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Enzalutamide
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ED & zero libido
Instead of celebrating I am concerned that my treatment (Degaralix &
Enzalutamide
) might be loosing its effect. The past couple of oncology reviews have seen my PSA rising though the oncologist isn’t concerned. A bit of a quandary.
Instead of celebrating I am concerned that my treatment (Degaralix &
Enzalutamide
) might be loosing its effect. The past couple of oncology reviews have seen my PSA rising though the oncologist isn’t concerned. A bit of a quandary.
FortyWinks
in
Advanced Prostate Cancer
9 months ago
Efficacy and safety of BAT in CRPC following Abi or Enza resistance: A systematic review
"Bipolar androgen therapy (BAT) is a new endocrinologic treatment for castration-resistant prostate cancer (CRPC) that can restore some patients' sensitivity to drugs such as abiraterone (Abi) and
enzalutamide
(Enz). ...
"Bipolar androgen therapy (BAT) is a new endocrinologic treatment for castration-resistant prostate cancer (CRPC) that can restore some patients' sensitivity to drugs such as abiraterone (Abi) and
enzalutamide
(Enz). ...
pjoshea13
in
Fight Prostate Cancer
1 year ago
Are you on Xtandi (Enzalutamide), and reported the side effects of low sodium?
MO, Primary care, and other nurses are working hard to rollout why my sodium level is low (128) last. My first guess was lactulose. I stopped for one week and will recheck the level and schedule another appointment. Also, a Google search found many users reported that heavy use of lactulose
MO, Primary care, and other nurses are working hard to rollout why my sodium level is low (128) last. My first guess was lactulose. I stopped for one week and will recheck the level and schedule another appointment. Also, a Google search found many users reported that heavy use of lactulose
God_Loves_Me
in
Advanced Prostate Cancer
4 months ago
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A survey of open questions in adaptive therapy: Bridging mathematics and clinical translation, eLife, Review Article, Mar 23, 2023
Continuous Abiraterone or
eNZalutamide
in mCRPC (ANZadapt)[/i] [i]
https://www.clinicaltrials.gov/ct2/show/NCT05393791
[/i] BTW, the eLife Magazine website is a very rich resource for research of all types.
Continuous Abiraterone or
eNZalutamide
in mCRPC (ANZadapt)[/i] [i]
https://www.clinicaltrials.gov/ct2/show/NCT05393791
[/i] BTW, the eLife Magazine website is a very rich resource for research of all types.
cujoe
in
Fight Prostate Cancer
1 year ago
Latest from PubMed
Comparison of Cerebral Blood Flow in Regions Relevant to Cognition After
Enzalutamide
, Darolutamide, and Placebo in Healthy Volunteers: A Randomized Crossover Trial. Williams SCR, Mazibuko N, O'Daly O, Zurth C, Patrick F, Kappeler C, Kuss I, Cole PE.
Comparison of Cerebral Blood Flow in Regions Relevant to Cognition After
Enzalutamide
, Darolutamide, and Placebo in Healthy Volunteers: A Randomized Crossover Trial. Williams SCR, Mazibuko N, O'Daly O, Zurth C, Patrick F, Kappeler C, Kuss I, Cole PE.
Magnus1964
in
Advanced Prostate Cancer
1 year ago
Determinants of PSA Response to Bipolar Androgen Therapy [BAT]
Responders were more likely to have had a radical prostatectomy as definitive therapy and were more likely to have been treated with an androgen receptor (AR) antagonist (
enzalutamide
or apalutamide) immediately prior to BAT (compared to abiraterone).
Responders were more likely to have had a radical prostatectomy as definitive therapy and were more likely to have been treated with an androgen receptor (AR) antagonist (
enzalutamide
or apalutamide) immediately prior to BAT (compared to abiraterone).
pjoshea13
in
Fight Prostate Cancer
1 year ago
BAT in Argentina
Interestingly, the PSA-PFS for
enzalutamide
increased from 3.8 months after abiraterone to 10.9 months after BAT, and PFS2 with BAT followed by
enzalutamide
was significantly longer than with
enzalutamide
followed by BAT, proving the hypothesis that BAT can re-sensitise CRPC to subsequent antiandrogen
Interestingly, the PSA-PFS for
enzalutamide
increased from 3.8 months after abiraterone to 10.9 months after BAT, and PFS2 with BAT followed by
enzalutamide
was significantly longer than with
enzalutamide
followed by BAT, proving the hypothesis that BAT can re-sensitise CRPC to subsequent antiandrogen
pjoshea13
in
Fight Prostate Cancer
1 year ago
Triplet Regimen vs Clinical Trial (Pluvicto)
I was given information on apalutamide, darolutamide,
enzalutamide
, and abiraterone acetate. I’m not sure if I will have a choice, but I’d love to know if anyone has experience or opinions, especially if your disease has manifested similarly to mine.
I was given information on apalutamide, darolutamide,
enzalutamide
, and abiraterone acetate. I’m not sure if I will have a choice, but I’d love to know if anyone has experience or opinions, especially if your disease has manifested similarly to mine.
Bruce98
in
Advanced Prostate Cancer
1 year ago
XTANDI(Enzalutamide) Granted European Commission Approval for Use in Additional Recurrent Early Prostate Cancer Treatment Setting
...well...the title speaks for itself XTANDI is now the first and only novel hormone therapy available for the treatment of high-risk biochemical recurrent non-metastatic hormone-sensitive prostate cancer in the European Union (EU) XTANDI can be given alone or in combination with androgen deprivation
...well...the title speaks for itself XTANDI is now the first and only novel hormone therapy available for the treatment of high-risk biochemical recurrent non-metastatic hormone-sensitive prostate cancer in the European Union (EU) XTANDI can be given alone or in combination with androgen deprivation
Maxone73
in
Advanced Prostate Cancer
3 months ago
Abiraterone/enzalutamide+PARP inhibitor better than abiraterone/enzalutamide alone for mCRPC, even without BRCA+
By combining the PARP inhibitor (Lynparza (olaparib) or Talzenna (talazoparib)) with either abiraterone or
enzalutamide
, cancer progression was slowed, even in men who were BRCA-.
By combining the PARP inhibitor (Lynparza (olaparib) or Talzenna (talazoparib)) with either abiraterone or
enzalutamide
, cancer progression was slowed, even in men who were BRCA-.
Tall_Allen
in
Advanced Prostate Cancer
1 year ago
Small molecule ACK1 inhibitor (R)-9b - third generation AR receptor - clinical trial I in 2023
We have identified (R)-9b as a `third generation' of AR-antagonist, which has ability to overcome
Enzalutamide
and abiraterone-resistant prostate cancer.
We have identified (R)-9b as a `third generation' of AR-antagonist, which has ability to overcome
Enzalutamide
and abiraterone-resistant prostate cancer.
Hidden
in
Advanced Prostate Cancer
1 year ago
Certain Toxic Effects Higher With Newer PCa Therapies— Reviews suggests increased risks of cognitive adverse events, fatigue, falls
[/i] [i]Currently, there are four second-generation AAs approved by the FDA for metastatic hormone-sensitive prostate cancer: abiraterone (Zytiga),
enzalutamide
(Xtandi), apalutamide (Erleada), and darolutamide (Nubeqa).
[/i] [i]Currently, there are four second-generation AAs approved by the FDA for metastatic hormone-sensitive prostate cancer: abiraterone (Zytiga),
enzalutamide
(Xtandi), apalutamide (Erleada), and darolutamide (Nubeqa).
cujoe
in
Fight Prostate Cancer
1 year ago
Proteolysis Targeting Chimeras
"[i]The compounds ... significantly inhibit
enzalutamide
-resistant growth of castration resistant prostate cancer (CRPC) cells.
"[i]The compounds ... significantly inhibit
enzalutamide
-resistant growth of castration resistant prostate cancer (CRPC) cells.
pjoshea13
in
Fight Prostate Cancer
1 year ago
looking for recommendations,other options, last advice we got from a doc...nubeqa isn't working but let's keep doing it
-rising PSA and declining urinary function 1/2021,
enzalutamide
instituted with excellent initial PSA response but cognitive decline necessitating 50% dose reduction. PSA rising late 2021.
-rising PSA and declining urinary function 1/2021,
enzalutamide
instituted with excellent initial PSA response but cognitive decline necessitating 50% dose reduction. PSA rising late 2021.
Spring15-3
in
Prostate Cancer Network
1 year ago
Re engagement of Enzalutamide in the UK?
Ahead of an oncology appointment, I was wondering if anyone had had positive experience of this, especially in the UK? I have a feeling it is rarely entertained. There is little doubt this drug made the most difference in regressing my cancer but I was taken off it when my PSA started to rise. Despite
Ahead of an oncology appointment, I was wondering if anyone had had positive experience of this, especially in the UK? I have a feeling it is rarely entertained. There is little doubt this drug made the most difference in regressing my cancer but I was taken off it when my PSA started to rise. Despite
Finlay66
in
Advanced Prostate Cancer
1 year ago
Enzalutamide induced non-ischemic cardiomyopathy. Case report & review of literature on anti-androgen therapy-related cardiovascular events
This is a one-off case, but I wanted to share, just to help those of you on
Enzalutamide
, to be aware that this is possible: https://cardiooncologyjournal.biomedcentral.com/articles/10.1186/s40959-023-00160-7
This is a one-off case, but I wanted to share, just to help those of you on
Enzalutamide
, to be aware that this is possible: https://cardiooncologyjournal.biomedcentral.com/articles/10.1186/s40959-023-00160-7
GeorgeGlass
in
Advanced Prostate Cancer
1 year ago
Is Simvastatin more effective than the other statins, against PCa?
In castration-resistant LNCaPabl cells,
enzalutamide
combined with atorvastatin resulted in the most prominent growth inhibition. Notably, simvastatin and also rosuvastatin were able to increase the effect of
enzalutamide
in 22Rv1 cells.
In castration-resistant LNCaPabl cells,
enzalutamide
combined with atorvastatin resulted in the most prominent growth inhibition. Notably, simvastatin and also rosuvastatin were able to increase the effect of
enzalutamide
in 22Rv1 cells.
GeorgeGlass
in
Advanced Prostate Cancer
1 year ago
ASCO 23 - Transdermal square-wave testosterone therapy
Upon disease progression, therapy was switched to
Enzalutamide
(Enza) until progression. (This could be repeated again within the 12 month study period.) As with BAT, the men had CRPC & on ADT throughout. For results, see: https://meetings.asco.org/abstracts-presentations/217181
Upon disease progression, therapy was switched to
Enzalutamide
(Enza) until progression. (This could be repeated again within the 12 month study period.) As with BAT, the men had CRPC & on ADT throughout. For results, see: https://meetings.asco.org/abstracts-presentations/217181
pjoshea13
in
Fight Prostate Cancer
1 year ago
Interesting paper summarising state of art (2022) for ADT
From Chapter 7 “All four agents (docetaxel, abiraterone,
enzalutamide
, and apalutamide) have been FDA-approved for the treatment of metastatic, castration-sensitive prostate cancer and are now listed as category 1 recommendations within the NCCN guidelines.81 Treatment choice between agents for metastatic
From Chapter 7 “All four agents (docetaxel, abiraterone,
enzalutamide
, and apalutamide) have been FDA-approved for the treatment of metastatic, castration-sensitive prostate cancer and are now listed as category 1 recommendations within the NCCN guidelines.81 Treatment choice between agents for metastatic
Graham49
in
Advanced Prostate Cancer
1 year ago
Side effects of Enzalutamide: High blood pressure, Tinnitus & Headaches.
Side effects of
Enzalutamide
: High blood pressure, Tinnitus & Headaches. I have Advance Prostate Cancer Stage 4 with Metastasis to the lymph nodes and bones. Have been on Enza for approx 3 months. I am 66 yrs and living in Malaysia with my wife for the past 25 years.
Side effects of
Enzalutamide
: High blood pressure, Tinnitus & Headaches. I have Advance Prostate Cancer Stage 4 with Metastasis to the lymph nodes and bones. Have been on Enza for approx 3 months. I am 66 yrs and living in Malaysia with my wife for the past 25 years.
barry0405
in
Advanced Prostate Cancer
1 year ago
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