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Castration
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New articles from the NIH
A randomised, double-blind, dose-finding, phase II multicentre study of ODX in the treatment of patients with
castration
-resistant prostate cancer and skeletal metastases.
A randomised, double-blind, dose-finding, phase II multicentre study of ODX in the treatment of patients with
castration
-resistant prostate cancer and skeletal metastases.
Magnus1964
in
Prostate Cancer Network
2 years ago
New NIH articles on prostate cancer
A randomised, double-blind, dose-finding, phase II multicentre study of ODX in the treatment of patients with
castration
-resistant prostate cancer and skeletal metastases.
A randomised, double-blind, dose-finding, phase II multicentre study of ODX in the treatment of patients with
castration
-resistant prostate cancer and skeletal metastases.
Magnus1964
in
Advanced Prostate Cancer
2 years ago
Opinions on Lu-PSMA-617 Clinical Trial
Hello all, my father’s oncologist has suggested we start looking into clinical trials or chemotherapy now for his metastatic
castration
resistant prostate cancer (metastasized to the coccyx/pelvic bone in 2019). The trial the oncologist suggested is in the title.
Hello all, my father’s oncologist has suggested we start looking into clinical trials or chemotherapy now for his metastatic
castration
resistant prostate cancer (metastasized to the coccyx/pelvic bone in 2019). The trial the oncologist suggested is in the title.
PHnerd
in
Advanced Prostate Cancer
2 years ago
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Advanced PC with a 90 years old
When he becomes
castration
resistant in the future, I'm afraid he won't have many options because of his age and health condition. With
castration
resistance, is ADT and another AR inhibitor or CYP17 inhibitor still a treatment option for him?
When he becomes
castration
resistant in the future, I'm afraid he won't have many options because of his age and health condition. With
castration
resistance, is ADT and another AR inhibitor or CYP17 inhibitor still a treatment option for him?
TN1932
in
Advanced Prostate Cancer
2 years ago
Robust PSA Drops With Radionuclide Therapy in CRPCa— All but one patient had a PSA decline after a fractionated dose of 225Ac-J591
During his discussion, Scher said the case report "changed the metrics for patients with metastatic
castration
-resistant prostate cancer. There is no systemic therapy that has been shown to do this.
During his discussion, Scher said the case report "changed the metrics for patients with metastatic
castration
-resistant prostate cancer. There is no systemic therapy that has been shown to do this.
cujoe
in
Fight Prostate Cancer
1 year ago
Long Term Zoloft/Sertraline, or other SSRI Treatment, might increase Coronary Artery Atherosclerosis and stroke risk
Nowadays, I fight mild depression (caused by cancer and
castration
meds) by exercising, listening to music I love, on good headphones, and drinking Jade Leaf Matcha green tea powder. I feel happiest after jogging with the headphone music playing.
Nowadays, I fight mild depression (caused by cancer and
castration
meds) by exercising, listening to music I love, on good headphones, and drinking Jade Leaf Matcha green tea powder. I feel happiest after jogging with the headphone music playing.
GeorgeGlass
in
Advanced Prostate Cancer
2 years ago
Would like help in treatment options.
I didn't fully realize until a visit with my urologist for a bladder cancer clean up that the
castration
sensitivity ends at some point for every one. I have been riding along thinking I could stay sensitive for years.
I didn't fully realize until a visit with my urologist for a bladder cancer clean up that the
castration
sensitivity ends at some point for every one. I have been riding along thinking I could stay sensitive for years.
agyoung
in
Advanced Prostate Cancer
2 years ago
Xtandi and Talzenna
From Urotoday.com: "Pfizer Inc. announced positive topline results from the Phase 3 TALAPRO-2 study of TALZENNA® (talazoparib), an oral poly ADP-ribose polymerase (PARP) inhibitor, in combination with XTANDI® (enzalutamide) compared to placebo plus XTANDI in men with metastatic
castration
-resistant prostate
From Urotoday.com: "Pfizer Inc. announced positive topline results from the Phase 3 TALAPRO-2 study of TALZENNA® (talazoparib), an oral poly ADP-ribose polymerase (PARP) inhibitor, in combination with XTANDI® (enzalutamide) compared to placebo plus XTANDI in men with metastatic
castration
-resistant prostate
Bjry
in
Advanced Prostate Cancer
2 years ago
Rezvilutamide: new anti-androgen is better than Casodex added to ADT for newly diagnosed high-met HSPC. But is field too crowded?
It also significantly increased time to
castration
resistance by 79%. Like Nubeqa, Rezvilutamide doesn't appreciably penetrate the blood-brain barrier. There weren't any large differences in side effects.
It also significantly increased time to
castration
resistance by 79%. Like Nubeqa, Rezvilutamide doesn't appreciably penetrate the blood-brain barrier. There weren't any large differences in side effects.
Tall_Allen
in
Advanced Prostate Cancer
2 years ago
Roche Abandons AKT Prostate Cancer Asset
Another one bites the dust ☹️ Roche Abandons AKT Prostate Cancer Asset Published: Feb 02, 2023 By Tristan Manalac Courtesy Smith Collection/Gado/Getty Images Roche is dropping its investigational AKT inhibitor ipatasertib, which was being assessed in a Phase III trial for
castration
-resistant
Another one bites the dust ☹️ Roche Abandons AKT Prostate Cancer Asset Published: Feb 02, 2023 By Tristan Manalac Courtesy Smith Collection/Gado/Getty Images Roche is dropping its investigational AKT inhibitor ipatasertib, which was being assessed in a Phase III trial for
castration
-resistant
Scout4answers
in
Advanced Prostate Cancer
2 years ago
Absolutely furious!
I did not add I am qualified in
castration
(cattle) but will be happy to use these skills on the buffoon who ordered this, with a rusty scalpel!
I did not add I am qualified in
castration
(cattle) but will be happy to use these skills on the buffoon who ordered this, with a rusty scalpel!
serenfach
in
Thyroid UK
2 years ago
Circulating Lipid Profiles Associated With Resistance to Androgen Deprivation Therapy in Localized Prostate Cancer
thousands of lipid species, which may provide insights into pathophysiologic processes.9 Lipid metabolism is linked to AR signaling and, in particular, resistance to ARPIs.10-12 For example, elevated circulating levels of ceramide, a type of sphingolipid, are associated with ARPI resistance in metastatic
castration
-resistant
thousands of lipid species, which may provide insights into pathophysiologic processes.9 Lipid metabolism is linked to AR signaling and, in particular, resistance to ARPIs.10-12 For example, elevated circulating levels of ceramide, a type of sphingolipid, are associated with ARPI resistance in metastatic
castration
-resistant
podsart
in
Advanced Prostate Cancer
1 month ago
Anyone prescribe Metformin for prostate cancer not for diabetes?
Docetaxel is a standard of care in metastatic
castration
-resistant prostate cancer (mCRPC), however it is still a palliative treatment with a median overall survival of ~3 years in the first line setting.
Docetaxel is a standard of care in metastatic
castration
-resistant prostate cancer (mCRPC), however it is still a palliative treatment with a median overall survival of ~3 years in the first line setting.
Shorehousejam
in
Advanced Prostate Cancer
2 years ago
Is Simvastatin more effective than the other statins, against PCa?
In
castration
-resistant LNCaPabl cells, enzalutamide combined with atorvastatin resulted in the most prominent growth inhibition. Notably, simvastatin and also rosuvastatin were able to increase the effect of enzalutamide in 22Rv1 cells.
In
castration
-resistant LNCaPabl cells, enzalutamide combined with atorvastatin resulted in the most prominent growth inhibition. Notably, simvastatin and also rosuvastatin were able to increase the effect of enzalutamide in 22Rv1 cells.
GeorgeGlass
in
Advanced Prostate Cancer
2 years ago
Updated trial fails to show any real benefit to metastasis-directed therapy (MDT) in oligometastatic patients
(HR=0.44) • Radiographic progression-free survival (rPFS) was not significantly different • Time to
castration
resistance was not significantly different • Overall survival was not significantly different • PFS increased by about 5-6 months regardless of whether there were high-risk mutations (BRCA
(HR=0.44) • Radiographic progression-free survival (rPFS) was not significantly different • Time to
castration
resistance was not significantly different • Overall survival was not significantly different • PFS increased by about 5-6 months regardless of whether there were high-risk mutations (BRCA
Tall_Allen
in
Advanced Prostate Cancer
2 years ago
Anyone with experience of FWGE? TNVANS asked the same question 3 years ago, but now there is this paper on a pilot clinical trial.
Fermented Wheat Germ Extract (FWGE) as a Treatment Additive for
Castration
-Resistant Prostate Cancer: A Pilot Clinical TrialRony Weitzen, Nava Epstein, Bernice Oberman, Rebecca Shevetz, Mate Hidvegi, Raanan Berger Nutrition and Cancer 74 (4), 1338-1346, 2022
Castration
-resistant prostate cancer (CRPC
Fermented Wheat Germ Extract (FWGE) as a Treatment Additive for
Castration
-Resistant Prostate Cancer: A Pilot Clinical TrialRony Weitzen, Nava Epstein, Bernice Oberman, Rebecca Shevetz, Mate Hidvegi, Raanan Berger Nutrition and Cancer 74 (4), 1338-1346, 2022
Castration
-resistant prostate cancer (CRPC
Graham49
in
Advanced Prostate Cancer
2 years ago
A Retrospective study indicates serial SBRT may be beneficial in Oligometastatic Prostate Cancer
Of the 25 patients, 15 (60%) had
castration
-sensitive disease and 10 (40%) had
castration
-resistant disease. Following the second SBRT course, 16 patients (64%) achieved a 50% or greater decline in PSA level (PSA50), Dr Kwon’s team reported.
Of the 25 patients, 15 (60%) had
castration
-sensitive disease and 10 (40%) had
castration
-resistant disease. Following the second SBRT course, 16 patients (64%) achieved a 50% or greater decline in PSA level (PSA50), Dr Kwon’s team reported.
Graham49
in
Advanced Prostate Cancer
2 years ago
225Ac-PSMA-617/177Lu-PSMA-617 tandem therapy of metastatic castration-resistant prostate cancer
I read about Rusland experience with tandem theraphy. Does anyone know if this type of tandem theraphy is available somewhere in Europe? https://pubmed.ncbi.nlm.nih.gov/31758224/
I read about Rusland experience with tandem theraphy. Does anyone know if this type of tandem theraphy is available somewhere in Europe? https://pubmed.ncbi.nlm.nih.gov/31758224/
MyDad76
in
Advanced Prostate Cancer
2 years ago
Optimizing Bone Health in Prostate Cancer
Dr Saad has been intimately involved in almost every important clinical trial in
castration
resistant prostate cancer over the last 20 years and presently sits on 6 steering committees of international clinical trials.
Dr Saad has been intimately involved in almost every important clinical trial in
castration
resistant prostate cancer over the last 20 years and presently sits on 6 steering committees of international clinical trials.
maley2711
in
Advanced Prostate Cancer
2 years ago
Interesting paper summarising state of art (2022) for ADT
From Chapter 7 “All four agents (docetaxel, abiraterone, enzalutamide, and apalutamide) have been FDA-approved for the treatment of metastatic,
castration
-sensitive prostate cancer and are now listed as category 1 recommendations within the NCCN guidelines.81 Treatment choice between agents for metastatic
From Chapter 7 “All four agents (docetaxel, abiraterone, enzalutamide, and apalutamide) have been FDA-approved for the treatment of metastatic,
castration
-sensitive prostate cancer and are now listed as category 1 recommendations within the NCCN guidelines.81 Treatment choice between agents for metastatic
Graham49
in
Advanced Prostate Cancer
2 years ago
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