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Meta analysis of Eastern Cooperative Oncology Group(ECOG) PS predicts OS regardless of category, previous chemotherapy, and mPC population
”Overall, 75 studies, comprising 32,298 patients, were included. Most studies (72/75) included patients with mCRPC. Higher ECOG PS was associated with a significant increase in mortality risk, with the highest estimate observed among patients with mCRPC with an ECOG PS of ≥2 versus <2 (hazard ratio [
”Overall, 75 studies, comprising 32,298 patients, were included. Most studies (72/75) included patients with mCRPC. Higher ECOG PS was associated with a significant increase in mortality risk, with the highest estimate observed among patients with mCRPC with an ECOG PS of ≥2 versus <2 (hazard ratio [
Graham49
in
Advanced Prostate Cancer
5 months ago
SOS for advice please
In in bad shape can’t stand erect pain all the time compression fractures up & down lumbar to thoracic. It’s been about 3 years in total 11 compression fractures. I’ve had 3 Kyphoplasty’s but have refused any of the pharmaceutical treatments prescribed for bone density issues; tried and can’t/don’t
In in bad shape can’t stand erect pain all the time compression fractures up & down lumbar to thoracic. It’s been about 3 years in total 11 compression fractures. I’ve had 3 Kyphoplasty’s but have refused any of the pharmaceutical treatments prescribed for bone density issues; tried and can’t/don’t
Lisannn
in
Osteoporosis Support
5 months ago
Chronic Discomfort
Hello, please see my profile for background info on my dad. I was just curious if it is expected with my dad's condition for him to be in what seems like chronic discomfort in his prostate region. It does "come and go" as he says but seems like lately more often than not he is "uncomfortable" as he
Hello, please see my profile for background info on my dad. I was just curious if it is expected with my dad's condition for him to be in what seems like chronic discomfort in his prostate region. It does "come and go" as he says but seems like lately more often than not he is "uncomfortable" as he
Juju0713
in
Advanced Prostate Cancer
5 months ago
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BRCA2- is it the devil or not??
I have been researching about BRCA2 as my husband has this . The more I study about this the scarier it seems, is this wrong. It says that men with BRCA2 are more resistant to treatments and earlier than men that are not. Does this mean my husband most likely will become castrate resistant sooner because
I have been researching about BRCA2 as my husband has this . The more I study about this the scarier it seems, is this wrong. It says that men with BRCA2 are more resistant to treatments and earlier than men that are not. Does this mean my husband most likely will become castrate resistant sooner because
positive-thinking
in
Advanced Prostate Cancer
5 months ago
Third line chemotherapy, Caelyx
so, have started Caelyx every 4 weeks as carboplatin and paclitaxel and Niraparib have stopped working. Surgery to remove peritoneum and resection liver not an option. Does anyone have experience of just Caelyx? Is it effective on its own? Thankyou
so, have started Caelyx every 4 weeks as carboplatin and paclitaxel and Niraparib have stopped working. Surgery to remove peritoneum and resection liver not an option. Does anyone have experience of just Caelyx? Is it effective on its own? Thankyou
Skyeplus
in
My Ovacome
5 months ago
Reaction to docetaxel twice now.
second cycle of docetaxel and the same reaction. Pelvic pain, flushing, muzzy head and head ache. Great response from the team again and feeling better pretty quickly. Last time they tried again and it went through okay. Had meds to mitigate but not prevented a reaction. They aren’t go to try the infusion
second cycle of docetaxel and the same reaction. Pelvic pain, flushing, muzzy head and head ache. Great response from the team again and feeling better pretty quickly. Last time they tried again and it went through okay. Had meds to mitigate but not prevented a reaction. They aren’t go to try the infusion
FortyWinks
in
Advanced Prostate Cancer
5 months ago
Lutetium at earlier stage, clinical trial is enrolling
The second trial provides men with metastatic prostate cancer access to prostate-specific membrane antigen (PSMA)-targeted therapy prior to chemotherapy. Currently, PSMA-targeted therapy is only available after chemotherapy. However, phase III clinical trials have shown that PSMA-targeted therapies are
The second trial provides men with metastatic prostate cancer access to prostate-specific membrane antigen (PSMA)-targeted therapy prior to chemotherapy. Currently, PSMA-targeted therapy is only available after chemotherapy. However, phase III clinical trials have shown that PSMA-targeted therapies are
Maxone73
in
Advanced Prostate Cancer
5 months ago
Starting clinical trial of AVR-766
Today I start a clinical trial for ARV-766, an AR degrader. I'm coming in at phase 2, and they are only accepting men who have one of 4 point mutations in the AR - I have two. I've been randomized to 300 mg pill, once a day. The other dose is 100mg. I've failed ADT, chemo. Keytruda & Pluvicto. Hoping
Today I start a clinical trial for ARV-766, an AR degrader. I'm coming in at phase 2, and they are only accepting men who have one of 4 point mutations in the AR - I have two. I've been randomized to 300 mg pill, once a day. The other dose is 100mg. I've failed ADT, chemo. Keytruda & Pluvicto. Hoping
rsgdmd
in
Advanced Prostate Cancer
5 months ago
After Zytiga-Xtandi Fail!
Following up on a post by "Chris52981", after Zytiga and Xtandi fail, if chemo is the next treatment, how much time do we really buy? Is it Month's? Weeks? or Years?
Following up on a post by "Chris52981", after Zytiga and Xtandi fail, if chemo is the next treatment, how much time do we really buy? Is it Month's? Weeks? or Years?
TommyCarz2
in
Advanced Prostate Cancer
5 months ago
Recent HF diagnosis
Hi, I was diagnosed with heart failure a couple of months ago when I woke up one morning struggling for breath with fluid in my lungs, having had virtually no previous symptoms. Looking back, maybe I was a bit short of breath over the last few months but did a sprint-distance triathlon 6 months ago so
Hi, I was diagnosed with heart failure a couple of months ago when I woke up one morning struggling for breath with fluid in my lungs, having had virtually no previous symptoms. Looking back, maybe I was a bit short of breath over the last few months but did a sprint-distance triathlon 6 months ago so
izzibear
in
British Heart Foundation
5 months ago
PSA after chemo # 4
Hi My husbands last chemo was # 3 and PSA was 0.14, he just got the results from Chemo # 4 and it was at 0.12. This is the slowest decline if you look in the profile Iisted all his PSA results. Should we be worried that this last one barely moved ? Or is this slower decline good news? Thanks for any
Hi My husbands last chemo was # 3 and PSA was 0.14, he just got the results from Chemo # 4 and it was at 0.12. This is the slowest decline if you look in the profile Iisted all his PSA results. Should we be worried that this last one barely moved ? Or is this slower decline good news? Thanks for any
positive-thinking
in
Advanced Prostate Cancer
5 months ago
I need urgent help for my uncle.
My uncle who resides in France and is a holder of a French citizenship, has been diagnosed with terminal prostatic cancer. He had treated this condition in the past but it ultimately came back, but this time around doctors (including a specialist in Marseille) made him know that his condition was incurable
My uncle who resides in France and is a holder of a French citizenship, has been diagnosed with terminal prostatic cancer. He had treated this condition in the past but it ultimately came back, but this time around doctors (including a specialist in Marseille) made him know that his condition was incurable
Admhdu
in
Advanced Prostate Cancer
5 months ago
I need urgent help for my uncle
My uncle who resides in France and is a holder of a French citizenship, has been diagnosed with terminal prostatic cancer. He had treated this condition in the past but it ultimately came back, but this time around doctors (including a specialist in Marseille) made him know that his condition was incurable
My uncle who resides in France and is a holder of a French citizenship, has been diagnosed with terminal prostatic cancer. He had treated this condition in the past but it ultimately came back, but this time around doctors (including a specialist in Marseille) made him know that his condition was incurable
Admhdu
in
Advanced Prostate Cancer
5 months ago
chemo
has anyone who failed xtandi and zytiga have good outcome with chemo- does it completely eliminate the cancer or do you still have to take things after - how does it work when it stops - also can you take it in smaller doses?
has anyone who failed xtandi and zytiga have good outcome with chemo- does it completely eliminate the cancer or do you still have to take things after - how does it work when it stops - also can you take it in smaller doses?
Chris52981
in
Advanced Prostate Cancer
5 months ago
Treatment plan / second opinions
hi everyone! first time poster - probably won’t be my last !! Just at the start of this journey, mums getting her Treatment Plan for first line treatment on Friday and I’d love any thoughts on what questions we should be asking? And would this be the stage for getting a second opinion (and is it
hi everyone! first time poster - probably won’t be my last !! Just at the start of this journey, mums getting her Treatment Plan for first line treatment on Friday and I’d love any thoughts on what questions we should be asking? And would this be the stage for getting a second opinion (and is it
georgiageorgia182
in
My Ovacome
5 months ago
what have I joined?
I have a Brian tumour had the surgery now going to treatment radio chemo etc… Been told exercise is good Any advice on how much? Or little? any tips on best diets
I have a Brian tumour had the surgery now going to treatment radio chemo etc… Been told exercise is good Any advice on how much? Or little? any tips on best diets
Ppmoorman65
in
Glioblastoma Support
5 months ago
Rechallenge Docetaxel - more than 6?
My husband has just finished his rechallenge of Docetaxel on 2/29x He did 6 rounds and while things are shrinking it didn’t have the significant change I think they wanted. So his MO at Mayo now wants him to do more chemo until he can no longer tolerate. It’s the standard 75g and my wrestle is why
My husband has just finished his rechallenge of Docetaxel on 2/29x He did 6 rounds and while things are shrinking it didn’t have the significant change I think they wanted. So his MO at Mayo now wants him to do more chemo until he can no longer tolerate. It’s the standard 75g and my wrestle is why
mdiaz76
in
Advanced Prostate Cancer
5 months ago
Discoloured teeth
Has anyone had trouble with discolouration of their teeth? I have been cleaning regularly but was told to rinse with corsodyl which I think is the cause of the problem. Of course, I haven't been to a hygienist in ages as still having chemotherapy. I know this is a cosmetic thing but it is really getting
Has anyone had trouble with discolouration of their teeth? I have been cleaning regularly but was told to rinse with corsodyl which I think is the cause of the problem. Of course, I haven't been to a hygienist in ages as still having chemotherapy. I know this is a cosmetic thing but it is really getting
Swimbuddy
in
My Ovacome
5 months ago
Confused
UPDATE: April 5, 2024 Yesterday was very disappointing as my husbands PSA increased again by 183 points, last month his PSA was 1546 and now it is 1730. All his other CBC results were good. His Alkaline Phosphatase increased 6 points, last month 127 and now 133 but still in range of 40-150. Questioned
UPDATE: April 5, 2024 Yesterday was very disappointing as my husbands PSA increased again by 183 points, last month his PSA was 1546 and now it is 1730. All his other CBC results were good. His Alkaline Phosphatase increased 6 points, last month 127 and now 133 but still in range of 40-150. Questioned
MsHope
in
Advanced Prostate Cancer
5 months ago
CLL survival times ARE improving, thanks to BTK and BCL-2 inhibitors
Many of us were shocked after our CLL/SLL diagnosis when we googled for survival times. [u]Hopefully[/u] we subsequently read that search engine information from Google, Bing, etc., is way out of date, due to the fact that with CLL being a chronic disease, the relatively long survival times with this
Many of us were shocked after our CLL/SLL diagnosis when we googled for survival times. [u]Hopefully[/u] we subsequently read that search engine information from Google, Bing, etc., is way out of date, due to the fact that with CLL being a chronic disease, the relatively long survival times with this
AussieNeil
Partner
in
CLL Support
5 months ago
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