Experiences with

Combination therapy

Please could someone explain why taking Liothyronine when using T4/T3 combination therapy lowers T4? Does this always happen? Thanks for your help.

Another paper that raises the problem of unsuitable T4 treatment and the value of combination therapy. It's behind a paywall, but the summary here I feel is very encouraging. Combination therapy is becoming if not respectable at least worthy of examination. We definitely have progress here.

In this analysis, replicating arenaviral immunotherapy was sequentially combined with adoptively transferred TCR transgenic T cells, which resulted in tumor cures in all mice receiving combination therapy, with 100 percent survival at the end of the experiment (60 days after administration)."

I have put a full description along with the evidence here: https://ibshypo.com/index.php/thyroxine-t4-and-cancer/ with an attempt to estimate the number of deaths resulting from monotherapy as compared to combination therapy.

Anyone had this combination therapy. Any info appreciated. Dave

I’m on T4/T3 combination therapy, and up until all of this drama I was actually doing pretty well. So I am now trying to find out info about alternative T4 medications such as eltroxin. Do NHS GP’s prescribe this? And can you source it privately? If so how much would it cost roughly? Many thanks:)

Also, is this stability dependent on therapy - eg. does T4 mono take the same length of time to stabilize as T3 mono or T4 / T3 combination therapy? Are there any studies to confirm this? Thanks!

Published online: September 30, 2021 DOI: https://doi.org/10.3803/EnM.2021.501 T4+T3 Therapy: An Unsolved Problem of Increasing Magnitude and Complexity Wilmar M. Wiersinga

T3 in combination gave better health signs when T4 only was given in therapy. T3 only therapy is still a step medicine won't yet tread, but at least combination therapy is now seriously looked at ORIGINAL RESEARCH article Front.

Future clinical trials using LT4 + T3 tablets better suited for combination therapy will resolve the outstanding research questions relating to the place of LT4 + T3 combination therapy in the management of hypothyroidism.

Design Female hypothyroid patients with residual symptoms on LT4 monotherapy or combination LT4/LT3 therapy received LT3 and LT4 monotherapy, respectively for 12 weeks in a non-blinded randomized crossover study. Methods Fifty-nine patients aged 18-65 years were included.

Combination therapy with novel androgen receptor antagonists and statin for castration-resistant prostate cancer.

The evidence shows that levothyroxine monotherapy carries much greater risk than combination therapy. Doctors should practice evidence based medicine.

Given this discrepancy, it is important that any trial of combination therapy be continued only as long as a patient benefit is being enjoyed. Monitoring for adverse effects, particularly in older or frail individuals, is necessary and combination therapy should not be used during pregnancy.

This was refreshing to see. I hope it does not take the average 15 years for this to be implemented in medical practice. https://www.frontiersin.org/articles/10.3389/fendo.2019.00446/full

In addition, impaired cells in cell culture were rescued by a combination therapy of two drugs. One is an inexpensive blood pressure medicine. The other is a member of a family of toxic compounds being tried as cancer chemotherapy.

Ninety-eight percent were treated with levothyroxine, 5% with combination therapy with liothyronine or thyroid extracts, and 1% were observed without treatment.

There seems to be an increasing awareness that something is wrong in diagnosing thyroid therapy sufficiency by TSH alone. This commentary is part of that discussion. However it still parrots the line that FT3 levels are unstable with T3 treatment, and that FT4 +TSH should remain the mainstay of treatment

[u]Design of a therapy trial specifically designed for those with unresolved symptoms
[/u] 12. Understanding why patients prefer desiccated thyroid extract over currently protocols used.