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CDNF, Potential DMT for Parkinson’s, May Work as Nasal Spray
A potential Parkinson’s therapy based on a protein with an ability to protect neurons — called recombinant (lab-made) human cerebral dopamine neurotrophic factor (rhCDNF) — has been transformed into tiny nanoparticles that may allow for its use as a nasal spray, Herantis Pharma, its developer, announced
A potential Parkinson’s therapy based on a protein with an ability to protect neurons — called recombinant (lab-made) human cerebral dopamine neurotrophic factor (rhCDNF) — has been transformed into tiny nanoparticles that may allow for its use as a nasal spray, Herantis Pharma, its developer, announced
Hidden
in
Cure Parkinson's
3 years ago
The Thermodynamic Consequences of Parkinson's Disease
Several lines of evidence point to a pervasive disturbance of energy balance in Parkinson's disease (PD). Weight loss, common and multifactorial, is the most observable sign of this. Bradykinesia may be best understood as an underinvestment of energy in voluntary movement. This accords with rodent experiments
Several lines of evidence point to a pervasive disturbance of energy balance in Parkinson's disease (PD). Weight loss, common and multifactorial, is the most observable sign of this. Bradykinesia may be best understood as an underinvestment of energy in voluntary movement. This accords with rodent experiments
Farooqji
in
Cure Parkinson's
3 years ago
Gabapentin not working as yet
Hi Ive been on gabapentin for 5 weeks now. I previously posted saying my doctor had prescribed 100mgs 3 times daily. I was advised on forum as I thought, that this dose was useless, and I'd be better taking at night and upping dose gradually. So I'm now to to 900mgs at night but still not seeing
Hi Ive been on gabapentin for 5 weeks now. I previously posted saying my doctor had prescribed 100mgs 3 times daily. I was advised on forum as I thought, that this dose was useless, and I'd be better taking at night and upping dose gradually. So I'm now to to 900mgs at night but still not seeing
Lizzybuz27
in
Restless Legs Syndrome
3 years ago
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DHEA/Cortisol Ratio is Low
I recently had serum, saliva and urine tests to confirm an elevated cortisol diurnal. My ACTH has been elevated for the past 6 months and it has thrown me off w/thyroid meds (Synthroid). I was on 75, then on 50, now on 62.5 consistently for 8+ weeks. I really don't know what's happening with the ACTH
I recently had serum, saliva and urine tests to confirm an elevated cortisol diurnal. My ACTH has been elevated for the past 6 months and it has thrown me off w/thyroid meds (Synthroid). I was on 75, then on 50, now on 62.5 consistently for 8+ weeks. I really don't know what's happening with the ACTH
marvalrus
in
Thyroid UK
3 years ago
My solution for RLS
Last year i got rls syndrome and very bad symptoms, didnt sleep all nights, mostly 2,5 hours interrupted. Totally panicked thinking this would be my life. it was horible. Looked into the medicines but found as a highly sensitive person I probably would get a lot of the side effects so decided not to
Last year i got rls syndrome and very bad symptoms, didnt sleep all nights, mostly 2,5 hours interrupted. Totally panicked thinking this would be my life. it was horible. Looked into the medicines but found as a highly sensitive person I probably would get a lot of the side effects so decided not to
silvia10
in
Restless Legs Syndrome
3 years ago
no one size fits all
I'm sure that I'm not on my own when I say that the land of ADHD is full of interesting mazes with no exits signs. I was diagnosed as an older adult and consequently medicated with Adderall. The effects of the drug are largely positive, though I think my body has built up a tolerance to it over time
I'm sure that I'm not on my own when I say that the land of ADHD is full of interesting mazes with no exits signs. I was diagnosed as an older adult and consequently medicated with Adderall. The effects of the drug are largely positive, though I think my body has built up a tolerance to it over time
TAJB
in
CHADD's Adult ADHD Support
3 years ago
Stopping meds
I wanted to see what the effects might be. How soon does the body deteriorate after stopping L-Dopa? I stopped Rytary 9 days ago. I've had two mild bouts of dizziness. And as can be seen on this shopping list my hand writing has gone from bad to worse. I wondered if there might be withdrawal
I wanted to see what the effects might be. How soon does the body deteriorate after stopping L-Dopa? I stopped Rytary 9 days ago. I've had two mild bouts of dizziness. And as can be seen on this shopping list my hand writing has gone from bad to worse. I wondered if there might be withdrawal
kaypeeoh
in
Cure Parkinson's
3 years ago
Niagen alleviates Parkinson’s disease symptoms but downregulates dopamine metabolism?
I understand that the B3 study used Niacin, but I was researching NR and found this report from March showing eventually NR lowers dopamine (based on worms and mice). Now I'm wondering if this might apply to Niacin also? (I still take 250 mg of Niacin at night and 50 mg more in the afternoon. "We
I understand that the B3 study used Niacin, but I was researching NR and found this report from March showing eventually NR lowers dopamine (based on worms and mice). Now I'm wondering if this might apply to Niacin also? (I still take 250 mg of Niacin at night and 50 mg more in the afternoon. "We
Bolt_Upright
in
Cure Parkinson's
3 years ago
Balance with dopamine / choline receptors
Parkinson do we need to supplement choline or do we have to much choline, if we are not making dopamine will it cause to much choline and is that what causes tremors? I tried entacapone for 4 days and gave me dysknesia, I even cut pill in half, it seemed worse in the morning , I'm thinking my ER night
Parkinson do we need to supplement choline or do we have to much choline, if we are not making dopamine will it cause to much choline and is that what causes tremors? I tried entacapone for 4 days and gave me dysknesia, I even cut pill in half, it seemed worse in the morning , I'm thinking my ER night
akgirlsrock
in
Cure Parkinson's
3 years ago
PART 2 : Reversing Memory Deficits And Senior Moments In A 78 Year Old
In case you missed part 1, here is a link to that post which explains how this supplement plan helped a person with memory issues : https://healthunlocked.com/cure-parkinsons/posts/144327704/part-1-reversing-memory-deficits-and-senior-moments-in-a-78-year-old The reason I am writing this second part
In case you missed part 1, here is a link to that post which explains how this supplement plan helped a person with memory issues : https://healthunlocked.com/cure-parkinsons/posts/144327704/part-1-reversing-memory-deficits-and-senior-moments-in-a-78-year-old The reason I am writing this second part
chartist
in
Cure Parkinson's
3 years ago
Apitherapy for Parkinson’s Disease: A Focus on the Effects of Propolis and Royal Jelly - 2020
I switched from Google to DuckDuckGo and found this surprising article. https://www.hindawi.com/journals/omcl/2020/1727142/ 5. Evidence from Preclinical Studies The effects of both propolis and its flavonoids and RJ and its lipids on PD were examined both in vivo and in vitro. The findings indicate that
I switched from Google to DuckDuckGo and found this surprising article. https://www.hindawi.com/journals/omcl/2020/1727142/ 5. Evidence from Preclinical Studies The effects of both propolis and its flavonoids and RJ and its lipids on PD were examined both in vivo and in vitro. The findings indicate that
Bolt_Upright
in
Cure Parkinson's
3 years ago
Nitrazepam
To help me sleep occasionally, I take half a Nitrazepam 5mg tablet about every 7-10 days, which has been effective up to now. I am reading on here that dopamine agents can make RLS worse over time. Is it safe to moderate it like I do (i.e. about half a tablet every 7-10 days) without getting any adverse
To help me sleep occasionally, I take half a Nitrazepam 5mg tablet about every 7-10 days, which has been effective up to now. I am reading on here that dopamine agents can make RLS worse over time. Is it safe to moderate it like I do (i.e. about half a tablet every 7-10 days) without getting any adverse
oceanred
in
Restless Legs Syndrome
3 years ago
Serum tsh level doubled
As suggested by the forum I had more comprehensive tests done on my thyroid function following the hemithyroidectomy in April 21. These are my results from tests done early morning before eating and before taking my parkinson's medication which includes levadopa and a dopamine agonist (Ropinorole).
As suggested by the forum I had more comprehensive tests done on my thyroid function following the hemithyroidectomy in April 21. These are my results from tests done early morning before eating and before taking my parkinson's medication which includes levadopa and a dopamine agonist (Ropinorole).
Quiltyqueen
in
Thyroid UK
3 years ago
Should I pursue teaching or another career?
I’m currently enrolling for the elementary education k-5 degree to be a teacher. Things I noticed today at our summer program for school age kids. We were playing monopoly and I get hyper focused where I wanted to keep playing when another student needs help with something such as ironing fusebeads and
I’m currently enrolling for the elementary education k-5 degree to be a teacher. Things I noticed today at our summer program for school age kids. We were playing monopoly and I get hyper focused where I wanted to keep playing when another student needs help with something such as ironing fusebeads and
Boxer4ever
in
CHADD's Adult ADHD Support
3 years ago
Why Does High Dose Thiamine Work?
I like to keep challenging the items in my stack. HDT is in my stack. I believe in HDT. But why? So far I trust HDT because of the results from Dr Constantini and the testimonials. Time to look for some science: Neurological, Psychiatric, and Biochemical Aspects of Thiamine Deficiency in Children
I like to keep challenging the items in my stack. HDT is in my stack. I believe in HDT. But why? So far I trust HDT because of the results from Dr Constantini and the testimonials. Time to look for some science: Neurological, Psychiatric, and Biochemical Aspects of Thiamine Deficiency in Children
Bolt_Upright
in
Cure Parkinson's
3 years ago
We need to move more quickly to focused ultrasound (FUS)
About half a century ago, the merrRAdical profession established carbidopa/levodopa as the standard treatment for Parkinson’s disease; and it has been so ever since. But replacing dopamine is not a cure, does not always work, and can lose effectiveness over time. Research went on in many areas,
About half a century ago, the merrRAdical profession established carbidopa/levodopa as the standard treatment for Parkinson’s disease; and it has been so ever since. But replacing dopamine is not a cure, does not always work, and can lose effectiveness over time. Research went on in many areas,
jack-edmonston
in
Cure Parkinson's
3 years ago
Chemical in essential oils may treat Parkinson's disease
Chemical in essential oils may treat Parkinson's disease https://www.medicalnewstoday.com/articles/chemical-in-essential-oils-may-treat-parkinsons-disease A study has found that farnesol, which people use in perfumery and is a component of many essential oils, preserves dopamine nerves in a mouse model
Chemical in essential oils may treat Parkinson's disease https://www.medicalnewstoday.com/articles/chemical-in-essential-oils-may-treat-parkinsons-disease A study has found that farnesol, which people use in perfumery and is a component of many essential oils, preserves dopamine nerves in a mouse model
Patrickk
in
Cure Parkinson's
3 years ago
What comes second to dopamine?
To the extent that the symptoms shown by PwP are caused by shortages or excesses of neurotransmitters what one comes after dopamine as the one most directly linked to PD. For a gentle introduction into the various neurotransmitters, see: https://www.medicalnewstoday.com/articles/326649 John
To the extent that the symptoms shown by PwP are caused by shortages or excesses of neurotransmitters what one comes after dopamine as the one most directly linked to PD. For a gentle introduction into the various neurotransmitters, see: https://www.medicalnewstoday.com/articles/326649 John
johntPM
in
Cure Parkinson's
3 years ago
Intensive meditation practice triggers RLS
About 9 years ago, I took up meditation. It has helped me tremendously face life's challenges, and brought incredible moments of happiness and spiritual insight. I have not missed a day in the past 9 years, and have participated in several (14) intensive retreats, from 6 to 17 days in length. During
About 9 years ago, I took up meditation. It has helped me tremendously face life's challenges, and brought incredible moments of happiness and spiritual insight. I have not missed a day in the past 9 years, and have participated in several (14) intensive retreats, from 6 to 17 days in length. During
BAK524
in
Restless Legs Syndrome
3 years ago
View Point: Disease Modification and Cell Secretome Based Approaches in Parkinson’s Disease: Are We on the Right Track?
To date, clinical testing of disease-modifying treatments has focused on substitution or repair of the remaining dopamine synthesizing neurons following diagnosis. At diagnosis, many of the still surviving and functioning, but already affected neurons have lost most of their axons and are primed for
To date, clinical testing of disease-modifying treatments has focused on substitution or repair of the remaining dopamine synthesizing neurons following diagnosis. At diagnosis, many of the still surviving and functioning, but already affected neurons have lost most of their axons and are primed for
Farooqji
in
Cure Parkinson's
3 years ago
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