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Supraphysiological Androgens [SPA] Promote Tumor Suppressive Activity of the AR Through cMYC Repression and Recruitment of the DREAM Complex
New study [1]. I have struggled to understand how Denmeade’s BAT (Bipolar Androgen Therapy) depends on supraphysiological levels of androgen (testosterone = ~2,000 ng/dL), considering that Morgentaler’s saturation model has it that androgen receptors [ARs] have all the testosterone they can use at
New study [1]. I have struggled to understand how Denmeade’s BAT (Bipolar Androgen Therapy) depends on supraphysiological levels of androgen (testosterone = ~2,000 ng/dL), considering that Morgentaler’s saturation model has it that androgen receptors [ARs] have all the testosterone they can use at
pca2004
in
Fight Prostate Cancer
11 months ago
Me again
Hi, here again. He's doing really well. He's out in the chair each day, still hoisted but he was trying to stand and they had to tell him no you're not strong enough yet. Monday he was in the chair when I got there and they didn't put him back to bed until I left. He was getting tired towards the end
Hi, here again. He's doing really well. He's out in the chair each day, still hoisted but he was trying to stand and they had to tell him no you're not strong enough yet. Monday he was in the chair when I got there and they didn't put him back to bed until I left. He was getting tired towards the end
Castleview
in
British Heart Foundation
3 months ago
Oxygen levels
I have had COPD for around 15 years and it is getting steadily worse. I have the normal inhalers , have a air physio device, a nebuliser and recently have been accepted for oxygen therapy. On my last visit to hospital I was given the device that checks your oxygen levels. As I have only had this device
I have had COPD for around 15 years and it is getting steadily worse. I have the normal inhalers , have a air physio device, a nebuliser and recently have been accepted for oxygen therapy. On my last visit to hospital I was given the device that checks your oxygen levels. As I have only had this device
jackwok
in
Lung Conditions Community Forum
3 months ago
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Music therapy
https://www.youtube.com/watch?v=yZsQ1FZtHw0 Most of us know about binaural beats, rife frequencies, rhythmic auditory stimulation, multiple wave oscillation etc and may even find them beneficial. I thought this YT video was interesting though, not least because some years ago I experimented with
https://www.youtube.com/watch?v=yZsQ1FZtHw0 Most of us know about binaural beats, rife frequencies, rhythmic auditory stimulation, multiple wave oscillation etc and may even find them beneficial. I thought this YT video was interesting though, not least because some years ago I experimented with
PDKiwi
in
Cure Parkinson's
3 months ago
wax treatments
having had an appointment with the specialist nurse yesterday I have been referred to occupational therapy for some help with my clawed hands. Really hoping I can get some positive help as I do suffer at times with pain and stiffness despite doing exercises. She also mentioned a wax bath treatment which
having had an appointment with the specialist nurse yesterday I have been referred to occupational therapy for some help with my clawed hands. Really hoping I can get some positive help as I do suffer at times with pain and stiffness despite doing exercises. She also mentioned a wax bath treatment which
Clangerscat
in
Scleroderma & Raynaud's UK (SRUK)
3 months ago
stage 3b/c inoperable non small cell lung cancer. Cannot tolerate durvalumab, (pneumonitis) No mutations - any hope?
hi, Im 57 and was diagnosed with inoperable non small cell lung cancer in October 2022. Since then Ive adopted a dairy, gluten & sugar free diet , organic only & prinipally vegan. I take millions of supplements a day plus Chinese traditional Medicine. I’ve had 3 rounds of chemo, then combined radio
hi, Im 57 and was diagnosed with inoperable non small cell lung cancer in October 2022. Since then Ive adopted a dairy, gluten & sugar free diet , organic only & prinipally vegan. I take millions of supplements a day plus Chinese traditional Medicine. I’ve had 3 rounds of chemo, then combined radio
ohayeai
in
The Roy Castle Lung Cancer Foundation
3 months ago
EP consult
The cardiologist I see is not able to provide medical management of my paroxysmal afib due to my low heart rate and low blood pressure (can't risk pushing either value lower), so I am hoping for an ablation. This morning, due to a cancellation, I was able to bring my initial EP consult forward by 1
The cardiologist I see is not able to provide medical management of my paroxysmal afib due to my low heart rate and low blood pressure (can't risk pushing either value lower), so I am hoping for an ablation. This morning, due to a cancellation, I was able to bring my initial EP consult forward by 1
Desertflowerchild
in
Atrial Fibrillation Support
3 months ago
Things, regimens,etc that are probably RLS worthless.
THINGS THAT DO NOT WORK FOR RLS All of us with RLS/PLMD have slightly different symptoms. We have tried various 'remedies' to try to relieve our RLS symptoms. We have read articles, some interesting, some ridiculous (bar of soap) that make amazing promises. And there is an entire array of things to
THINGS THAT DO NOT WORK FOR RLS All of us with RLS/PLMD have slightly different symptoms. We have tried various 'remedies' to try to relieve our RLS symptoms. We have read articles, some interesting, some ridiculous (bar of soap) that make amazing promises. And there is an entire array of things to
fritz34
in
Restless Legs Syndrome
3 months ago
ONLINE SUPPORT GROUPS
Our support groups are such a good way to connect with other's in a similar situation, they have really helped so many people make friendships and gain valuable knowledge around their treatment and care. If you have any queries about anything please get in touch, we would love to hear from you and help
Our support groups are such a good way to connect with other's in a similar situation, they have really helped so many people make friendships and gain valuable knowledge around their treatment and care. If you have any queries about anything please get in touch, we would love to hear from you and help
ConnectRoyCastle
Administrator
in
The Roy Castle Lung Cancer Foundation
3 months ago
Another update
This is just a reply (edited), not an original post but readers may find it of interest. As far as I know all replies are public and can be viewed by any Enc. member. "To know we are still useful despite our disability is a big bonus. I used to open the curtains on the ward and make my own bed and the
This is just a reply (edited), not an original post but readers may find it of interest. As far as I know all replies are public and can be viewed by any Enc. member. "To know we are still useful despite our disability is a big bonus. I used to open the curtains on the ward and make my own bed and the
Gandalf2
in
Encephalitis Society
3 months ago
Gene therapy
TOP TAKEAWAYSGene therapy has a potential place In the treatment • of Parkinson disease, but won't be the "be all end al as some may think. There are a lot of questions regarding drug development of PD gene therapies, Including which targets are the most promlslng/effectlve. Investlgatlonal right now
TOP TAKEAWAYSGene therapy has a potential place In the treatment • of Parkinson disease, but won't be the "be all end al as some may think. There are a lot of questions regarding drug development of PD gene therapies, Including which targets are the most promlslng/effectlve. Investlgatlonal right now
Farooqji
in
Cure Parkinson's
3 months ago
Lupron unjection not reducing PSA
I was first diagnosed with prostate cancer in 2016. It has been contained in the prostate ever since. For 3 years I treated myself with vitamins and nutrients. Kept my psa down until I had a kidney stone operation and for some odd ball reason loss control of the psa after the operation, it shot up to
I was first diagnosed with prostate cancer in 2016. It has been contained in the prostate ever since. For 3 years I treated myself with vitamins and nutrients. Kept my psa down until I had a kidney stone operation and for some odd ball reason loss control of the psa after the operation, it shot up to
woppaginny
in
Advanced Prostate Cancer
3 months ago
Proton Beam Therapy
Has anyone had Proton Beam Therapy for their prostate cancer. I have read up on it but would like to know some personal experiences from anyone who has had this treatment. Preferably anyone who had proton beam therapy at Penn Medicine at Lancaster General in Lancaster, Pa. but anyone who has experienced
Has anyone had Proton Beam Therapy for their prostate cancer. I have read up on it but would like to know some personal experiences from anyone who has had this treatment. Preferably anyone who had proton beam therapy at Penn Medicine at Lancaster General in Lancaster, Pa. but anyone who has experienced
woppaginny
in
Advanced Prostate Cancer
3 months ago
Oxygen Therapy
Hi Everyone, A relative, who has MS, has suggested that I try oxygen therapy. It seems to really help them but I wondered if anyone here has had any experience of this and provide a suitable comment. Many thanks!
Hi Everyone, A relative, who has MS, has suggested that I try oxygen therapy. It seems to really help them but I wondered if anyone here has had any experience of this and provide a suitable comment. Many thanks!
RLSofManyYears
in
Restless Legs Syndrome
3 months ago
Let's enjoy some predictions: cell and gene therapy in 2024
because sometimes we must also have some positive but realistic dreams.... https://www.massgeneralbrigham.org/en/about/newsroom/articles/2024-predictions-about-gene-and-cell-therapy
because sometimes we must also have some positive but realistic dreams.... https://www.massgeneralbrigham.org/en/about/newsroom/articles/2024-predictions-about-gene-and-cell-therapy
Maxone73
in
Advanced Prostate Cancer
3 months ago
BCF after 9 years post proton therapy
My PSA had been increasing slowly since my nadir of .75 in 2017 reaching 1.19 in 2022. Both RO and Uro weren't terribly concerned. I wanted PSMA after 3rd consecutive increase but both recommended a wait and see approach, especially the RO who seems honor bound to wait for 2.0 over nadir. I skipped
My PSA had been increasing slowly since my nadir of .75 in 2017 reaching 1.19 in 2022. Both RO and Uro weren't terribly concerned. I wanted PSMA after 3rd consecutive increase but both recommended a wait and see approach, especially the RO who seems honor bound to wait for 2.0 over nadir. I skipped
hwrjr
in
Prostate Cancer Network
3 months ago
update Vanderbilt
just thought I would update and let y’all know that I have an appointment with a doctor at Vanderbilt university medical in Franklin Tennessee in April. Vanderbilt is a RLS quality care center and the closest to me. I actually had one of their Doctors call me and said that if there were any cancellations
just thought I would update and let y’all know that I have an appointment with a doctor at Vanderbilt university medical in Franklin Tennessee in April. Vanderbilt is a RLS quality care center and the closest to me. I actually had one of their Doctors call me and said that if there were any cancellations
6236
in
Restless Legs Syndrome
3 months ago
red light therapy
has anyone ever heard of or tried red light therapy? I’m sure that’s not the proper medical term but that’s what Dr Cooper called it. After the nerve induction test he said both my legs showed nerve weakness and the red light therapy is what he prescribed saying that it might possibly help the RLS.
has anyone ever heard of or tried red light therapy? I’m sure that’s not the proper medical term but that’s what Dr Cooper called it. After the nerve induction test he said both my legs showed nerve weakness and the red light therapy is what he prescribed saying that it might possibly help the RLS.
6236
in
Restless Legs Syndrome
3 months ago
Secondary Cancers after CAR-T Cell Therapy
From New England Journal of Medicine dated 24th Jan 2024 (article is for subscribers only) This brief report states: [i]The demonstrated efficacy of the current generation of approved CAR-T products comes along with several well-described safety concerns, including risks of cytokine release syndrome
From New England Journal of Medicine dated 24th Jan 2024 (article is for subscribers only) This brief report states: [i]The demonstrated efficacy of the current generation of approved CAR-T products comes along with several well-described safety concerns, including risks of cytokine release syndrome
Jm954
Administrator
in
CLL Support
3 months ago
Red light/ near infrared light therapy
I have been treating my foot and legs with red light/ near infrared light with the Leanne Venier Red juvenator biophotonic led light matrix #3 formula lights over the past 3 months. My treatment was for multiple fractures of my foot bones and ligament and tendon sprains. Over the course of a month
I have been treating my foot and legs with red light/ near infrared light with the Leanne Venier Red juvenator biophotonic led light matrix #3 formula lights over the past 3 months. My treatment was for multiple fractures of my foot bones and ligament and tendon sprains. Over the course of a month
maxkat22
in
Restless Legs Syndrome
4 months ago
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