To the extent that the symptoms shown by PwP are caused by shortages or excesses of neurotransmitters what one comes after dopamine as the one most directly linked to PD.
For a gentle introduction into the various neurotransmitters, see: medicalnewstoday.com/articl...
John
Acetylcholine a candidate since anticholinergics can aggravate symptoms.
I'm researching right now, but off hand do you know of any foods, or supplements that are anticholinergic ?
Not foods or supplements but here is a list:
healthline.com/health/antic...
Diphenhydramine aka Benadryl is one that I have observed aggravates my symptoms.
Thanks...also found info from The California Poison Control System on anticholinergic plants, apparently nightshades tomato, eggplant and potatoes too, but mildly.
Serotonin
Thanks for your replies. So far, we have mentions of serotonin and acetylcholine.
I've had PD for 16 years now, and this is the first time that I've looked at either of these.
According to Parkinson's UK:
parkinsons.org.uk/informati...
"Anticholinergics block a chemical messenger called acetylcholine which is found in your brain and body. It helps to send messages in the brain as well as from your nerves to your muscles."
"In Parkinson’s the effect of acetylcholine is stronger. This can lead to part of the brain becoming overactive and you may experience a tremor. Reducing the effect of acetylcholine can help to treat tremor."
but ...
"Anticholinergics are not often given to people with Parkinson’s because they can cause memory problems or make existing problems worse. This can happen at any age, but particularly for older people."
There are complex chemical cascades. Bassofspades cogently suggested Serotonin and I would be tempted to follow him. As for tremor, keep in mind that :"depletion of pallidal dopamine (and possibly serotonin) causes pathological activity in the striato-pallidal circuit that triggers—through the motor cortex—tremor-related activity in the cerebello-thalamo-cortical circuit." (Helmich et al 2012).
Where can you get a neuro transmitter test. My neurologist wasn't interested in information. There is a company called Dr data neurotransmitter test but you have to have a dr referral. Appreciate any suggestions
Exercise!
How can I find a doctor that will test the neurotransmitters in Pittsburgh Pennsylvania?
Go to a functional doctor
It's difficult trying to find a functional doctor that works with Parkinson patients. If you know of any in Pittsburgh Pennsylvania I'd appreciate if you'd pass their name along. Thanks for your help
Drowning Us In Dopamine?
Increasing Dopamine receptor density?
Does Melatonin Deplete Dopamine?
Ozempic effects dopamine?
