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Diphenhydramine

About diphenhydramine

Diphenhydramine is an antihistamine medicine that relieves the symptoms of allergies. It's known as a drowsy (sedating) antihistamine and is more likely to make you feel sleepy than other antihistamines. It's used for:

  • short-term sleep problems (insomnia), including when a cough, cold or itching is keeping you awake at night
  • cough and cold symptoms
  • hay fever
  • eczema, hives (urticaria) and insect bites and stings

You can buy diphenhydramine from pharmacies and it is also available on prescription.

It comes as tablets and a liquid that you swallow. For skin allergies like hives or bites and stings it's also available as a cream. The cream is much less likely to make you feel sleepy than the tablets or liquid.

You can also buy it mixed with other medicines, such as levomenthol, paracetamol, pholcodine and pseudoephedrine, to treat cough and cold symptoms.

Who can and cannot take diphenhydramine

Diphenhydramine can be taken by most adults and young people aged 16 years and above. You can sometimes give diphenhydramine to children, depending on their age and their symptoms. Ask your pharmacist for advice.

For cough and cold symptoms, you can give diphenhydramine tablets and liquid to children over the age of 6. For allergy symptoms, you can give it to children over 12. Check with your pharmacist or doctor to make sure a product is suitable for your child.

You can also use diphenhydramine cream on children for:

  • insect bites and stings
  • eczema

Do not give your child diphenhydramine to help them get to sleep. Diphenhydramine is only suitable for sleep problems in people aged 16 years and above.

Diphenhydramine is not suitable for some people. To make sure it's safe for you, tell your doctor or pharmacist if you:

  • have ever had an allergic reaction to diphenhydramine or any other medicine
  • have lung problems, such as asthma or chronic obstructive pulmonary disease (COPD), or an illness that creates a lot of phlegm
  • have an eye problem called primary angle closure glaucoma
  • have a blockage in your stomach or gut
  • have kidney or liver problems
  • have problems peeing or emptying your bladder
  • have epilepsy or any other health problem that causes fits (seizures)
  • are due to have an allergy test – diphenhydramine can affect your results, so you may need to stop taking it a few days before your test – ask a pharmacist or your doctor for advice
  • are unable to have any alcohol – some liquid diphenhydramine products contain a small amount of alcohol, so check the ingredients and the packaging carefully

How and when to take or use diphenhydramine

If you or your child have been prescribed diphenhydramine, follow your doctor's instructions about how and when to take it.

Only take or use diphenhydramine when you need it, for example if you're unable to sleep because you're worrying about something or your cold symptoms are keeping you awake.

If you've bought diphenhydramine or any medicine containing diphenhydramine from a pharmacy, follow the instructions that come with the packet, or ask a pharmacist for advice.

The instructions will be different depending on the type of medicine you buy, and the other medicines it's mixed with.

If you're aged over 65, start with the lower dose, as you may be more likely to get side effects.

The usual dose depends on the type of diphenhydramine medicine you're taking, and why.

Dosage for short-term insomnia

Diphenhydramine comes as 25mg and 50mg tablets. You'll usually take 50mg, 20 minutes before you go to bed.

Dosage for cough and cold symptoms

Diphenhydramine comes mixed with other medicines to treat the symptoms of coughs and colds. It comes as tablets and as a liquid that you swallow. The usual dose depends on the type of medicine you're taking. Check the instructions on the packaging carefully, or ask your doctor or pharmacist if you're unsure.

Dosage for hay fever and allergies

Diphenhydramine comes as 25mg and 50mg tablets. The usual dose is 25mg or 50mg, taken 3 or 4 times a day. Try to space your doses evenly throughout the day.

Dosage for insect bites, stings and eczema

Diphenhydramine comes as a cream which you use once or twice a day. You'll only need a small amount, enough for a thin layer.

How to take or use it

You can take diphenhydramine tablets and liquid with or without food.

How to take diphenhydramine tablets

Always take your diphenhydramine tablets with a drink of water. Swallow them whole. Do not chew them.

How to take diphenhydramine liquid

Liquid medicines containing diphenhydramine come with a plastic syringe or spoon to help you measure the right dose. If you do not have a syringe or spoon, ask your pharmacist for one. Do not use a kitchen teaspoon as it will not measure the right amount.

How to use diphenhydramine cream

With the cream, put a small amount onto the affected area and smooth it in gently. Do not use it on large areas of skin. Keep the cream away from your eyes, mouth and nose. Remember to wash your hands afterwards, unless you're treating your hands.

What if I forget to take or use it?

If you're taking diphenhydramine to help you sleep and you forget to take it by bedtime, skip your missed dose and start again the next evening.

If you're taking any other medicine containing diphenhydramine and forget to take a dose, take your medicine when you next need it to ease your symptoms.

Never take 2 doses at the same time. Never take an extra dose to make up for a forgotten one.

If you forget doses often, it may help to set an alarm to remind you. You could also ask your pharmacist for advice on other ways to help you remember to take your medicine.

What if I take or use too much?

Too much diphenhydramine can be dangerous.

If you've taken more than the usual dose you may:

  • feel very sleepy
  • feel sick (nauseous)
  • get blurry eyesight
  • feel your heart beating very fast

In serious cases you can become unconscious and may need emergency treatment in hospital.

Do not use diphenhydramine cream at the same time as other products containing diphenhydramine. This can lead to overdose.

  • you take more than your prescribed dose of diphenhydramine

Go to 111.nhs.uk or call 111

If you need to go to A&E, do not drive yourself. Get someone else to drive you or call for an ambulance.

Take the diphenhydramine packet or leaflet inside it plus any remaining medicine with you.

Side effects

Like all medicines, diphenhydramine can cause side effects, although not everyone gets them. However, you may be more likely to get them if you're over 65.

Common side effects happen in more than 1 in 100 people. Talk to your doctor or pharmacist if these side effects bother you or do not go away:

  • feeling sleepy, or drowsy, during the daytime
  • dry mouth
  • feeling dizzy or unsteady on your feet, or having difficulty concentrating

Diphenhydramine cream can sometimes make your rash worse. It may also make your skin sensitive to sunlight.

Serious side effects

  • you have a fast or irregular heartbeat (palpitations)
  • you feel any numbness or pins and needles
  • you feel confused or very restless
  • you or child has had a seizure or fit

In rare cases, it's possible to have a serious allergic reaction (anaphylaxis) to diphenhydramine.

These are not all the side effects of diphenhydramine. For a full list, see the leaflet inside your medicine packet.

How to cope with side effects of diphenhydramine

What to do about:

  • feeling sleepy, or drowsy, during the daytime – drowsiness usually wears off 8 hours after a dose. Do not drive, ride a bike or use tools or machinery if you're feeling this way.
  • dry mouth – chew sugar-free gum or suck sugar-free sweets.
  • feeling dizzy or unsteady on your feet, or difficulty concentrating – if diphenhydramine makes you feel this way, stop what you're doing and sit or lie down until you feel better. If the feeling does not go away or is worrying you, do not take any more medicine and speak to a pharmacist or your doctor.

Pregnancy and breastfeeding

While diphenhydramine can be used during pregnancy, it is not normally recommended. This is because of the side effects, which may be more significant during pregnancy. Discuss with your doctor or pharmacist other medicines, such as chlorphenamine, that may more suitable.

If you have difficulty sleeping while you're pregnant, your doctor or midwife may suggest ways to improve your sleep routine, like relaxing, and avoiding naps.

If you have a cough or cold, you can help to ease your symptoms by resting, drinking plenty of fluids and taking paracetamol.

Diphenhydramine and breastfeeding

If your doctor or health visitor says your baby is healthy, you can take diphenhydramine while you're breastfeeding, but it's better to take occasional doses or only take it for a short time.

Diphenhydramine passes into breast milk in very small amounts. Although it's unlikely to cause any side effects in your baby, it is a drowsy antihistamine, so could make your baby sleepy.

If you're breastfeeding, or planning to breastfeed, talk to your doctor. They may recommend similar antihistamines, called loratadine and cetirizine, that are more suitable while you're breastfeeding.

Talk to your doctor, pharmacist, midwife or health visitor if your baby is not feeding as well as usual, seems unusually sleepy, seems irritable, or if you have any other concerns about your baby.

Cautions with other medicines

Some medicines can affect the way diphenhydramine works, and increase the chances of you having side effects. Check with your pharmacist or doctor if you're taking:

  • antidepressants, such as venlafaxine or a monoamine oxidase inhibitor such as phenelzine
  • metoprolol, a heart medicine
  • any medicine that makes you drowsy, gives you a dry mouth, or makes it difficult for you to pee – taking diphenhydramine might make these side effects worse

If you're taking a cough or cold remedy or a painkiller containing diphenhydramine, check carefully what the other ingredients are. For example, check whether it contains paracetamol. Ask your pharmacist for advice before you take this medicine together with any other painkillers or medicines.

There might be a problem taking some herbal remedies and supplements alongside diphenhydramine, especially ones that cause side effects such as sleepiness, a dry mouth or making it difficult to pee.

Related links

Atopic eczema — Link to Related Condition

Contact dermatitis — Link to Related Condition

Hay fever — Link to Related Condition

Hives — Link to Related Condition

Insect bites and stings — Link to Related Condition

Insomnia — Link to Related Condition

HealthUnlocked: diphenhydramine forum — Link to Useful Resource

Allergy UK: charity — Link to Useful Resource

Healthtalk: videos of real stories about sleep problems — Link to Useful Resource

Itchy Sneezy Wheezy: website for parents — Link to Useful Resource

HealthUnlocked contains information from NHS Digital, licensed under the current version of the Open Government Licence

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38 public posts

INSOMNIA

I would like to know if i can take Benadryl (diphenhydramine hydrochloride) for sleep if i have CKD stage 3B? The research on this is very confusing. Some sites say it's OK; others say it's bad. Any other suggestions for sleep aids?
I would like to know if i can take Benadryl (diphenhydramine hydrochloride) for sleep if i have CKD stage 3B? The research on this is very confusing. Some sites say it's OK; others say it's bad. Any other suggestions for sleep aids?
Starcatty profile image
Starcatty
in Kidney Disease
2 months ago

Zolpidem users: a debilitating surprise awaits at 65

Note: My time-fitting (4 hours sleep to go) nights, OTC substitute -- Diphenhydramine: https://www.medicalnewstoday.com/articles/288546#Taking-anticholinergics-for-more-than-3-years-linked-to-higher-dementia-risk I also wake up from Diphenhydramine feeling like I’ve been hit by a truck.
Note: My time-fitting (4 hours sleep to go) nights, OTC substitute -- Diphenhydramine: https://www.medicalnewstoday.com/articles/288546#Taking-anticholinergics-for-more-than-3-years-linked-to-higher-dementia-risk I also wake up from Diphenhydramine feeling like I’ve been hit by a truck.
Patrickk profile image
Patrickk
in Sleep Matters
4 months ago

Alpha Gal Syndrome & Propylene glycol Allergy

So far I have found none other than Unison melts (diphenhydramine) but causes sleepiness and Restless legs..
So far I have found none other than Unison melts (diphenhydramine) but causes sleepiness and Restless legs..
Met58 profile image
Met58
in Allergic to Glycols
1 year ago
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Superdrug one a night sleep aid

Taking 50mg of diphenhydramine hydrochloride every night to help me sleep. This is an over the counter med. Have been taking it for nearly two months. Have tried sleeping without it and I am awake for hours because of the tinnitus. Mine is a high pitched squealing in both ears.
Taking 50mg of diphenhydramine hydrochloride every night to help me sleep. This is an over the counter med. Have been taking it for nearly two months. Have tried sleeping without it and I am awake for hours because of the tinnitus. Mine is a high pitched squealing in both ears.
Catlioness41 profile image
Catlioness41
in British Tinnitus Association
2 years ago

Overusing over the counter meds

Around 3 years ago I discovered Nytol (diphenhydramine) and have been taking them pretty much every day since to help me nap and sleep on a night time. I struggle with both anxiety and depression and sometimes sleep feels like the best solution to problems. I always seem to wake up happier.
Around 3 years ago I discovered Nytol (diphenhydramine) and have been taking them pretty much every day since to help me nap and sleep on a night time. I struggle with both anxiety and depression and sometimes sleep feels like the best solution to problems. I always seem to wake up happier.
emcg96 profile image
emcg96
in Anxiety Support
1 year ago

BEST PRESCRIPTION SLEED AID

I stopped taking Diphenhydramine as a sleep aid after reading all the negative effects it has on rls. Wondering what most people have been prescribed by their Doctor for better sleep.
I stopped taking Diphenhydramine as a sleep aid after reading all the negative effects it has on rls. Wondering what most people have been prescribed by their Doctor for better sleep.
UncleFester profile image
UncleFester
in Restless Legs Syndrome
2 years ago

Something to try if you suffer from the dreaded MPN itches

I tried 4 different antihistamines...hydroxyzine, diphenhydramine, allegra and fenfoxadine...they did absolutely nothing. I read that pepcid could help with hives because it is a H2 receptor antagonist.
I tried 4 different antihistamines...hydroxyzine, diphenhydramine, allegra and fenfoxadine...they did absolutely nothing. I read that pepcid could help with hives because it is a H2 receptor antagonist.
clubdino profile image
clubdino
in MPN Voice
2 years ago

Cycle 1 of Clinical Trials

Next I was given 650 mg of acetaminophen orally and 50 mg of diphenhydramine (Benadryl) IV which I hate the way that feels. Avelumab was infused 30 minutes later over an hour. I felt no side effects during the PT-112 infusion and a very small amount of itching during the avelumab infusion.
Next I was given 650 mg of acetaminophen orally and 50 mg of diphenhydramine (Benadryl) IV which I hate the way that feels. Avelumab was infused 30 minutes later over an hour. I felt no side effects during the PT-112 infusion and a very small amount of itching during the avelumab infusion.
Cleodman profile image
Cleodman
in Advanced Prostate Cancer
3 years ago

Diphenhydramine/antihistamines shortened sleep-wake cycle?

I took 2 Benadryl tablets once 2 months ago to fall asleep earlier. That morning I woke up after only 6 hours of sleep (I usually get 8-9). Every day since then I've been getting only 6 hours of sleep per night, and I feel a strong urge to sleep in the afternoon (but I try not to). How do I reset my
I took 2 Benadryl tablets once 2 months ago to fall asleep earlier. That morning I woke up after only 6 hours of sleep (I usually get 8-9). Every day since then I've been getting only 6 hours of sleep per night, and I feel a strong urge to sleep in the afternoon (but I try not to). How do I reset my
billwright123 profile image
billwright123
in Sleep Matters
2 years ago

Sciatica treatment

As Diphenhydramine contains an antihistamine I am not taking my usual antihistamine XYZAL which I take every day. I know I shouldn’t be surprised with all the combinations of drugs but I am getting very stressed. Thank you
As Diphenhydramine contains an antihistamine I am not taking my usual antihistamine XYZAL which I take every day. I know I shouldn’t be surprised with all the combinations of drugs but I am getting very stressed. Thank you
Bardsea profile image
Bardsea
in IBS Network
3 years ago

Amiodarone & Bisoprolol

This works well and better than Nytol one a night (Diphenhydramine) which if it any help gives me bad RLS.
This works well and better than Nytol one a night (Diphenhydramine) which if it any help gives me bad RLS.
Mike-tyson profile image
Mike-tyson
in AF Association
3 years ago

Sleeping struggle

I have little sleep each and every night and I had to take diphenhydramine every night that I developed dependence. I don’t feel rested at all and I don’t feel sleepy at night. Any thoughts on how to deal with this? Thanks
I have little sleep each and every night and I had to take diphenhydramine every night that I developed dependence. I don’t feel rested at all and I don’t feel sleepy at night. Any thoughts on how to deal with this? Thanks
sed3ntary profile image
sed3ntary
in Sleep Matters
3 years ago

Diphenhydramine

How long does it take for Diphenhydrami ne to leave the system as I want to try another sleep aid?
How long does it take for Diphenhydrami ne to leave the system as I want to try another sleep aid?
jonboy40 profile image
jonboy40
in Sleep Matters
3 years ago

Sominex

I live in the U.K. and Ive just bought a box of Sominex,which says it contains Promethazine HydrochloridePh.Eu.20mgs, surely this is not the same as Diphenhydramine?
I live in the U.K. and Ive just bought a box of Sominex,which says it contains Promethazine HydrochloridePh.Eu.20mgs, surely this is not the same as Diphenhydramine?
jonboy40 profile image
jonboy40
in Sleep Matters
3 years ago

Promethazine/Diphhydramine

Promethazine/Dipenhydramine Can I take Promethazine 2 or 3 nights after Diphenhydramine?
Promethazine/Dipenhydramine Can I take Promethazine 2 or 3 nights after Diphenhydramine?
jonboy40 profile image
jonboy40
in Mental Health Support
3 years ago

Controlling Lesion Pain

That’s 100 ml of the Lidocaine & 60-80 ml of antacid (maalox) and Diphenhydramine HCI (Benadryl) ea. Mix and sip just enough to touch the lesions. Hold in mouth four 5 minutes. 1/4 teaspoon? I usually swallow since I have lesions down in my throat.
That’s 100 ml of the Lidocaine & 60-80 ml of antacid (maalox) and Diphenhydramine HCI (Benadryl) ea. Mix and sip just enough to touch the lesions. Hold in mouth four 5 minutes. 1/4 teaspoon? I usually swallow since I have lesions down in my throat.
Number4 profile image
Number4
in Behçet's UK
4 years ago

Antihistamines reversed tumor-enhancing effects of myeloid-derived suppressor cells

Antihistamines include H1 blockers (loratadine, diphenhydramine, etc,) for allergies treatment, and H2 blockers (Cimetidine, Ranitidine, etc,) for gastric ulcers, gastritis. Here is the finding (kind of old July 2014): To reach their findings, the team analyzed two groups of mice.
Antihistamines include H1 blockers (loratadine, diphenhydramine, etc,) for allergies treatment, and H2 blockers (Cimetidine, Ranitidine, etc,) for gastric ulcers, gastritis. Here is the finding (kind of old July 2014): To reach their findings, the team analyzed two groups of mice.
Ralph1966 profile image
Ralph1966
in Advanced Prostate Cancer
4 years ago

I Gave up Cigs

I have even successfully taken 50mg of Diphenhydramine to help me sleep (oxymoron, huh?). I’m still on Mirapex and plan on going forward with that until something changes. I hope all are having a good day!!
I have even successfully taken 50mg of Diphenhydramine to help me sleep (oxymoron, huh?). I’m still on Mirapex and plan on going forward with that until something changes. I hope all are having a good day!!
LisztLover profile image
LisztLover
in Restless Legs Syndrome
4 years ago

CT Scan with Iodine Contrast

The doctor has prescribed desamethasone (a steroid) for 8 hours and 4 hours before the infusion, and diphenhydramine HCl (Benedryl) 1 hour before. That should take care of the allergic reaction. But b) I have heard that large amounts of iodine can interfere with treatment for hypothyroidism.
The doctor has prescribed desamethasone (a steroid) for 8 hours and 4 hours before the infusion, and diphenhydramine HCl (Benedryl) 1 hour before. That should take care of the allergic reaction. But b) I have heard that large amounts of iodine can interfere with treatment for hypothyroidism.
vocalEK profile image
vocalEK
in Thyroid UK
4 years ago

Introduction

(With large enough doses of Diphenhydramine I could almost completely knock out the tremor. But the side effects weren’t worth it).
(With large enough doses of Diphenhydramine I could almost completely knock out the tremor. But the side effects weren’t worth it).
Georgeofthejungle profile image
Georgeofthejungle
in Cure Parkinson's
4 years ago
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