who underwent RP from1983 - 2014 within Johns Hopkins and the Center for Prostate Disease Research Multi-Center National Database, developed BCR and did not receive ADT until
metastasis
.
Methods: Retrospective review of men who underwent RP from1983 - 2014 within Johns Hopkins and the Center for Prostate Disease Research Multi-Center National Database, developed BCR and did not receive ADT until
metastasis
.
George71
in
Advanced Prostate Cancer
2 years ago
I’m Allergic to the Preservatives in the generic faslodex and I can’t get approved for a Faslodex by Astra Zeneca. What then? 😭😭😭😭scared
Does anyone have this problem ? What advice , I can’t see straight with all the phone calls I have made and got nowhere . I have Florida blue . They turned me down for a medically necessary drug to keep me alive , the picture below is now , the injection was 5 weeks ago Tuesday . They were all welts
Does anyone have this problem ? What advice , I can’t see straight with all the phone calls I have made and got nowhere . I have Florida blue . They turned me down for a medically necessary drug to keep me alive , the picture below is now , the injection was 5 weeks ago Tuesday . They were all welts
Ycats277
in
SHARE Metastatic Breast Cancer
2 years ago
Verzenio causing pain in joins, taking a break and now NO the pain!
Im interested to hear the follow up to your break from verzenio. I too had a week break and the horrible joint pain and neuropathy went away! Was particularly bad in hands and feet. Pain level 8-9! Rheumatologist gave me voltarian pills 75mg and oncologist took we off the Verzenio. Next day pain at
Im interested to hear the follow up to your break from verzenio. I too had a week break and the horrible joint pain and neuropathy went away! Was particularly bad in hands and feet. Pain level 8-9! Rheumatologist gave me voltarian pills 75mg and oncologist took we off the Verzenio. Next day pain at
2019artist
in
SHARE Metastatic Breast Cancer
2 years ago
PET scan results
My PET scan results came back good. I have been on Ibrance 100mg and Letrozole for 5 years. I was stage 4 at initial diagnosis. I still have the tumor and it appears to have progressed a little in 6 months (4.9-5.3) my oncologist wants to look at me having surgery, I have one leison on my achetableum
My PET scan results came back good. I have been on Ibrance 100mg and Letrozole for 5 years. I was stage 4 at initial diagnosis. I still have the tumor and it appears to have progressed a little in 6 months (4.9-5.3) my oncologist wants to look at me having surgery, I have one leison on my achetableum
Gmaoftriplets
in
SHARE Metastatic Breast Cancer
2 years ago
Xeloda Experiences Please?
My wife is starting to show progression on Talzenna so we’re about to start Xeloda as monotherapy, 1,000mg twice a day. Probably will start with 2 weeks on, one week off. If toxicity becomes an issue we’ll likely try one week on one week off. The literature and studies seem to be all over the place
My wife is starting to show progression on Talzenna so we’re about to start Xeloda as monotherapy, 1,000mg twice a day. Probably will start with 2 weeks on, one week off. If toxicity becomes an issue we’ll likely try one week on one week off. The literature and studies seem to be all over the place
Half-Full
in
SHARE Metastatic Breast Cancer
2 years ago
Study Supports Longer ADT Use With Radiation for High-Risk Prostate Cancer
In RADAR, prolonged ADT significantly improved
metastasis
-free survival by 44% for patients receiving EBRT+BT but showed no benefit for patients receiving EBRT only. In DART, patients receiving 28 months of ADT and EBRT alone had a significant 63% improvement in
metastasis
-free survival.
In RADAR, prolonged ADT significantly improved
metastasis
-free survival by 44% for patients receiving EBRT+BT but showed no benefit for patients receiving EBRT only. In DART, patients receiving 28 months of ADT and EBRT alone had a significant 63% improvement in
metastasis
-free survival.
Graham49
in
Advanced Prostate Cancer
3 years ago
So glad I found this site
Diagnosed with BC when I was 46, bi lat mastectomy, chemo and tamoxifen. Mets to spine this year after 25 years cancer free. On letrozole and finished radiation. Trying to decide if I really want to take verzenio now or wait a while. The side effects look awful.. I suppose we all debate quality of life
Diagnosed with BC when I was 46, bi lat mastectomy, chemo and tamoxifen. Mets to spine this year after 25 years cancer free. On letrozole and finished radiation. Trying to decide if I really want to take verzenio now or wait a while. The side effects look awful.. I suppose we all debate quality of life
Peggypilot
in
SHARE Metastatic Breast Cancer
2 years ago
Xeloda and tumor markers
Hi everyone, I am on Xeloda now for 6 months. The Pet CT showed some improvement in bones and liver but showed some obstruction in the ureter and thickness in the endometrium. I am going through additional tests now. In my blood test the tumor markers went up from 50th to 70th Another one from 5
Hi everyone, I am on Xeloda now for 6 months. The Pet CT showed some improvement in bones and liver but showed some obstruction in the ureter and thickness in the endometrium. I am going through additional tests now. In my blood test the tumor markers went up from 50th to 70th Another one from 5
Cureforever
in
SHARE Metastatic Breast Cancer
2 years ago
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