Experiences with

Combination therapy

It is pleasing to be able to state that my local NHS Endo has signed me up to Combination Therapy, to be managed at GP level, following a three month trial. Previously taking 200mcg T4 daily now to be taking 100mcg T4 plus 20mcg of T3 daily.

These findings highlight the potential of combination therapy to enhance immune response and extend survival, particularly in high-risk patients. https://prostatewarriors.com/2025/02/17/asco-gu-2025-combination-therapy-with-cabozantinib-and-atezolizumab-shows-promise-for-advanced-prostate-cancer/

A new research from Oslo University focuses on a new combination therapy for prostate cancer that uses a checkpoint inhibitor and an IRE1 blocker called MKC8866.

A multi-drug combination therapy including TH inhibitors should be further explored in clinical trials in PD patients.

Will I have to jump off the T3&4 combination therapy wagon and try to self source something else? Is Armour the answer? Grateful for any help.

This new combination therapy resulted in 43% of patients experiencing disease regression and showed increased survival rates. The study was conducted on 15 patients, and further research is needed to confirm the findings. The combination treatment was well-tolerated with no reported side effects.

[i]Early effects of LT3 + LT4 therapy on quality of life in hypothyroid patients: a randomized, double-blind, parallel-group comparison trial.

Hi, When on combination therapy does the amount of T3 you take impact the conversion of T4 to T3? For example, if you was on 75mcg T4 and 20T3 would the conversion of the T4 be worse if you increased the T3 to 30mcg of more?

APVO442 also has potential for use in combination therapy with other cancer treatments. https://prostatewarriors.com/2024/12/05/apvo442-a-promising-new-bispecific-antibody-for-prostate-cancer-treatment/

[/i] [i]L-T4, L-T3, DTE, Hypothyroidism, Patient preference, Combination therapy[/i] Behind a paywall - as so often: https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgae651/7759898

Should T4 still be within range when on combination therapy? Does it sound right that I should be on the same dose of Levo now during combination therapy as I was before adding in T3? No meds taken before early blood draw.

This combination therapy is being compared to the use of abiraterone acetate and prednisone alone in patients with specific genetic mutations related to DNA repair.

I was diagnosed with hypothyroidism about 25 years ago, in my mid-thirties. For almost 20 years, I took only Levothyroxine. I realise now that I was probably depressed for the whole period. Back in 2016, I decided to quit drinking alcohol. I wasn't an alcoholic, but I was drinking every day, and sometimes

https://www.sciencedirect.com/science/article/pii/S0302283824022644 in a nutshell: 1 - Deep and Durable PSA Response: The combination therapy produced a significant number of patients achieving undetectable PSA levels (<0.2 ng/ml).

The combination therapy failed to demonstrate significant antitumor activity. Only one patient achieved a maximum PSA decline of 14% from baseline. The median rPFS was 3.7 months, and the median OS was 9.6 months.

Is there data/medical papers I can give my doctor as to why T3 is suppressed on combination therapy? I have tried looking at the Nice guidelines but they all seem against using combination therapy.Thanks Sue

Just seen endo (well endo's registrar actually) and started on T3/T4 combination therapy.

I am now (after a very long time) prescribed T3 on the NHS and am on T4/T3 combination therapy. This was because I was on an over-range dose of T4 to get sufficient T3/was not converting. I take 100mcg Teva T4 per day in the morning; 2.5mcg T3 Morningside three times a day (so 7.5mcg per day).

Unfortunately, my (sharp young bright female) Endo who understood that a low TSH is normal with combination therapy has moved away. I have been given to new young male Endo who has glowing patient reviews.

therapy for MPN."