Experiences with

Gonadotrophin releasing hormone (GnRH)

My gynocologist has also said i may need to consider going on Gnrh analogue, which i really dont want to, due to all the horrible side effects .

Hi all , I have been on Decapeptyl injections now for 6 weeks alongside hrt ( everol 50 patches and Utrogestan 100mg continuously ) Iam currently having brown spotting and all my Endo symptoms again for the past 3 days Has anyone else had this ? Will it settle the longer iam on the injections ? Is

I have all the risk factors for OHSS, but we are mitigating as much as possible (gnrh agonist trigger, freezing eggs, Cabergoline, clexane and gnrh antagonist for the next few days). For those who have had OHSS, how long after the collection did you start to get symptoms?

Findings suggest that for 6-month ADT courses, maintaining castrate testosterone levels for 11 months optimizes MFS, offering valuable insights for clinical decision-making, particularly concerning newer GnRH antagonists that expedite TR.

On one side it seems that relugolix would decrease the risk of cardiovascular events (as all GnRH antagonists). I say it seems because it's not confirmed. Plus of course I can take it without having to have an injection.

Hormone treatment has been offered GnRH analogues, reading online it doesn't work for everyone and the side effects are wild, my main concern being mental health as I already struggle with that.

Two years in to my de novo high volume metastatic prostate cancer diagnosis, I am pleased to report excellent results so far with triplet therapy (Docetaxel chemo completed, Abiraterone ARPI, Firmagon/Degarelix GnRH antagonist as ADT). However I would be grateful for any advice today.

The fracture risk is directly correlated with the number of GnRH agonist doses given.

the surgeon told me post op that she couldn’t remove any endo and she suggested GNRH injections.

Hi ladies I am hopeless and devastated so down spirited I found many useful posts here thought I share my concerns with you if anyone have similar experiences to share I really appreciate although my case might be very rare due to having adenomyosis removed- normally its being treated only with GNRH

I then had the GnRH injection lasting 3 months… I’m awaiting my second surgery within this time 🤞 Taking tibolone to help with side affects. I no longer really know what’s good or bad care… What’s normal with this disease. From the pains in back to all the way down the legs.

Hi I decided to stop using GNRH analogues 11 months ago. I was on them for 2 years waiting surgery. Still waiting for surgery going into my 4th year. My periods have not returned anyone know if they will? I am 42?

I have been contemplating going privately or trying GnRh injections until I get a date. I can't have the contraceptive pill, ibuprofen or the coil. Has anyone got any advice on pain relief going forward until I can have this laprocospy again? Currently taking mefenamic acid. Thank you 🙂

And because of the pharmacokinetics of this excellent GnRH antagonist ADT drug, it's recommended that you take it every day at exactly the same time. And if you miss a dose apparently it's not a good thing.

What has anyone else’s experience been with GnRH?

As of December 2023, I have been put on GnRH (Triptorelin) with add back (Tibolone) and frankly I am wondering where this merry-go-round of feeling dreadful stops?! 🤯 My day-to-day quality of life is not good at all.

Also, may sound stupid but if you have the Mirena & GnRH + Tibolone - is there a possibility I could start bleeding again?

I sought help again and asked to be referred to an endo specialist centre - only to be seen 13 months later and not placed on the endometriosis clinic… I was told I had to try the coil initially and then look at Gnrh injections which I really don’t want to go down the route of having due to the side

I aldo started L arginin to help my lining grow bcuz it was very thin and not growing properly after stopping all gnrh and hormones despite my estrogen levels were good before going out of wack 3 weeks after last ovulation.

Just wondering when did your cycles return back to normal after stopping GNRH injections (zoladex etc)? I’m only a few days after the 28 days mark so not sure what to expect.