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Enzalutamide
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New 2024 AUA/ASTRO/SUO Guidelines for Salvage Therapy
https://www.prostatecancer.news/2023/05/xtandi-
enzalutamide
-adt-slows.html https://www.prostatecancer.news/2022/09/short-term-androgen-annihilation-in-non.html
https://www.prostatecancer.news/2023/05/xtandi-
enzalutamide
-adt-slows.html https://www.prostatecancer.news/2022/09/short-term-androgen-annihilation-in-non.html
Tall_Allen
in
Advanced Prostate Cancer
5 months ago
Treatment Question
She did say she was going to switch him from apalutamide to
enzalutamide
but that is due to a rash he has had from the apalutamide that is not going away. Thanks for your input.
She did say she was going to switch him from apalutamide to
enzalutamide
but that is due to a rash he has had from the apalutamide that is not going away. Thanks for your input.
Juju0713
in
Advanced Prostate Cancer
1 year ago
Senescent neutrophils and their subsequent impact on tumor progression and therapy resistance
So the next step is . . . to understand whether we can really run a new clinical trial to decide whether romidepsin can be used in combination with
enzalutamide
.
So the next step is . . . to understand whether we can really run a new clinical trial to decide whether romidepsin can be used in combination with
enzalutamide
.
cigafred
in
Fight Prostate Cancer
1 year ago
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BAT therapy - NIH article
Efficacy and safety of bipolar androgen therapy in castration-resistant prostate cancer following abiraterone or
enzalutamide
resistance: A systematic review. You X, Huang S, Wang X, Yi C, Gong N, Yu J, Xu C, Xiang Z.
Efficacy and safety of bipolar androgen therapy in castration-resistant prostate cancer following abiraterone or
enzalutamide
resistance: A systematic review. You X, Huang S, Wang X, Yi C, Gong N, Yu J, Xu C, Xiang Z.
Magnus1964
in
Advanced Prostate Cancer
1 year ago
ART Intermittent HT, Quality of Life, and Testosterone Recovery
Using Abiraterone,
Enzalutamide
with Prednisone along with ADT in the STAMPEDE Trial. MIN 23:02 – Bone Density. Loss bone mass a known side effect of ADT. Aledronate 70 mg/week showed spine, femoral and hip increases in bone mass density (BMD). https://youtu.be/_et0sSGLNTA?
Using Abiraterone,
Enzalutamide
with Prednisone along with ADT in the STAMPEDE Trial. MIN 23:02 – Bone Density. Loss bone mass a known side effect of ADT. Aledronate 70 mg/week showed spine, femoral and hip increases in bone mass density (BMD). https://youtu.be/_et0sSGLNTA?
RMontana
in
Active Surveillance - Prostate Cancer
10 months ago
A List for Newly Diagnosed that My Wife did in 2022 please add to list if anything is missed or wrong or needs updating. TIA
- These include: * ADT, Androgen Deprivation Therapy, which works by decreasing testosterone levels and slowing cancer growth * Hormonal therapies such as abiraterone and
enzalutamide
* Chemotherapy, such as Docetaxel Infusion Chemotherapy is often used after the body stops responding to hormone
- These include: * ADT, Androgen Deprivation Therapy, which works by decreasing testosterone levels and slowing cancer growth * Hormonal therapies such as abiraterone and
enzalutamide
* Chemotherapy, such as Docetaxel Infusion Chemotherapy is often used after the body stops responding to hormone
Shorehousejam
in
Advanced Prostate Cancer
9 months ago
Eliquis and Xtandi - Drug Interaction
also suggest
enzalutamide
may inhibit P-gp, though in vivo studies have yet to corroborate this finding.
also suggest
enzalutamide
may inhibit P-gp, though in vivo studies have yet to corroborate this finding.
Hawk56
in
Advanced Prostate Cancer
1 year ago
Updated treatment plan for progressing MCRPC
My Question is, should I switch the abiraterone for
enzalutamide
. There is some evidence for switching these drugs if one is no longer working. Apparently the dexamethasone is not good for bone health. Xgeva every 3 months, Xofigo every month for 6 months and possibly add
enzalutamide
.
My Question is, should I switch the abiraterone for
enzalutamide
. There is some evidence for switching these drugs if one is no longer working. Apparently the dexamethasone is not good for bone health. Xgeva every 3 months, Xofigo every month for 6 months and possibly add
enzalutamide
.
Islandboy2021
in
Advanced Prostate Cancer
1 year ago
Aplautamide, enzalutamide: low dose opinions
Hi Officially mcrpc. Can't get darolutamide so faced with choice of zytiga, xtandi or aplautamide in the coming weeks. Faced with the first two I would have opted for xtandi and hopefully worked towards taking two tablets. Maybe one but have seen a few progress at one and wonder if two would be an
Hi Officially mcrpc. Can't get darolutamide so faced with choice of zytiga, xtandi or aplautamide in the coming weeks. Faced with the first two I would have opted for xtandi and hopefully worked towards taking two tablets. Maybe one but have seen a few progress at one and wonder if two would be an
Rickytarr
in
Fight Prostate Cancer
1 year ago
Xtandi (enzalutamide) from India
Has anyone ordered
enzalutamide
from India? If so were there any problems, and what pharmacy did you use? There seems to be a plethora of them.
Has anyone ordered
enzalutamide
from India? If so were there any problems, and what pharmacy did you use? There seems to be a plethora of them.
Guber
in
Advanced Prostate Cancer
1 year ago
Update after consultation w/Royal Marsden
The trigger was a marginally raised PSA (now 4.4) and some evidence on more bone mets, failing
Enzalutamide
and being offered a course of chemo (which I declined) I want to stress that I've had the same onco for 14 yrs, and have huge respect for him.
The trigger was a marginally raised PSA (now 4.4) and some evidence on more bone mets, failing
Enzalutamide
and being offered a course of chemo (which I declined) I want to stress that I've had the same onco for 14 yrs, and have huge respect for him.
CrocodileShoes
in
Advanced Prostate Cancer
1 year ago
Enzalutamide/Xtandi monotherapy as ADT with fewer side effects than Lupron
Enzalutamide
monotherapy could probably be used instead of Lupron after radiation too.
Enzalutamide
monotherapy could probably be used instead of Lupron after radiation too.
GP24
in
Advanced Prostate Cancer
1 year ago
Survival outcomes and prognostic factors for first-line abiraterone acetate or enzalutamide in patients with metastatic CRPC
Patients with mCRPC who received first-line ARATs had better survival if they had a PSA nadir≦2 ng/mL or a TTN≧7 months. Further study is needed to determine if an early switch in therapy for those in whom neither is achieved may impact OS. https://bmccancer.biomedcentral.com/articles/10.1186/s12885
Patients with mCRPC who received first-line ARATs had better survival if they had a PSA nadir≦2 ng/mL or a TTN≧7 months. Further study is needed to determine if an early switch in therapy for those in whom neither is achieved may impact OS. https://bmccancer.biomedcentral.com/articles/10.1186/s12885
Seasid
in
Advanced Prostate Cancer
1 year ago
Casodex after castration resistance?
Wouldn't it negatively affect the effectiveness of
Enzalutamide
when/if my dad will have to use it in future considering they act using similar mechanisms? 2) Are those fluctuations in the level of testosterone normal for someone being on Zoladex for several years?
Wouldn't it negatively affect the effectiveness of
Enzalutamide
when/if my dad will have to use it in future considering they act using similar mechanisms? 2) Are those fluctuations in the level of testosterone normal for someone being on Zoladex for several years?
Nestorian
in
Advanced Prostate Cancer
1 year ago
Supraphysiological Androgens [SPA] Promote Tumor Suppressive Activity of the AR Through cMYC Repression and Recruitment of the DREAM Complex
Thus, we tested sequential treatment of prostate cancer models with SPA followed by the AR inhibitor
enzalutamide
. Our results indicate that acquired resistance to SPA can be overcome by treatment with
enzalutamide
, which induced upregulation of AR and increased susceptibility to SPA.”
Thus, we tested sequential treatment of prostate cancer models with SPA followed by the AR inhibitor
enzalutamide
. Our results indicate that acquired resistance to SPA can be overcome by treatment with
enzalutamide
, which induced upregulation of AR and increased susceptibility to SPA.”
pca2004
in
Fight Prostate Cancer
1 year ago
The CRP:Albumin ratio & CRPC Survival
Dividing the sample according to the first line treatment chosen, we found OS of 26.25 vs 5.9 months (p < 0.05), 27.71 vs 22.57 months (p < 0.05) and 27.36 vs 23.75 months (p = 0.12), for docetaxel, abiraterone and
enzalutamide
, respectively.
Dividing the sample according to the first line treatment chosen, we found OS of 26.25 vs 5.9 months (p < 0.05), 27.71 vs 22.57 months (p < 0.05) and 27.36 vs 23.75 months (p = 0.12), for docetaxel, abiraterone and
enzalutamide
, respectively.
pca2004
in
Fight Prostate Cancer
1 year ago
News from ESMO 2023, let’s hope all good!
https://www.urotoday.com/conference-highlights/esmo-2023/esmo-2023-prostate-cancer/147459-esmo-2023-enza-p-anzup-1901-
enzalutamide
-and-177lu-psma-617-in-poor-risk-metastatic-castration-resistant-prostate-cancer-mcrpc-a-randomized-phase-2-trial.html https://www.urotoday.com/conference-highlights/esmo
https://www.urotoday.com/conference-highlights/esmo-2023/esmo-2023-prostate-cancer/147459-esmo-2023-enza-p-anzup-1901-
enzalutamide
-and-177lu-psma-617-in-poor-risk-metastatic-castration-resistant-prostate-cancer-mcrpc-a-randomized-phase-2-trial.html https://www.urotoday.com/conference-highlights/esmo
Maxone73
in
Advanced Prostate Cancer
9 months ago
Any experience with fever please?
Treatments have been RPT in 15, 1st line ADT, RT to prostatic bed in 19,
enzalutamide
, 6 cycles Docetaxel ending Jan 23, Olaparib until April, currently on Aberaterone. PSA jumped from 2.8 July 22 to 729 March 23. It seems Chemo and Olaparib weren’t effective.
Treatments have been RPT in 15, 1st line ADT, RT to prostatic bed in 19,
enzalutamide
, 6 cycles Docetaxel ending Jan 23, Olaparib until April, currently on Aberaterone. PSA jumped from 2.8 July 22 to 729 March 23. It seems Chemo and Olaparib weren’t effective.
Cdel
in
Advanced Prostate Cancer
1 year ago
Enzalutamide at half strength?
I have high volume mrpca and have had triplit therapy with
enzalutamide
at 160 mg per day. My response has been great with PCA falling from 700 at diagnosis to undetectable at 3 measurements over the last 6 months.
I have high volume mrpca and have had triplit therapy with
enzalutamide
at 160 mg per day. My response has been great with PCA falling from 700 at diagnosis to undetectable at 3 measurements over the last 6 months.
Jim53
in
Advanced Prostate Cancer
1 year ago
Enzalutamide or Darolutamide
Hi, I have advanced metastatic hormone sensitive prostate cancer and as well as my usual three monthly ADT (Lucrin-Depot) injection, I have been offered either
Enzalutamide
(Xtandi) or Darolutamide (Nubeqa). My PSA is currently below 0.1 due to the Lucrin-Depot.
Hi, I have advanced metastatic hormone sensitive prostate cancer and as well as my usual three monthly ADT (Lucrin-Depot) injection, I have been offered either
Enzalutamide
(Xtandi) or Darolutamide (Nubeqa). My PSA is currently below 0.1 due to the Lucrin-Depot.
x-rays1
in
Advanced Prostate Cancer
1 year ago
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