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Initial Phase 1 Data on MB-105 for Patients with PSCA-positive Castration Resistant Prostate Cancer
From what I understand PSCA is highly expressed in prostate cancer cells but also in other kinds of cancer and also in other tissues (in small amounts), and its production increases as the disease progresses, making it a better target for later stages (but this is my speculation!). What is important
From what I understand PSCA is highly expressed in prostate cancer cells but also in other kinds of cancer and also in other tissues (in small amounts), and its production increases as the disease progresses, making it a better target for later stages (but this is my speculation!). What is important
Maxone73
in
Advanced Prostate Cancer
5 months ago
Eligard
My PSA keep rising. Today, PSA went up to 2.25.1 from 1.1 (March). Doctor told me that he never had a patient Eligard does not work at all at the beginning. He asked me to go thru with PSMA scan and start to take Xtandi. He said there is a possibility I may also go thru with a testicle removal surgery
My PSA keep rising. Today, PSA went up to 2.25.1 from 1.1 (March). Doctor told me that he never had a patient Eligard does not work at all at the beginning. He asked me to go thru with PSMA scan and start to take Xtandi. He said there is a possibility I may also go thru with a testicle removal surgery
Domas
in
Advanced Prostate Cancer
5 months ago
European Medicines Agency approves Phase II trial of uTRACE in prostate cancer: good news because they also have uTREAT
While uTRACE is a diagnostic tool, its brother uTREAT will be a very interesting radioligand for drug delivery in the near future (like Actinium, Lutetium & Co) uTRACE is used as a PET-tracer ligand that targets the uPAR receptor, which is known to be a biomarker for cancer aggressiveness. https:
While uTRACE is a diagnostic tool, its brother uTREAT will be a very interesting radioligand for drug delivery in the near future (like Actinium, Lutetium & Co) uTRACE is used as a PET-tracer ligand that targets the uPAR receptor, which is known to be a biomarker for cancer aggressiveness. https:
Maxone73
in
Advanced Prostate Cancer
5 months ago
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Dad with Advanced PCA :(
Hi everyone, I am new here and appreciate any assistance that could help my father. My dad is 73 years of age. Over the last few weeks we have gone from a raised PSA level 8.9 (up from 6 in 2022 and 2021, 5.1 in 2020), Negative DRE, to an MRI (PIRADS 5, SAG T2) to a positive biopsy (10 cores taken,
Hi everyone, I am new here and appreciate any assistance that could help my father. My dad is 73 years of age. Over the last few weeks we have gone from a raised PSA level 8.9 (up from 6 in 2022 and 2021, 5.1 in 2020), Negative DRE, to an MRI (PIRADS 5, SAG T2) to a positive biopsy (10 cores taken,
MissMel2024
in
Advanced Prostate Cancer
5 months ago
Enlarged Lymph Nodes on MRI and CT
Hello, new to this. Never posted before, hoping for some insight. Gleason 7 (4+3) PSA 6. Bone scan clear but lymphadenopathy in groin nodes (inguinal; iliac nodes). Does this mean spread? Being sent for a PET Scan Friday.
Hello, new to this. Never posted before, hoping for some insight. Gleason 7 (4+3) PSA 6. Bone scan clear but lymphadenopathy in groin nodes (inguinal; iliac nodes). Does this mean spread? Being sent for a PET Scan Friday.
Blue1320
in
Prostate Cancer Network
5 months ago
Tripple therapy - ADT+Lynparza+Xtandi
I just started Lynparza in addition to Xtandi and Loupron. I don’t have a BRCA mutation, but I was told that Lynparza may be beneficial regardless. I finished cycle of Jevtana (7 infusions) and Xtandi. My PSA was 0.74, but now it has increased to 2.3. All other tretments and history are in my bio. The
I just started Lynparza in addition to Xtandi and Loupron. I don’t have a BRCA mutation, but I was told that Lynparza may be beneficial regardless. I finished cycle of Jevtana (7 infusions) and Xtandi. My PSA was 0.74, but now it has increased to 2.3. All other tretments and history are in my bio. The
venecia1983
in
Advanced Prostate Cancer
5 months ago
Please join INHERIT Study
Join the INHERIT Study to help us better understand the genetic risk for lung cancer, and what can be done for prevention and treatment. Our goals are to learn more about: -Inherited or genetic risk for developing lung cancer in certain people or families -Changes in lung cancer tumors in people with
Join the INHERIT Study to help us better understand the genetic risk for lung cancer, and what can be done for prevention and treatment. Our goals are to learn more about: -Inherited or genetic risk for developing lung cancer in certain people or families -Changes in lung cancer tumors in people with
Miranda_GO2
Partner
in
Lung Cancer Support
5 months ago
EMBARK Trial: Combination-therapy is better.
This chart compares the risk of developing metastasis from prostate cancer, after 5 years from curative treatment, between three different arms of the EMBARK study (published in 2023): (1) Lupron monotherapy; (2) Enzalutamide monotherapy; and (3) Enzalutamide + Lupron combination therapy. The cohort
This chart compares the risk of developing metastasis from prostate cancer, after 5 years from curative treatment, between three different arms of the EMBARK study (published in 2023): (1) Lupron monotherapy; (2) Enzalutamide monotherapy; and (3) Enzalutamide + Lupron combination therapy. The cohort
janebob99
in
Prostate Cancer Network
5 months ago
3 Abiraterone tabs in place of 4.
Warriors Some time back I posted that my MO had told me to take 3 Abiraterone tablets with 5 mg Prednisone daily instead of 4 to help with an out of control Blood Pressure problem. I was worried (as were some of the responses) that this could impact the ADT therapy. Recently had blood work done
Warriors Some time back I posted that my MO had told me to take 3 Abiraterone tablets with 5 mg Prednisone daily instead of 4 to help with an out of control Blood Pressure problem. I was worried (as were some of the responses) that this could impact the ADT therapy. Recently had blood work done
85236442968
in
Advanced Prostate Cancer
5 months ago
Ketogenic diet alters the epigenetic and immune landscape of prostate cancer to overcome resistance to immune checkpoint blockade therapy.
Overall, this strikes me as too hypothetical for us to apply, but what do I know? "Overall, these findings illuminate a potential clinical path of using HDACi and optimized KD regimens to enhance ICB therapy for PCa." HDACi = histone deacetylase inhibitor [To date, four HDAC inhibitors, Vorinostat
Overall, this strikes me as too hypothetical for us to apply, but what do I know? "Overall, these findings illuminate a potential clinical path of using HDACi and optimized KD regimens to enhance ICB therapy for PCa." HDACi = histone deacetylase inhibitor [To date, four HDAC inhibitors, Vorinostat
cigafred
in
Fight Prostate Cancer
5 months ago
Only mouse study, but interesting research on microbiome using astragaloside and scorpion venom
Astragaloside IV-PESV inhibits prostate cancer tumor growth by restoring gut microbiota and microbial metabolic homeostasis via the AGE-RAGE pathwayXujun You, Junfeng Qiu, Qixin Li, Qing Zhang, Wen Sheng, Yiguo Cao, Wei Fu BMC cancer 24 (1), 472, 2024 Background Prostate cancer (PCa) is becoming the
Astragaloside IV-PESV inhibits prostate cancer tumor growth by restoring gut microbiota and microbial metabolic homeostasis via the AGE-RAGE pathwayXujun You, Junfeng Qiu, Qixin Li, Qing Zhang, Wen Sheng, Yiguo Cao, Wei Fu BMC cancer 24 (1), 472, 2024 Background Prostate cancer (PCa) is becoming the
Graham49
in
Advanced Prostate Cancer
3 months ago
Any adverse effect if taking three-month Lupron shot two weeks late?
Hi friends, my father has been on Lupron shots every three months with Abiraterone pills for about a year now. His next shot will be 14 weeks due to some insurance problems. What is the ideal and acceptable time range between shots that won’t risks benefits of treatment? What is the out of pocket price
Hi friends, my father has been on Lupron shots every three months with Abiraterone pills for about a year now. His next shot will be 14 weeks due to some insurance problems. What is the ideal and acceptable time range between shots that won’t risks benefits of treatment? What is the out of pocket price
qidao23
in
Advanced Prostate Cancer
5 months ago
If PSA is Suppressed by Doublet ADT, Will Salvage IMRT Cause a PSA Rise?
Hello everyone, My husband is nearing completion of his extended pelvic salvage IMRT with boost to retrocaval lymph nodes. His radiation oncologist said it may take several months before the psa calms down, so he would like to see him in July. My question is that, since he is already undetectable due
Hello everyone, My husband is nearing completion of his extended pelvic salvage IMRT with boost to retrocaval lymph nodes. His radiation oncologist said it may take several months before the psa calms down, so he would like to see him in July. My question is that, since he is already undetectable due
103532
in
Advanced Prostate Cancer
5 months ago
HDR Brachytherapy after initial RT
Anyone has a success story to share on using HDR Brachytherapy 2-3 years after initial Radiation of the prostate gland in case of recurrence of cancer? Thank you for sharing your story.
Anyone has a success story to share on using HDR Brachytherapy 2-3 years after initial Radiation of the prostate gland in case of recurrence of cancer? Thank you for sharing your story.
Simonapo
in
Advanced Prostate Cancer
5 months ago
Timing of Docetaxel
Hello. Am now in year 10. Details in profile. For 2+ years have been taking Zoladex, Zytiga and Prednisolone. The CT bone scans and Nuclear medicine full body scans every 6 months show no radiographic progression and I feel ok, apart from fatigue when not active. Recently have some discomfort
Hello. Am now in year 10. Details in profile. For 2+ years have been taking Zoladex, Zytiga and Prednisolone. The CT bone scans and Nuclear medicine full body scans every 6 months show no radiographic progression and I feel ok, apart from fatigue when not active. Recently have some discomfort
Ian99
in
Advanced Prostate Cancer
5 months ago
10-year update still shows no benefit to ART vs early SRT
ART
= adjuvant radiation therapy, within 6 months after radical prostatectomy (RP)
early SRT
= salvage radiation therapy, after PSA ≥ 0.1ng/ml or 3 consecutive rises. Median was 0.2 ng/ml. Median 1 ½ years after RP. Patients risked nothing by waiting, and gained urinary and fecal continence
ART
= adjuvant radiation therapy, within 6 months after radical prostatectomy (RP)
early SRT
= salvage radiation therapy, after PSA ≥ 0.1ng/ml or 3 consecutive rises. Median was 0.2 ng/ml. Median 1 ½ years after RP. Patients risked nothing by waiting, and gained urinary and fecal continence
Tall_Allen
in
Advanced Prostate Cancer
5 months ago
Docetaxel Failing
Greetings from Inverness in the beautiful Highlands of Scotland! I would like to share my journey with you and hopefully get some advice on future treatments. In December 2022 following diagnoses of advanced prostate cancer with multiple bone metastasis I started zytiga + prednisone and 6 monthly triptorelin
Greetings from Inverness in the beautiful Highlands of Scotland! I would like to share my journey with you and hopefully get some advice on future treatments. In December 2022 following diagnoses of advanced prostate cancer with multiple bone metastasis I started zytiga + prednisone and 6 monthly triptorelin
Fisherman2
in
Advanced Prostate Cancer
5 months ago
BILLY NEEDS HELP
OK troops, after 26 years of surviving post prostectomy, with a Gleason 4/3, 4/4, some 41 rounds of intermittent hormone therapy using lupron, casadex, advodart, I had a break thru last November as my psa went back up mid on cycle. After having my radiation oncologist ignore the realities of this, I
OK troops, after 26 years of surviving post prostectomy, with a Gleason 4/3, 4/4, some 41 rounds of intermittent hormone therapy using lupron, casadex, advodart, I had a break thru last November as my psa went back up mid on cycle. After having my radiation oncologist ignore the realities of this, I
billyboy3
in
Advanced Prostate Cancer
5 months ago
how much to raise by?
I’m taking tamoxifen for breast cancer. It had impacted thyroid levels in the autumn but I only adjusted by a little. Latest test was tsh 5.17 and t4 17 (not taken that day) on 125 for 3 days a week and 100 for 4 days a week. Obviously I’m not very with it now. I think it has been like this for
I’m taking tamoxifen for breast cancer. It had impacted thyroid levels in the autumn but I only adjusted by a little. Latest test was tsh 5.17 and t4 17 (not taken that day) on 125 for 3 days a week and 100 for 4 days a week. Obviously I’m not very with it now. I think it has been like this for
haggisplant
in
Thyroid UK
5 months ago
Which supplements are members using for advanced prostate? I take curcumin and others. I want to know more.
I am diagnosed stage 4 adeno carcinoma of prostate. Receiving Erleada and injections of Leuprolide. I want to supplement with everything known to fight this thing. Who has a list?
I am diagnosed stage 4 adeno carcinoma of prostate. Receiving Erleada and injections of Leuprolide. I want to supplement with everything known to fight this thing. Who has a list?
Cebubob
in
Advanced Prostate Cancer
3 months ago
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