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Why does T3 lower T4?
Please could someone explain why taking Liothyronine when using T4/T3
combination
therapy
lowers T4? Does this always happen? Thanks for your help.
Please could someone explain why taking Liothyronine when using T4/T3
combination
therapy
lowers T4? Does this always happen? Thanks for your help.
Zebra5
in
Thyroid UK
Here we go again!
Another paper that raises the problem of unsuitable T4 treatment and the value of
combination
therapy
. It's behind a paywall, but the summary here I feel is very encouraging.
Combination
therapy
is becoming if not respectable at least worthy of examination. We definitely have progress here.
Another paper that raises the problem of unsuitable T4 treatment and the value of
combination
therapy
. It's behind a paywall, but the summary here I feel is very encouraging.
Combination
therapy
is becoming if not respectable at least worthy of examination. We definitely have progress here.
diogenes
in
Thyroid UK
arenaviral immunotherapies induce potent T cell responses in novel combinations and against tumor self-antigens
In this analysis, replicating arenaviral immunotherapy was sequentially combined with adoptively transferred TCR transgenic T cells, which resulted in tumor cures in all mice receiving
combination
therapy
, with 100 percent survival at the end of the experiment (60 days after administration)."
In this analysis, replicating arenaviral immunotherapy was sequentially combined with adoptively transferred TCR transgenic T cells, which resulted in tumor cures in all mice receiving
combination
therapy
, with 100 percent survival at the end of the experiment (60 days after administration)."
George71
in
Advanced Prostate Cancer
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Levothyroxine Monotherapy and Cancer
I have put a full description along with the evidence here: https://ibshypo.com/index.php/thyroxine-t4-and-cancer/ with an attempt to estimate the number of deaths resulting from monotherapy as compared to
combination
therapy
.
I have put a full description along with the evidence here: https://ibshypo.com/index.php/thyroxine-t4-and-cancer/ with an attempt to estimate the number of deaths resulting from monotherapy as compared to
combination
therapy
.
jimh111
in
Thyroid UK
Romixithub,Cybertine, BEAM then stem cell. Anyone had this combo
Anyone had this
combination
therapy
. Any info appreciated. Dave
Anyone had this
combination
therapy
. Any info appreciated. Dave
Doularg
in
Non Hodgkin's Lymphoma Friends
Eltroxin
I’m on T4/T3
combination
therapy
, and up until all of this drama I was actually doing pretty well. So I am now trying to find out info about alternative T4 medications such as eltroxin. Do NHS GP’s prescribe this? And can you source it privately? If so how much would it cost roughly? Many thanks:)
I’m on T4/T3
combination
therapy
, and up until all of this drama I was actually doing pretty well. So I am now trying to find out info about alternative T4 medications such as eltroxin. Do NHS GP’s prescribe this? And can you source it privately? If so how much would it cost roughly? Many thanks:)
Hafsah2345
in
Thyroid UK
Why test 6 - 8 weeks after dose change?
Also, is this stability dependent on therapy - eg. does T4 mono take the same length of time to stabilize as T3 mono or T4 / T3
combination
therapy
? Are there any studies to confirm this? Thanks!
Also, is this stability dependent on therapy - eg. does T4 mono take the same length of time to stabilize as T3 mono or T4 / T3
combination
therapy
? Are there any studies to confirm this? Thanks!
Evej13
in
Thyroid UK
Examining the need for T4/T3 combination therapy
Published online: September 30, 2021
DOI: https://doi.org/10.3803/EnM.2021.501
T4+T3
Therapy
: An Unsolved Problem of Increasing Magnitude and Complexity
Wilmar M. Wiersinga
Published online: September 30, 2021
DOI: https://doi.org/10.3803/EnM.2021.501
T4+T3
Therapy
: An Unsolved Problem of Increasing Magnitude and Complexity
Wilmar M. Wiersinga
diogenes
in
Thyroid UK
An upcoming book concerned with the correct treatment regime for thyroid replacement
Therapy
Therapy
diogenes
in
Thyroid UK
Another useful article showing minimal adverse effect dosing with T3 in addition to T4
T3 in
combination
gave better health signs when T4 only was given in
therapy
. T3 only therapy is still a step medicine won't yet tread, but at least
combination
therapy
is now seriously looked at
ORIGINAL RESEARCH article
Front.
T3 in
combination
gave better health signs when T4 only was given in
therapy
. T3 only therapy is still a step medicine won't yet tread, but at least
combination
therapy
is now seriously looked at
ORIGINAL RESEARCH article
Front.
diogenes
in
Thyroid UK
Combination T4/t3 therapy discussed
Future clinical trials using LT4 + T3 tablets better suited for
combination
therapy
will resolve the outstanding research questions relating to the place of LT4 + T3
combination
therapy
in the management of hypothyroidism.
Future clinical trials using LT4 + T3 tablets better suited for
combination
therapy
will resolve the outstanding research questions relating to the place of LT4 + T3
combination
therapy
in the management of hypothyroidism.
diogenes
in
Thyroid UK
Another study on T3 given to women with ongoing symptoms
Design Female hypothyroid patients with residual symptoms on LT4 monotherapy or
combination
LT4/LT3
therapy
received LT3 and LT4 monotherapy, respectively for 12 weeks in a non-blinded randomized crossover study. Methods Fifty-nine patients aged 18-65 years were included.
Design Female hypothyroid patients with residual symptoms on LT4 monotherapy or
combination
LT4/LT3
therapy
received LT3 and LT4 monotherapy, respectively for 12 weeks in a non-blinded randomized crossover study. Methods Fifty-nine patients aged 18-65 years were included.
diogenes
in
Thyroid UK
In vitro support for Simvastatin
Combination
therapy
with novel androgen receptor antagonists and statin for castration-resistant prostate cancer.
Combination
therapy
with novel androgen receptor antagonists and statin for castration-resistant prostate cancer.
cigafred
in
Advanced Prostate Cancer
Optimal Thyroid Hormone Replacement Jacqueline Jonklaas
The evidence shows that levothyroxine monotherapy carries much greater risk than
combination
therapy
. Doctors should practice evidence based medicine.
The evidence shows that levothyroxine monotherapy carries much greater risk than
combination
therapy
. Doctors should practice evidence based medicine.
jimh111
in
Thyroid UK
Glimpses of understanding
Given this discrepancy, it is important that any trial of
combination
therapy
be continued only as long as a patient benefit is being enjoyed. Monitoring for adverse effects, particularly in older or frail individuals, is necessary and
combination
therapy
should not be used during pregnancy.
Given this discrepancy, it is important that any trial of
combination
therapy
be continued only as long as a patient benefit is being enjoyed. Monitoring for adverse effects, particularly in older or frail individuals, is necessary and
combination
therapy
should not be used during pregnancy.
diogenes
in
Thyroid UK
The Swinging Pendulum in Treatment for Hypothyroidism: From (and Toward?) Combination Therapy
This was refreshing to see. I hope it does not take the average 15 years for this to be implemented in medical practice. https://www.frontiersin.org/articles/10.3389/fendo.2019.00446/full
This was refreshing to see. I hope it does not take the average 15 years for this to be implemented in medical practice. https://www.frontiersin.org/articles/10.3389/fendo.2019.00446/full
buddy99
in
Thyroid UK
Combination Therapy Rescues Neurons Suffering From Toxic Aggregates Of Alpha Synuclein In Cell Culture
In addition, impaired cells in cell culture were rescued by a
combination
therapy
of two drugs. One is an inexpensive blood pressure medicine. The other is a member of a family of toxic compounds being tried as cancer chemotherapy.
In addition, impaired cells in cell culture were rescued by a
combination
therapy
of two drugs. One is an inexpensive blood pressure medicine. The other is a member of a family of toxic compounds being tried as cancer chemotherapy.
park_bear
in
Cure Parkinson's
Autoimmune Thyroid Disorders in Autoimmune Addison´s Disease
Ninety-eight percent were treated with levothyroxine, 5% with
combination
therapy
with liothyronine or thyroid extracts, and 1% were observed without treatment.
Ninety-eight percent were treated with levothyroxine, 5% with
combination
therapy
with liothyronine or thyroid extracts, and 1% were observed without treatment.
helvella
Administrator
in
Thyroid UK
Another commentary on thyroid function treatment and combination therapy outcome
There seems to be an increasing awareness that something is wrong in diagnosing thyroid therapy sufficiency by TSH alone. This commentary is part of that discussion. However it still parrots the line that FT3 levels are unstable with T3 treatment, and that FT4 +TSH should remain the mainstay of treatment
There seems to be an increasing awareness that something is wrong in diagnosing thyroid therapy sufficiency by TSH alone. This commentary is part of that discussion. However it still parrots the line that FT3 levels are unstable with T3 treatment, and that FT4 +TSH should remain the mainstay of treatment
diogenes
in
Thyroid UK
A project to redefine treatment of hypothyroidism
[u]Design of a
therapy
trial specifically designed for those with unresolved symptoms [/u]
12. Understanding why patients prefer desiccated thyroid extract
over currently protocols used.
[u]Design of a
therapy
trial specifically designed for those with unresolved symptoms [/u]
12. Understanding why patients prefer desiccated thyroid extract
over currently protocols used.
diogenes
in
Thyroid UK
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