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How long to Castrate Resistance: ADT+/- ARSI
Further discussion on details of EMBARK study on another HU forum bears restating here (IMO). For high risk BCR (and beyond) ADT combined with ARSI (in this case enzalutamide) is clearly superior to either monotherapy. However, development of castrate resistance between ADT + Enza vs. Enz monotherapy
Further discussion on details of EMBARK study on another HU forum bears restating here (IMO). For high risk BCR (and beyond) ADT combined with ARSI (in this case enzalutamide) is clearly superior to either monotherapy. However, development of castrate resistance between ADT + Enza vs. Enz monotherapy
MateoBeach
in
Advanced Prostate Cancer
9 months ago
anyone on estradiol?
My gp want to prescribe me estradiol internal tablets.. ( just to confirm...the ones that go up there!. Not patches cream or by mouth ) I'm 11 years post menopause. I hardly ever have relationships or sex because it's just impossible or agony.. Have tried ' yes ' lubricant get in the past.. With
My gp want to prescribe me estradiol internal tablets.. ( just to confirm...the ones that go up there!. Not patches cream or by mouth ) I'm 11 years post menopause. I hardly ever have relationships or sex because it's just impossible or agony.. Have tried ' yes ' lubricant get in the past.. With
MrsClanger
in
Thyroid UK
11 months ago
Do low PSA-producing cells still rely on testosterone to grow?
Am curious to know what the folks here know about this question. If higher PSA cells are driven to near extinction by ADT, and if only low-PSA producing cells survive, are the latter still dependent on testosterone for survival? If not, what do they depend on to grow?
Am curious to know what the folks here know about this question. If higher PSA cells are driven to near extinction by ADT, and if only low-PSA producing cells survive, are the latter still dependent on testosterone for survival? If not, what do they depend on to grow?
novatimo
in
Advanced Prostate Cancer
9 months ago
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Hormone Replacement Therapy (HRT)
I just recently read some interesting studies that suggest HRT could help us PD people with our symptoms? I know for some HRT is controversial. And maybe I am at the point of desperation, but should I just be asking my GP for an HRT patch? Have any of you had any experience with HRT. Is one delivery
I just recently read some interesting studies that suggest HRT could help us PD people with our symptoms? I know for some HRT is controversial. And maybe I am at the point of desperation, but should I just be asking my GP for an HRT patch? Have any of you had any experience with HRT. Is one delivery
PalmSprings
in
Cure Parkinson's
9 months ago
Would I be on thin ice if I tried adaptive ADT this soon?
After 6 weeks on Lupron and 9 days on abiraterone, my PSA was .1, and my testosterone was <1. This is within the criteria being used to start people on adaptive in this MCSPC Moffitt study with Jingsong Yang - (he says I can just follow the protocol without being in the study)https://pubmed.ncbi.nlm.nih.gov
After 6 weeks on Lupron and 9 days on abiraterone, my PSA was .1, and my testosterone was <1. This is within the criteria being used to start people on adaptive in this MCSPC Moffitt study with Jingsong Yang - (he says I can just follow the protocol without being in the study)https://pubmed.ncbi.nlm.nih.gov
jackwfrench
in
Advanced Prostate Cancer
9 months ago
Reporting results from Eclipse Trial
Prior to beginning trial last June I had just gone castrate resistant and PSA was at 3.3. A few weeks after the last of four injections PSA settled in at .25 so there was still something left. However PSA now has quickly shot up to .75 And since I stopped Orgovyx and Zytiga, Testosterone is going up
Prior to beginning trial last June I had just gone castrate resistant and PSA was at 3.3. A few weeks after the last of four injections PSA settled in at .25 so there was still something left. However PSA now has quickly shot up to .75 And since I stopped Orgovyx and Zytiga, Testosterone is going up
SViking
in
Advanced Prostate Cancer
9 months ago
Yes, Yes, Yes, are you kidding. Sexual performance, primal male dominance, self confidence are all affected by pelvic radiation.
I had pelvic radiation daily for a month. By day 3 the lymph nodes were 60% reduced in size. Side note when the beam hits the outer layer of skin it actually spreads out in a V shape so precision is kinda lost. Within a few years maybe one year I felt less manly, couldn't perform in bed with my gorgeous
I had pelvic radiation daily for a month. By day 3 the lymph nodes were 60% reduced in size. Side note when the beam hits the outer layer of skin it actually spreads out in a V shape so precision is kinda lost. Within a few years maybe one year I felt less manly, couldn't perform in bed with my gorgeous
Shaunjon
in
Pelvic Radiation Disease Association
9 months ago
Low cortisol but within normal nhs range
I have had 2 blood cortisol tests at 9am 1st one was 133 nmol/L and the 2nd one was 233 nmol/L . I asked to have a short synacten test to see if my pituitary is failing ( hypopituitarism) , as one of my big symptoms is low motivation, tiredness, hypothyroidism and zero libido for years despite being
I have had 2 blood cortisol tests at 9am 1st one was 133 nmol/L and the 2nd one was 233 nmol/L . I asked to have a short synacten test to see if my pituitary is failing ( hypopituitarism) , as one of my big symptoms is low motivation, tiredness, hypothyroidism and zero libido for years despite being
minus
in
Thyroid UK
9 months ago
Can anyone shed light on my blood test results? Taking NDT. Thank you!
Hello all, Would someone be able to offer any insight to my blood tests results here at all? Many thanks. I take 310mg of Erfa NDT. I have hypothyroidism (hashi) and am a 46 year woman (so perimenopausal) and have two children. I exercise daily for at an hour. I have coeliac disease and am gluten free
Hello all, Would someone be able to offer any insight to my blood tests results here at all? Many thanks. I take 310mg of Erfa NDT. I have hypothyroidism (hashi) and am a 46 year woman (so perimenopausal) and have two children. I exercise daily for at an hour. I have coeliac disease and am gluten free
DaisyJones1
in
Thyroid UK
10 months ago
Help with test results and next step please…on NDT
Hello all, Would someone be able to offer any insight to my tests results here at all? Many thanks. I take 310mg of Erfa NDT. I have hypothyroidism (hashi) and am a 46 year old woman (so perimenopausal) and have two children. I exercise daily for at an hour. I have coeliac disease and am gluten free
Hello all, Would someone be able to offer any insight to my tests results here at all? Many thanks. I take 310mg of Erfa NDT. I have hypothyroidism (hashi) and am a 46 year old woman (so perimenopausal) and have two children. I exercise daily for at an hour. I have coeliac disease and am gluten free
DaisyJones1
in
Thyroid UK
10 months ago
Testosterone Vs. Testosterone Replacement Therapy
Need Feedback please RE: Natural Testosterone & TRT
Just spoke to my MO (a very well known Oncologist -here in LA) about my Testosterone.
Have been off Orgovyx now for 4 & half Months.
Latest Blood labs are Testosterone 79.
Oncologist says T probably will come back
Need Feedback please RE: Natural Testosterone & TRT
Just spoke to my MO (a very well known Oncologist -here in LA) about my Testosterone.
Have been off Orgovyx now for 4 & half Months.
Latest Blood labs are Testosterone 79.
Oncologist says T probably will come back
JWS13
in
Advanced Prostate Cancer
9 months ago
A List for Newly Diagnosed that My Wife did in 2022 please add to list if anything is missed or wrong or needs updating. TIA
I have to pack, moving trucks coming in AM…and Rest… She shared this on a farce book group page. This List Is Not Complete Please feel free to Message Chat Us with your Email as items on the listing example: ie: were deleted / removed by a healthunlocked admin. The original post keeps getting modified
I have to pack, moving trucks coming in AM…and Rest… She shared this on a farce book group page. This List Is Not Complete Please feel free to Message Chat Us with your Email as items on the listing example: ie: were deleted / removed by a healthunlocked admin. The original post keeps getting modified
Shorehousejam
in
Advanced Prostate Cancer
9 months ago
Conflicting MRI vs PSMA scans
Well it appears that the radiologist who did my MRI was overly cautious. The report said I had a met on my left pelvis, one on my right pelvis, one on my sacrum, additional cancer in my prostate region and sclerotic foci in my pelvic region. Traumatic. We followed that up with a PSMA scan 10 days
Well it appears that the radiologist who did my MRI was overly cautious. The report said I had a met on my left pelvis, one on my right pelvis, one on my sacrum, additional cancer in my prostate region and sclerotic foci in my pelvic region. Traumatic. We followed that up with a PSMA scan 10 days
icanwintwice
in
Advanced Prostate Cancer
9 months ago
Does testosterone fluctuate after ADT ends?
My treatment (Radiation/Lupron/Abirateron/Prednisone) ended on May 2. Gradually my testosterone began to come back. In August it was at 3 nmol/L and in Oct 6 it was 11 nmol/L so it is on a upward trend as can be expected. However I am wondering if there are up and down fluctuations because while
My treatment (Radiation/Lupron/Abirateron/Prednisone) ended on May 2. Gradually my testosterone began to come back. In August it was at 3 nmol/L and in Oct 6 it was 11 nmol/L so it is on a upward trend as can be expected. However I am wondering if there are up and down fluctuations because while
Mascouche
in
Advanced Prostate Cancer
10 months ago
Advice Please…
hi everyone, I just received a negative on my beta. This was my second FET transfer. I have a consult with the doctor on Monday and was wondering if there is anything else I could try and do if not doing already. A little history…. • Diagnosed with ENDOMETRIOSIS • Diagnosed with HYPOTHYROIDISM
hi everyone, I just received a negative on my beta. This was my second FET transfer. I have a consult with the doctor on Monday and was wondering if there is anything else I could try and do if not doing already. A little history…. • Diagnosed with ENDOMETRIOSIS • Diagnosed with HYPOTHYROIDISM
Vmi913
in
Fertility Network UK
11 months ago
Just joined the club no one wants to be a member of in April 2023 - can Gleason 9 be cured ?
Doc says that our goal is a cure despite the fact that I am a Gleason 9 with Decipher score of 1 , the highest for metatastic spread. (PSMA PET was negative.) The highest my PSA has ever been was 5.48 in December 2022 and it dropped to .09 with Testosterone of 14 in August two months after a shot of
Doc says that our goal is a cure despite the fact that I am a Gleason 9 with Decipher score of 1 , the highest for metatastic spread. (PSMA PET was negative.) The highest my PSA has ever been was 5.48 in December 2022 and it dropped to .09 with Testosterone of 14 in August two months after a shot of
68Guitar
in
Advanced Prostate Cancer
10 months ago
BAT trial
With Xtandi failing and my metastasizes not PSMA avid enough for Lutetium my MO referred me to the Kinghorn Cancer Centre in Sydney to be assessed for a clinical trial involving BAT and Carboplatin (chemo). I am now in the trial and have had my first testosterone injections plus the carboplatin infusion
With Xtandi failing and my metastasizes not PSMA avid enough for Lutetium my MO referred me to the Kinghorn Cancer Centre in Sydney to be assessed for a clinical trial involving BAT and Carboplatin (chemo). I am now in the trial and have had my first testosterone injections plus the carboplatin infusion
Bjry
in
Advanced Prostate Cancer
10 months ago
1st PSA Post SBRT + ADT: A Bounce?
I had a diagnosis of Gleason 3+4, probable ECE; Decipher .63. Received 5 Fraction SBRT at MSKCC (Dr. Zelefsky) in early January of this year. 6 months of ADT (Orgovyx) ended May 23, 2023. At the end of ADT, my PSA was <0.05 and Testosterone was 4. My first PSA Test was last Wednesday at Penn Medicine
I had a diagnosis of Gleason 3+4, probable ECE; Decipher .63. Received 5 Fraction SBRT at MSKCC (Dr. Zelefsky) in early January of this year. 6 months of ADT (Orgovyx) ended May 23, 2023. At the end of ADT, my PSA was <0.05 and Testosterone was 4. My first PSA Test was last Wednesday at Penn Medicine
Longrunner
in
Prostate Cancer Network
10 months ago
Latest results - fT3 overrange after commencing TRT
Hi, I posted the other day with an endo recomendation request and it was understandably closed for comments, but I'd appreciate any general comments on these results please. I'm a man. I started TRT (Testosterone Replacement Therapy) 4 months ago and just had follow up consultation after bloods this
Hi, I posted the other day with an endo recomendation request and it was understandably closed for comments, but I'd appreciate any general comments on these results please. I'm a man. I started TRT (Testosterone Replacement Therapy) 4 months ago and just had follow up consultation after bloods this
Decant
in
Thyroid UK
10 months ago
PCOS journey advice
I’m 28 and have been TTC for baby number 2 for 6 years. I was on Metformin for 4 years and the side effects were so brutal they advised me to stop. I’ve just had my second laparoscopy to remove a very large cyst which then gave me my first period after 2 years! My BMI is 34 which I am now trying so hard
I’m 28 and have been TTC for baby number 2 for 6 years. I was on Metformin for 4 years and the side effects were so brutal they advised me to stop. I’ve just had my second laparoscopy to remove a very large cyst which then gave me my first period after 2 years! My BMI is 34 which I am now trying so hard
Marinxoxo
in
Fertility Network UK
10 months ago
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