Experiences with

Gonadotrophin releasing hormone (GnRH)

Buserelin, Goserelin, Leuprorelin & Triptorelin are GnRH agonists, whereas Degarelix is a GnRH antagonist.

I had a GNRH injection in July and still haven’t had a period, is this normal? I did have my endometriosis surgery in late November, but expected my periods to be back by now?

I've just started GNRH agonist injections and my gyno has recommended that I see a dietician alongside treatment. Thanks for your help!

Hi all, I had a GNRH injection back in July and haven’t had a period since… is this normal? Feels like a very long time!

Just wondered if anyone had a period after having the GnRH injection? I had my first injection on 17th October, on 30th October I have started a heavy painful period.

Hi, I have been on prostrap and then zoladex for the past 2.5 years. This was to help with pain which it did initially and i have been waiting for so long for an op. One year ago my consultant said persevere bit longer. Its only licensed for a 6 months and I'm concerned that I'm doing more damage

We tested the nontoxic, readily available, inexpensive FWGE, together with the conventional treatment, GnRH analogue, in 36 CRPC patients.

Some surgeons like you to be on GnRH agonists (eg zoladex) to make surgery easier; others like to see inflammation and endo in all its glory. But there is no evidence either way so don't be pressured into having GnRH agonists prior to surgery against your will.

If bleeding continues after second dose of decapeptyl 3.75 mg injection is normal ?What is the cause of bleeding

The surgeon said this was quiet bad and wants to put me on GnRH injections. Now my symptoms aren’t too bad (I started the mini pill a few months ago) and I’m lucky that at the moment they are fairly manageable so I don’t feel like I need intervention for pain relief.

Also not sure of quality of eggs after being so long on GNRH injections if we want to do another ivf starting from scratch. If you had done egg retrieval after being on GNRH let me know. Appreciate if anyone having similar experiences to share here 😍

I then received a letter from my consultant a few months later to say that he recommended the total hysterectomy and that I start a course of GNRH injections once I have had an udated MRI.

I read a paper saying that GnRH agonists work better for endo if they are started in the luteal phase. I know that GnRH is a totally different substance to the combined pill, but it just made me wonder if there is any research or information about this for oestrogen and progesterone?

Long story short I was put on GNRH analogues and told that my only option was a hysterectomy. I moved to a BSGE hospital and got a second opinion. The care was much better. I finally had a cystoscopy and a laparoscopy. I feel validated with what has been found but also lost.

GnRH therapy to be discussed. I understand most of what it says but I don't know what the last bit is, the next step. Can anyone enlighten me?

I am in process of having treatment at a US clinic and they have advised to add in Buserelin known as Suprecur (GnRH analogue) into my treatment but it is out of stock in the UK. They have suggested several different other options which are either unavailable in the UK or out of stock.

I have the worst mood swings, I am currently on GnRh injections to stop my ovaries as the doctors have thought it is my periods causing my severe mood swings but I am still the same.

Sadly it looks like my cyst had leaked recently and there was a lot of endo in there (disseminated intraperitoneal superficial endometriosis according to my discharge letter), and they want to put me on GnRH medication to get it under control.

My consultant said my other 2 options are GNRH injections or surgery. I’m not keen on injections with them only being a short term fix but I’m worried about surgery. I’m just wondering what your experiences are and what you recommend/how are you managing endo?

Hi, been on gnrh injection for the past 4 months and for the past 2 months I’ve developed severe eczema and swelling on my eyelids. Did anybody else have a similar reaction? I’m trying to see if the two are linked