What comes second to dopamine?: To the... - Cure Parkinson's

Cure Parkinson's

26,583 members27,899 posts

What comes second to dopamine?

johntPM profile image
13 Replies

To the extent that the symptoms shown by PwP are caused by shortages or excesses of neurotransmitters what one comes after dopamine as the one most directly linked to PD.

For a gentle introduction into the various neurotransmitters, see: medicalnewstoday.com/articl...

John

Written by
johntPM profile image
johntPM
To view profiles and participate in discussions please or .
Read more about...
13 Replies
park_bear profile image
park_bear

Acetylcholine a candidate since anticholinergics can aggravate symptoms.

KERRINGTON profile image
KERRINGTON in reply topark_bear

I'm researching right now, but off hand do you know of any foods, or supplements that are anticholinergic ?

park_bear profile image
park_bear in reply toKERRINGTON

Not foods or supplements but here is a list:

healthline.com/health/antic...

Diphenhydramine aka Benadryl is one that I have observed aggravates my symptoms.

KERRINGTON profile image
KERRINGTON in reply topark_bear

Thanks...also found info from The California Poison Control System on anticholinergic plants, apparently nightshades tomato, eggplant and potatoes too, but mildly.

bassofspades profile image
bassofspades

Serotonin

johntPM profile image
johntPM

Thanks for your replies. So far, we have mentions of serotonin and acetylcholine.

I've had PD for 16 years now, and this is the first time that I've looked at either of these.

According to Parkinson's UK:

parkinsons.org.uk/informati...

"Anticholinergics block a chemical messenger called acetylcholine which is found in your brain and body. It helps to send messages in the brain as well as from your nerves to your muscles."

"In Parkinson’s the effect of acetylcholine is stronger. This can lead to part of the brain becoming overactive and you may experience a tremor. Reducing the effect of acetylcholine can help to treat tremor."

but ...

"Anticholinergics are not often given to people with Parkinson’s because they can cause memory problems or make existing problems worse. This can happen at any age, but particularly for older people."

Resano profile image
Resano in reply tojohntPM

There are complex chemical cascades. Bassofspades cogently suggested Serotonin and I would be tempted to follow him. As for tremor, keep in mind that :"depletion of pallidal dopamine (and possibly serotonin) causes pathological activity in the striato-pallidal circuit that triggers—through the motor cortex—tremor-related activity in the cerebello-thalamo-cortical circuit." (Helmich et al 2012).

Smittybear7 profile image
Smittybear7 in reply tojohntPM

Where can you get a neuro transmitter test. My neurologist wasn't interested in information. There is a company called Dr data neurotransmitter test but you have to have a dr referral. Appreciate any suggestions

JohnPepper profile image
JohnPepper

Exercise!

bassofspades profile image
bassofspades

Monoamine neurotransmitter flowchart

Monoamine neurotransmitter flowchart
Smittybear7 profile image
Smittybear7

How can I find a doctor that will test the neurotransmitters in Pittsburgh Pennsylvania?

gaga1958 profile image
gaga1958 in reply toSmittybear7

Go to a functional doctor

Smittybear7 profile image
Smittybear7 in reply togaga1958

It's difficult trying to find a functional doctor that works with Parkinson patients. If you know of any in Pittsburgh Pennsylvania I'd appreciate if you'd pass their name along. Thanks for your help

Not what you're looking for?

You may also like...

IF PD dopamine LOW, excess transporter proteins get dumped at cell reducing SIGNALLING, UNTIL CELL STOPS WORKING not dead maybe??

lewy bodies develop eventually on cell wall like a battery plates phosphate up when not...
professor profile image

Dopamine

Dopamine - an important signaling substance in our brains By Guest Chronicle on 2013/05/27 · 6...
Gussilago profile image

Don't keep fixating on dopamine to alleviate your lack of energy.

Dopamine is just one(1) neurotransmitter within your system's complex of neurotransmitters....
sharoncrayn profile image

Stimulating dopamine production

I used to naively think one 'used up' dopamine when one moved. After all you need dopamine to move,...
Dap1948 profile image

dopamine club!

Hi! I’m at the end of the road for CL. Can’t take more and can’t boost it more. And only get 10...
Gallowglass profile image

Moderation team

See all
CPT_Aleksandra profile image
CPT_AleksandraAdministrator
CPT_Anaya profile image
CPT_AnayaAdministrator

Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.

Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.