Cycle 1 of Clinical Trials: Yesterday... - Advanced Prostate...

Advanced Prostate Cancer

22,277 members27,978 posts

Cycle 1 of Clinical Trials

Cleodman profile image
14 Replies

Yesterday was my first round of treatments for a new clinical trial that involves an infusion of a novel platinum based chemotherapy drug currently named PT-112 followed by the immunotherapy drug avelumab.

I had two IV’s placed. One was for the infusions and the other was for blood draws. I started at 0700 and ended at 1600. Zofran (ondansetron) was given 30 minutes before PT-112 then PT-112 over one hour. Serum levels of PT-112 were checked every 2 hours.

Next I was given 650 mg of acetaminophen orally and 50 mg of diphenhydramine (Benadryl) IV which I hate the way that feels. Avelumab was infused 30 minutes later over an hour.

I felt no side effects during the PT-112 infusion and a very small amount of itching during the avelumab infusion.

On a side note I decided on my own to water fast for 2.5 days before the infusions and 1 day after for a total of 85 hours.

I broke out in a fever at around 6 pm last night with body aches and just went to bed. Not feeling my best this morning but hoping that breaking my fast will help.

Written by
Cleodman profile image
Cleodman
To view profiles and participate in discussions please or .
Read more about...
14 Replies
Tall_Allen profile image
Tall_Allen

Ask for Claritin instead of benadryl. Fevers are a danger sign - febrile neutropenia can be life threatening. Can you get Neulasta on your trial?

Cleodman profile image
Cleodman in reply toTall_Allen

I asked for it but I guess will have to play the insurance game and actually show leukopenia/neutropenia before they will actually pay for it. I could not get it prophylacticly. Also there is no IV formulation for Claritin just oral and since the trial is on the clock they need a high dose of antihistamine onboard quickly before the avelumab is given. I hear you though TA!

Thank you Cleodman for doing the trial .. this could help you and many others . I’ve been on a test drug over five years now with great success. The trial failed others but I’ve done well on it . Good luck

. Speedy recovery

Cleodman profile image
Cleodman in reply to

Thanks for the support

j-o-h-n profile image
j-o-h-n in reply toCleodman

How high was your fever? Keep up the good fight........

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 07/25/2020 12:35 PM DST

Cleodman profile image
Cleodman in reply toj-o-h-n

101.1 F

j-o-h-n profile image
j-o-h-n in reply toCleodman

Not too high... Thank God....

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 07/25/2020 3:01 PM DST

Kaliber profile image
Kaliber in reply toj-o-h-n

It’s always better to be higher than your fever ....

Just say’in

j-o-h-n profile image
j-o-h-n in reply toKaliber

and harder.............

Just say’in

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 07/25/2020 2:59 PM DST

Kaliber profile image
Kaliber in reply toj-o-h-n

Yayahahahaya harder ? ...

Check all boxes that apply:

[]. 1. Dreamer

[]. 2. Bragger

[]. 3. Delusional

[]. 4. Shortie

[]. 5. All of the above

😂😂😂😂😂😂

j-o-h-n profile image
j-o-h-n in reply toKaliber

[]. 6. Plastic cast mold model.

😂😂😂😂😂😂

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 07/25/2020 5:45 PM DST

Kaliber profile image
Kaliber in reply toj-o-h-n

You have to admire the man that can stick with it when things are tough down in the trenches. 🍆🌶🥕🍌

treedown profile image
treedown in reply to

Have they been able to identify why your doing well when others are not?

in reply totreedown

I’ve done a lot of stuff beyond what the Doctors said to do . I did twice weekly 50 mgs of vitamin c iv’s for a year and a half ,plus a lot of nutrients . I dropped the S.A.D. Diet and went organic . I was told by my Drs that only 1/3 of stage 4 s go into remission . Just dumb luck I guess . It helps to have love at home ..

Not what you're looking for?

You may also like...

Entering Clinical Trials

My recent biopsy shows no evidence of a new BRAC1/2 mutation so the PARB inhibitors are not an...
Cleodman profile image

4th infusion of immunotherapy drug JANX007

Hello allI had my fourth infusion of this new drug in this clinical trial. The MO and sponsor have...

Risk vs reward in clinical trials

Morning folks, I just finished reading my clinical protocol consent paperwork and don’t get the...
Pmann profile image

Provenge

Finished second infusion. Side effects were similar to first infusion , but didn't last as long. I...
hysir profile image

Second Cycle Of Docetaxol So far

Hi everyone. My husband had his second round of Docetaxol on Monday. He has been feeling extremely...
MelaniePaul profile image

Moderation team

Bethishere profile image
BethishereAdministrator
Number6 profile image
Number6Administrator
Darryl profile image
DarrylPartner

Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.

Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.