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Genetics - Some answers but not all
TP53 outperforms other androgen receptor biomarkers to predict abiraterone or
enzalutamide
outcome in metastatic castration-resistant prostate cancer. Clin Cancer Res. 2019;25(6):1766–73. https://doi.org/10.1158/1078-0432.CCR-18-1943.
TP53 outperforms other androgen receptor biomarkers to predict abiraterone or
enzalutamide
outcome in metastatic castration-resistant prostate cancer. Clin Cancer Res. 2019;25(6):1766–73. https://doi.org/10.1158/1078-0432.CCR-18-1943.
spw1
in
Advanced Prostate Cancer
1 year ago
Why we add an AART drug to ADT?
So
enzalutamide
or apalutamide used without ADT will increase circulating T while simultaneously blocking it at the AR receptors. This may not apply to darolutamide which does not cross into the brain to reach the hypothalamus.
So
enzalutamide
or apalutamide used without ADT will increase circulating T while simultaneously blocking it at the AR receptors. This may not apply to darolutamide which does not cross into the brain to reach the hypothalamus.
MateoBeach
in
Fight Prostate Cancer
1 year ago
I've Prostate Cancer Stage 4 Mets to lymph nodes & bones. On Hormonal Trmt Enzalutamide. Has anyone undergo Prostactomy Da Vinci Surgery?
On Hormonal Trmt
Enzalutamide
. Has anyone undergo Prostactomy Da Vinci Surgery?
On Hormonal Trmt
Enzalutamide
. Has anyone undergo Prostactomy Da Vinci Surgery?
barry0405
in
Advanced Prostate Cancer
2 years ago
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I've Prostate Cancer Stage 4 Mets to lymph nodes & bones. On Hormonal Trmt Enzalutamide. Has anyone undergo Prostactomy Da Vinci Surgery?
On Hormonal Trmt
Enzalutamide
. Has anyone undergo Prostactomy Da Vinci Surgery?
On Hormonal Trmt
Enzalutamide
. Has anyone undergo Prostactomy Da Vinci Surgery?
barry0405
in
Advanced Prostate Cancer
2 years ago
I've Prostate Cancer Stage 4 Mets to lymph nodes & bones. On Hormonal Trmt Enzalutamide. Has anyone undergo Prostactomy Da Vinci Surgery?
On Hormonal Trmt
Enzalutamide
. Has anyone undergo Prostactomy Da Vinci Surgery?
On Hormonal Trmt
Enzalutamide
. Has anyone undergo Prostactomy Da Vinci Surgery?
barry0405
in
Advanced Prostate Cancer
2 years ago
Is Radium223 treatment suitable option for me now
Some participants will get course of Radium223 others will get course of
Enzalutamide
. Just found out I have been assigned to the Radium223 group I have some bone mets (pelvic and L3 area) but no bone pain.
Some participants will get course of Radium223 others will get course of
Enzalutamide
. Just found out I have been assigned to the Radium223 group I have some bone mets (pelvic and L3 area) but no bone pain.
Ronnie7C
in
Advanced Prostate Cancer
1 year ago
Enzalutamide (Xtandi) or not
several in left back lymph nodes. 2020 Rising PSA to 11.8 with 2 mets to spine and one in Ribs plus several in left back lymph nodes 2021 (March) went on 3 monthly shots ADT (Lucrin Depot) since March last year PSA has been undetectable for the past year. 2022 My MO has asked if I would like to go on
Enzalutamide
several in left back lymph nodes. 2020 Rising PSA to 11.8 with 2 mets to spine and one in Ribs plus several in left back lymph nodes 2021 (March) went on 3 monthly shots ADT (Lucrin Depot) since March last year PSA has been undetectable for the past year. 2022 My MO has asked if I would like to go on
Enzalutamide
x-rays1
in
Advanced Prostate Cancer
2 years ago
Enzalutamide side effects
On Hormonal Trmt
Enzalutamide
. Headaches and immense fatigue.Does anyone have a good coping mechanism ? Medication or supplements? How long will the side effects last ?
On Hormonal Trmt
Enzalutamide
. Headaches and immense fatigue.Does anyone have a good coping mechanism ? Medication or supplements? How long will the side effects last ?
barry0405
in
Advanced Prostate Cancer
2 years ago
Cabazitaxel for dad
He had
enzalutamide
but this stopped working too. It just seems like nothing is working I feel so low and for him. Guess I’m looking for some hope as to whether Cabazitaxel can turn things around? He’s never really any kind of remission - is this unlikely now?
He had
enzalutamide
but this stopped working too. It just seems like nothing is working I feel so low and for him. Guess I’m looking for some hope as to whether Cabazitaxel can turn things around? He’s never really any kind of remission - is this unlikely now?
SC19
in
Advanced Prostate Cancer
1 year ago
In hospital with neutropenia following 1st cycle of Docetaxel. Considering discontinuing Docetaxel, is that reasonable?
Should I just stay on ADT and
Enzalutamide
?
Should I just stay on ADT and
Enzalutamide
?
Jay-kud8
in
Advanced Prostate Cancer
1 year ago
FYI: New data on progression of visceral mets without PSA progression (discordance) and ARAT/docetaxel therapy
., abiraterone and
enzalutamide
) may be susceptible to discordant progression. With the incorporation of early ARAT in SOC, we may see this number rise.
., abiraterone and
enzalutamide
) may be susceptible to discordant progression. With the incorporation of early ARAT in SOC, we may see this number rise.
SeosamhM
in
Advanced Prostate Cancer
11 months ago
Monoamine oxidase A (MAOA): A promising target for prostate cancer therapy
"Furthermore, targeting MAOA can disrupt the crosstalk between MAOA and the androgen receptor (AR)
to restore
sensitivity, blocks glucocorticoid receptor (GR)- and AR-dependent PCa cell growth, and is a potential strategy for immune checkpoint inhibition, thereby alleviating immune
"Furthermore, targeting MAOA can disrupt the crosstalk between MAOA and the androgen receptor (AR)
to restore
sensitivity, blocks glucocorticoid receptor (GR)- and AR-dependent PCa cell growth, and is a potential strategy for immune checkpoint inhibition, thereby alleviating immune
pjoshea13
in
Fight Prostate Cancer
1 year ago
Xtandi.....(enzalutamide tablets)
I have received my medication, and it is Xtandi, not Erleada which I thought it would be from the brochure I received from the physician.....Anyone using this stuff.....and if you will.....what's the "scoop" on this stuff..........thanks......I will start this in early May
I have received my medication, and it is Xtandi, not Erleada which I thought it would be from the brochure I received from the physician.....Anyone using this stuff.....and if you will.....what's the "scoop" on this stuff..........thanks......I will start this in early May
eddieboy52
in
Advanced Prostate Cancer
1 year ago
Xtandi (enzalutamide) +ADT slows metastases in recurrent men
https://www.prostatecancer.news/2023/05/xtandi-
enzalutamide
-adt-slows.html Early treatment with either may allow extended ADT vacations.
https://www.prostatecancer.news/2023/05/xtandi-
enzalutamide
-adt-slows.html Early treatment with either may allow extended ADT vacations.
Tall_Allen
in
Advanced Prostate Cancer
1 year ago
Second generation androgen receptor antagonists and challenges in prostate cancer treatment
Also covers some new generation AR antagonist Proxalutamide (GT-0918) is a full AR antagonist which has 3-fold higher binding affinity in comparison with
enzalutamide
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304354/
Also covers some new generation AR antagonist Proxalutamide (GT-0918) is a full AR antagonist which has 3-fold higher binding affinity in comparison with
enzalutamide
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304354/
KocoPr
in
Advanced Prostate Cancer
2 years ago
Phase 1b trial shows reformulated Niclosamide has promise for CRPC
•Preclinical findings suggest that AR-V7 inhibition alone cannot explain the magnitude of antitumor effects of niclosamide, either used alone or in combination with abiraterone or
enzalutamide
. •Niclosamide, a well known mitochondrial uncoupler, has pleiotropic effects.
•Preclinical findings suggest that AR-V7 inhibition alone cannot explain the magnitude of antitumor effects of niclosamide, either used alone or in combination with abiraterone or
enzalutamide
. •Niclosamide, a well known mitochondrial uncoupler, has pleiotropic effects.
Graham49
in
Advanced Prostate Cancer
1 year ago
PCa spread to Liver
He is currently on
Enzalutamide
+ hormone injections(monthly) and has had 6 rounds of chemo (Docetaxel) finished in first week of March 2023.
He is currently on
Enzalutamide
+ hormone injections(monthly) and has had 6 rounds of chemo (Docetaxel) finished in first week of March 2023.
A-rat-22
in
Advanced Prostate Cancer
1 year ago
Alternative to Zytiga/Abiraterone?
Would the appropriate alternative be to substitute
Enzalutamide
or Docetaxel for the Abiraterone? Or, maybe just drop the Abiraterone, not replace it, and just do Lupron with radiation??? Other than aggressive prostate cancer, he’s slim, fit, active, an athlete, and healthy.
Would the appropriate alternative be to substitute
Enzalutamide
or Docetaxel for the Abiraterone? Or, maybe just drop the Abiraterone, not replace it, and just do Lupron with radiation??? Other than aggressive prostate cancer, he’s slim, fit, active, an athlete, and healthy.
Adendino
in
Advanced Prostate Cancer
1 year ago
No relief for Xtandi Prices
Health and Human Services (HHS) Secretary Xavier Becerra to grant march-in rights—under which the government can grant patent licenses to companies other than a drug's manufacturer—for
enzalutamide
, which is sold under the brand name Xtandi by Pfizer and Japanese pharmaceutical giant Astellas.
Health and Human Services (HHS) Secretary Xavier Becerra to grant march-in rights—under which the government can grant patent licenses to companies other than a drug's manufacturer—for
enzalutamide
, which is sold under the brand name Xtandi by Pfizer and Japanese pharmaceutical giant Astellas.
Magnus1964
in
Advanced Prostate Cancer
1 year ago
Elreada: minimal effective dose
Before Elreada came along I was thinking, if forced, that I would opt for
Enzalutamide
but prefering to go with a shot at a minimal effectiv dose of half or a quarter as some have recorded here and elsewhere. Now I am thinking that I might go for Elreada.
Before Elreada came along I was thinking, if forced, that I would opt for
Enzalutamide
but prefering to go with a shot at a minimal effectiv dose of half or a quarter as some have recorded here and elsewhere. Now I am thinking that I might go for Elreada.
Rickytarr
in
Fight Prostate Cancer
1 year ago
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