the TRANSPORT analysis of T recovery after ADT for localized PCa

[SierraSix]

Summary Paragraph:

The study examines testosterone recovery (TR) in prostate cancer patients undergoing androgen deprivation therapy (ADT) in conjunction with radiotherapy, as assessed across multiple randomized trials by the MARCAP Consortium. Variabilities in TR were identified based on ADT duration, baseline testosterone levels, and patient age. The study provided TR timelines towards noncastrate and nonhypogonadal levels, demonstrating a complex non-linear relationship between TR and metastasis-free survival (MFS). Findings suggest that for 6-month ADT courses, maintaining castrate testosterone levels for 11 months optimizes MFS, offering valuable insights for clinical decision-making, particularly concerning newer GnRH antagonists that expedite TR. The study also highlighted that prolonged effective castration periods might increase oncological benefits in some patient cohorts, though these observations warrant further research for confirmation.

sciencedirect.com/science/a...

[BubbaC]

Not sure if you have a specific question, but during the last nearly 3 years, have been treated with ERBT, brachytherapy and ADT (Orgovyx). I have been on ADT for over 30 months and plan to cease at year end, giving me close to 3 full years. Happy to respond to any questions.

[Laun]

I had radiation back in 1998. No adt with. Have some problem with coming back so use adt now and just added Nebuqa now since now castratesensitive