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PSA doubled in last 30 days after 4 months stable since Provenge. What's next?
Update: PSA remained roughly 1.7 to 1.8 for last 4 months after Provenge but yesterday's 30-day PSA test revealed a jump to 3.190 so something is growing quick. I have been off of all ADT since finishing fourth LU-177 injection five months ago and one SBRT treatment 4 months ago. After LU-177, PSA
Update: PSA remained roughly 1.7 to 1.8 for last 4 months after Provenge but yesterday's 30-day PSA test revealed a jump to 3.190 so something is growing quick. I have been off of all ADT since finishing fourth LU-177 injection five months ago and one SBRT treatment 4 months ago. After LU-177, PSA
SViking
in
Advanced Prostate Cancer
6 months ago
my first post
Hello there, I’ve been dealing with this since 1/2015. I’ve had brachytherapy, chemotherapy, hormone therapy, cyber knife, immunotherapy, more chemotherapy, now taking Everolimus and letrozole. I’ve always felt that this was a chronic disease after the medications stopped working onto the next regimen
Hello there, I’ve been dealing with this since 1/2015. I’ve had brachytherapy, chemotherapy, hormone therapy, cyber knife, immunotherapy, more chemotherapy, now taking Everolimus and letrozole. I’ve always felt that this was a chronic disease after the medications stopped working onto the next regimen
Sabrina02
in
SHARE Uterine Cancer Support
6 months ago
PSA vs Testosterone Nadir for CRPC and Non-CRPC
This plot from Safriadi (2022) compares the mean values of PSA nadir versus Testosterone Nadir comparing Non-Castrate Resistant PC (Non-CRPC) to Castrate-Resistant PC (CRPC) men. For Non-CRPC men, the range of T-nadir was 2.5-49 ng/dL (mean = 21) and range for PSA nadir was 0.02-9 ng/mL (mean=2). For
This plot from Safriadi (2022) compares the mean values of PSA nadir versus Testosterone Nadir comparing Non-Castrate Resistant PC (Non-CRPC) to Castrate-Resistant PC (CRPC) men. For Non-CRPC men, the range of T-nadir was 2.5-49 ng/dL (mean = 21) and range for PSA nadir was 0.02-9 ng/mL (mean=2). For
janebob99
in
Advanced Prostate Cancer
6 months ago
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Can anyone help me please.....
Hi, can anyone help me with these test results please.I have Graves disease, Anemia, pernicious anemia, vitamin D deficiency and various other ailments, but I have been in remission from my graves for at least 5 years. I have been symptomatic a few times but it seems to correct itself, however my hubby
Hi, can anyone help me with these test results please.I have Graves disease, Anemia, pernicious anemia, vitamin D deficiency and various other ailments, but I have been in remission from my graves for at least 5 years. I have been symptomatic a few times but it seems to correct itself, however my hubby
Loza73
in
Thyroid UK
6 months ago
Help for a newbie at start of journey
Hi there. Just joined the forum and its a fantastic source of information - thank you. Was just diagnosed with hypothyroid a week ago after 4 years of feeling totally wiped out so trying to get to grips with it all and can see from the forum its a bit of a journey to try to get well again. Would appreciate
Hi there. Just joined the forum and its a fantastic source of information - thank you. Was just diagnosed with hypothyroid a week ago after 4 years of feeling totally wiped out so trying to get to grips with it all and can see from the forum its a bit of a journey to try to get well again. Would appreciate
Irish_Gal
in
Thyroid UK
6 months ago
Rising PSA post RP,IRT,ADT
Have 2 consecutive rising PSA - .04,.05,.1. Year post RP,IRT,ADT.. understand if goes to .2 new scans and possible Radiation. I surely don't like the ADT.. Any thoghts
Have 2 consecutive rising PSA - .04,.05,.1. Year post RP,IRT,ADT.. understand if goes to .2 new scans and possible Radiation. I surely don't like the ADT.. Any thoghts
ChristopherH
in
Advanced Prostate Cancer
6 months ago
Thyroid medication changes when starting HRT for perimenopause
I have been self medicating with liothyronine and levothyroxine for the past two years or so. Today I started the estrogen patch for perimenopause symptoms, and will also start progesterone in a couple of days. The provider that prescribed these said that some women need to increase their thyroid
I have been self medicating with liothyronine and levothyroxine for the past two years or so. Today I started the estrogen patch for perimenopause symptoms, and will also start progesterone in a couple of days. The provider that prescribed these said that some women need to increase their thyroid
TurtlesAllTheWay
in
Thyroid UK
6 months ago
At the crossroads (again)
My profile is up to date, but, briefly, have failed chemo, ADT (am castrate resistant), failed Keytruda and now Pluvicto. Scans yest. & today show progression along with PSA rise. All my mets are in bone. So, my SOC choices are cabazataxel or radium 223. Other options are trial, which are a crapshoot
My profile is up to date, but, briefly, have failed chemo, ADT (am castrate resistant), failed Keytruda and now Pluvicto. Scans yest. & today show progression along with PSA rise. All my mets are in bone. So, my SOC choices are cabazataxel or radium 223. Other options are trial, which are a crapshoot
rsgdmd
in
Advanced Prostate Cancer
6 months ago
Is This Normal??
Is it normal after nearly 5 years on ADT + Zytig, Prednisone, and Xgeva, to have constant "Flu-Like" symptoms, (sans a fever)? Some days, everything hurts, legs hurt at night , feel like my blood is boiling while I try to sleep. Are these "side effects" or just part of the advanced cancer? Excruciating
Is it normal after nearly 5 years on ADT + Zytig, Prednisone, and Xgeva, to have constant "Flu-Like" symptoms, (sans a fever)? Some days, everything hurts, legs hurt at night , feel like my blood is boiling while I try to sleep. Are these "side effects" or just part of the advanced cancer? Excruciating
TommyCarz2
in
Advanced Prostate Cancer
6 months ago
Patches (I'm depending on you, son)
Dated pop reference - sorry. While my research has continued, my oncologist has nothing to give me within the SOC to keep the PSA in check. Now I've witnessed another unwelcome visitor: facial hair (it only took me 70 yrs to start shaving....) Joking aside however, that means the T is on the rise.
Dated pop reference - sorry. While my research has continued, my oncologist has nothing to give me within the SOC to keep the PSA in check. Now I've witnessed another unwelcome visitor: facial hair (it only took me 70 yrs to start shaving....) Joking aside however, that means the T is on the rise.
CrocodileShoes
in
Advanced Prostate Cancer
6 months ago
Gynecomastia from ADT - how much?
Gynecomastia from ADT - how much? I am considering asking my oncologist for transdermal estrogn (TDE) therapy instead of Orgovyx to combat my prostate cancer. Since gynecomastia and breast pain are pretty much the only bad side effects from TDE and less troubling to me than metabolic disturbance,
Gynecomastia from ADT - how much? I am considering asking my oncologist for transdermal estrogn (TDE) therapy instead of Orgovyx to combat my prostate cancer. Since gynecomastia and breast pain are pretty much the only bad side effects from TDE and less troubling to me than metabolic disturbance,
Lost_Sheep
in
Prostate Cancer Network
6 months ago
DENOSUNAB
I have stage 4 incurable lung cancerI have been on this drug for 20 months in respect of my bone cancer. My scans to date have all been stable and continue to show that the cancer has shrunk or disappeared to date. However, as my targeted therapy treatment (Brigatinib) is working, I am enquiring whether
I have stage 4 incurable lung cancerI have been on this drug for 20 months in respect of my bone cancer. My scans to date have all been stable and continue to show that the cancer has shrunk or disappeared to date. However, as my targeted therapy treatment (Brigatinib) is working, I am enquiring whether
Gymbuddie
in
The Roy Castle Lung Cancer Foundation
10 months ago
Help and Advice
I have been suffering some time now ( years perhaps ) with debilitating symptoms such as exhaustion, puffy face, coldness, constipation, dry skin, hair shedding, muscle aches and more recently severe numbness and pins and needles in my hands. I thought this may be the onset on menopause as I am now
I have been suffering some time now ( years perhaps ) with debilitating symptoms such as exhaustion, puffy face, coldness, constipation, dry skin, hair shedding, muscle aches and more recently severe numbness and pins and needles in my hands. I thought this may be the onset on menopause as I am now
Sarageorge1971
in
Thyroid UK
6 months ago
OS versus Testosterone Nadir - 5
This plot shows the Overall Survival Probability after RT and ADT, for Advance Prostate Cancer men, comparing two different ranges of testosterone nadir (< 10 ng/dL, and 10-20 ng/dL) after 11 years. The
best
outcomes
are significantly associated with a
lower testosterone nadir ( <
This plot shows the Overall Survival Probability after RT and ADT, for Advance Prostate Cancer men, comparing two different ranges of testosterone nadir (< 10 ng/dL, and 10-20 ng/dL) after 11 years. The
best
outcomes
are significantly associated with a
lower testosterone nadir ( <
janebob99
in
Advanced Prostate Cancer
6 months ago
OS versus Testosterone Nadir - 4
This plot shows the Overall Survival Probability after RT and ADT, for Advance Prostate Cancer men, comparing different levels of testosterone nadir (< 10 ng/dL, 10-20, and 20-50, The
best
outcomes
are significantly associated with a
lower testosterone nadir ( < 10 ng/dL).
[b
This plot shows the Overall Survival Probability after RT and ADT, for Advance Prostate Cancer men, comparing different levels of testosterone nadir (< 10 ng/dL, 10-20, and 20-50, The
best
outcomes
are significantly associated with a
lower testosterone nadir ( < 10 ng/dL).
[b
janebob99
in
Advanced Prostate Cancer
6 months ago
PSA relapse rate vs testosterone nadir - 3
This plot shows the PSA relapse rate after RT and ADT, for Intermediate and High Risk men, comparing different levels of testosterone nadir ( 50 nd/dL). (ref: 2019) The
best
outcomes
are significantly associated with a
lower testosterone nadir ( < 20 ng/dL),
and the relationship
This plot shows the PSA relapse rate after RT and ADT, for Intermediate and High Risk men, comparing different levels of testosterone nadir ( 50 nd/dL). (ref: 2019) The
best
outcomes
are significantly associated with a
lower testosterone nadir ( < 20 ng/dL),
and the relationship
janebob99
in
Advanced Prostate Cancer
6 months ago
PSA Survival vs Testosterone Nadir - 2
This plot shows the Biochemical Relapse Free Survival after RT and ADT, after 10 years , for Intermediate and High Risk men, comparing different levels of testosterone nadir ( 50 nd/dL). (ref: 2019) The
best
outcomes
are significantly associated with a
lower testosterone nadir ( < 20
This plot shows the Biochemical Relapse Free Survival after RT and ADT, after 10 years , for Intermediate and High Risk men, comparing different levels of testosterone nadir ( 50 nd/dL). (ref: 2019) The
best
outcomes
are significantly associated with a
lower testosterone nadir ( < 20
janebob99
in
Advanced Prostate Cancer
6 months ago
PSA Survival vs Testosterone Nadir - 1
This plot shows the Biochemical Relapse Free Survival after RT and ADT, versus time for up to 18 years, for Intermediate and High Risk men, comparing different levels of testosterone nadir ( 50 nd/dL). (ref: 2019) The
best
outcomes
are significantly associated with a
lower testosterone
This plot shows the Biochemical Relapse Free Survival after RT and ADT, versus time for up to 18 years, for Intermediate and High Risk men, comparing different levels of testosterone nadir ( 50 nd/dL). (ref: 2019) The
best
outcomes
are significantly associated with a
lower testosterone
janebob99
in
Advanced Prostate Cancer
6 months ago
Fed up at not being able to do basic stuff
Over last 2 years health wise gonw bad to worse. No energy little interest i. Going out or even getting dressed.I used to be very i dependent ie own diy. Cleani g shoppi g ect. Even had craft hobby.but now all i seemto want to do is sleep
Over last 2 years health wise gonw bad to worse. No energy little interest i. Going out or even getting dressed.I used to be very i dependent ie own diy. Cleani g shoppi g ect. Even had craft hobby.but now all i seemto want to do is sleep
lizaspo
in
British Liver Trust
8 months ago
Are we on the right track?
Hi All, My husband, Pat (61) was diagnosed in late February with low grade metastatic PC. Gleason 9 grade 5. PSA 32. In a few small pelvic lymph nodes and a couple pelvic lesions. No other spread. PSMA pet scan detected this. We are working with a team and when we were told his diagnosis from his
Hi All, My husband, Pat (61) was diagnosed in late February with low grade metastatic PC. Gleason 9 grade 5. PSA 32. In a few small pelvic lymph nodes and a couple pelvic lesions. No other spread. PSMA pet scan detected this. We are working with a team and when we were told his diagnosis from his
Kathyford
in
Advanced Prostate Cancer
3 months ago
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