Efficacy and safety of BAT in CRPC following Abi or Enza resistance: A systematic review

[pjoshea13]

New meta-analysis below [1] [2].

Hard to believe that there are enough BAT studies to perform this particular meta-analysis (i.e. post-Abi/Enza).

Now we need to have studies of BAT (or LongBAT) to prevent CRPC.

"Bipolar androgen therapy (BAT) is a new endocrinologic treatment for castration-resistant prostate cancer (CRPC) that can restore some patients' sensitivity to drugs such as abiraterone (Abi) and enzalutamide (Enz). ...

"In a total of 108 unique records, ten studies were included in the final meta-analysis.

"Participants who underwent BAT achieved a PSA50 response rate of 27% ...

"Patients who completed BAT proceeded to AR-targeted therapy (Abi or Enz) and achieved a PSA50 response rate of 57% ...

"Patients with prior Enz resistance had a stronger impact on the PSA50 of AR-target therapy rechallenge.

"The results of this meta-analysis indicate that BAT is a safe and effective treatment for patients who have progressed after Abi or Enz. BAT can trigger the resensitization of patients with CRPC to subsequent endocrine therapy and improve the overall survival of patients and their quality of life." ...

-Patrick

[1] Full Text: readcube.com/articles/10.33...

[2] Abstract: pubmed.ncbi.nlm.nih.gov/371...

[cujoe]

Patrick,

Many thanks for restoring some content to the BAT story that others once provided almost daily here. As a true pioneer in BAT (using your personal n=1 methodology) even before it was called BAT, your perspective is especially valuable to the rest of us PCa patients.

Your statement "Now we need to have studies of BAT (or LongBAT) to prevent CRPC" is spot-on and reflects the fact that, as with PSMA-directed therapies, it seems logical that earlier use of such treatment (when the cancer population is less diversified) should produce superior results across the board.

Maybe meta-studies like this will help move BAT down to the HS population who, as yet, only have official access via CTs.

Hope all is well with you and yours, Ciao - Kaptin K9

[KocoPr in reply to cujoe]

How do we get the rigidity out of clinical trials? I understand the reasoning behind strict adherence. We need to be able to be flexible with when to go off the hight T cycle per individual’s PSA level.

Maybe Artificial Intelligence is the key. (scout4answers) recent post.

[pca2004 in reply to cujoe]

Hi Cujoe,

Was wondering why I wasn't being notified of replies & eventually realized they were going to the email address that I am locked out of. So I tried to change that address to my new address & was told that the address was already being used ... just can't win.

Noticed that Magnus posted the study elsewhere. Hasn't been shot down (yet).

Responses include a good testamonial from mtnwife.

Best, -Patrick (aka pjoshea13)

[cujoe in reply to pca2004]

Patrick O'Shea, the man with multiple IDs that he can't use. Someday that may well be to your advantage. Eons ago I got locked out of my AOL account (remember them?) and was being charged for sevices not being used. As with many ISP/email services, they didn't list a physical address or a phone number to contact or call when you have a problem. I eventually was able to find a phone number and call and get the service terminated and my unused charges credited. (As I remember it, I had to list which ancestors fought in the Revolutionary War to be verified I was the owner of the account.)

Not sure if anything like that would work for you to possibly merge the two email addresses into one account. I have two email addresses assigned to my one Yahoo account and both show up in the daily email chain.

Maybe Chat GPT can bail you out with a solution? Good Luck. (And as j-o-h-n likes to add, Good Health!).

Paz - Kaptin K9

[NPfisherman]

Patrick,

The data has shown the utility of BAT in MCRPC... resensitization to AR drugs... PSA50 drop for some, etc....

Will we see someone like Denmeade or Sartor push it to the MHSPC state in a trial?? I believe so ... These things trend that way... the AR drugs did ....abi, enza, etc... The treatment paradigm is evolving so rapidly...

Thanks for posting..

Don Pescado

[KocoPr in reply to NPfisherman]

they just cant be rigid with their cycles.

[NPfisherman in reply to KocoPr]

You mentioned up above your concerns on the need to be flexible on when to drop off high T levels related to PSA. BAT is advancing so rapidly in related to things like androgen cycling and tweaking BAT. There are a number of n=1 stories of success and ongoing adjustments here... It is why I will likely put up a post soon. It is time...

Thanks KocoPr...

[Ramp7]

I am in my 3rd cycle of BAT. Propionate. My PSA has gone down more than 50%.

[NPfisherman in reply to Ramp7]

Fantastic ... glad this has worked so well for you... This is the forum for BAT and a number of n=1 experiments are ongoing... Do you brethern of the BAT have an ongoing chat?? ...Maybe you should...

Don Pescado

[Ramp7 in reply to NPfisherman]

All my information is on a pdf. It is regularly shared with Denmeade, Beltran, my local MO, and my Urologist. Contact me, I shall share to date my progress.

[NPfisherman in reply to Ramp7]

Thanks for your offer, Ramp7.... You guys are gonna make me write a post... I can feel it in me bones...

The Old Don