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Ranolazine (used for angina) could potentially be repurposed for PCa. Only mouse studies so far.
“Treatment of cancer patients with lipid metabolic inhibitors like ranolazine could potentially re-activate the immune cells to restore and enhance cellular-mediated antitumor immunity and tumor regression.” Targeting Fat Oxidation in Mouse Prostate Cancer Decreases Tumor Growth and Stimulates Anti-Cancer
“Treatment of cancer patients with lipid metabolic inhibitors like ranolazine could potentially re-activate the immune cells to restore and enhance cellular-mediated antitumor immunity and tumor regression.” Targeting Fat Oxidation in Mouse Prostate Cancer Decreases Tumor Growth and Stimulates Anti-Cancer
Graham49
in
Advanced Prostate Cancer
2 months ago
Result of Liver Biopsy - Any Insights?
This is the result of my liver biposy. Any insights on the comment? ----- CLINICAL HISTORY>>:: Prostate Ca with hepatic mets ?Small cell transformation versus other. FINAL DIAGNOSIS>>:: LIVER NODULE, CORE BIOPSY: - POORLY DIFFERENTIATED PROSTATIC ADENOCARCINOMA WITH SMALL CELL TRANSFORMATION
This is the result of my liver biposy. Any insights on the comment? ----- CLINICAL HISTORY>>:: Prostate Ca with hepatic mets ?Small cell transformation versus other. FINAL DIAGNOSIS>>:: LIVER NODULE, CORE BIOPSY: - POORLY DIFFERENTIATED PROSTATIC ADENOCARCINOMA WITH SMALL CELL TRANSFORMATION
skiingfiend
in
Advanced Prostate Cancer
2 months ago
High risk vs. aggressive cancer
I understand the definition of high-risk prostate cancer (Gleason, PSA and/or spread), but that doesn't necessarily seem to be the same thing as aggressive cancer. How can aggressiveness be determined for high risk, localized cancer? Thanks for any insight and information.
I understand the definition of high-risk prostate cancer (Gleason, PSA and/or spread), but that doesn't necessarily seem to be the same thing as aggressive cancer. How can aggressiveness be determined for high risk, localized cancer? Thanks for any insight and information.
RugbyVLS
in
Advanced Prostate Cancer
2 months ago
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Epithelial Haemangiendothelioma - has anyone else been diagnosed with this rare cancer please?
Hello, Having been diagnosed with CLL back in February 2002 (age 50) I was successfully treated with FCR from August 2009 to February 2010 and remain MRD negative as at present. Breast cancer followed in April 2016, then bowel cancer in September 2018. A five year surveillance period followed the
Hello, Having been diagnosed with CLL back in February 2002 (age 50) I was successfully treated with FCR from August 2009 to February 2010 and remain MRD negative as at present. Breast cancer followed in April 2016, then bowel cancer in September 2018. A five year surveillance period followed the
alipali
in
CLL Support
2 months ago
brachytherapy
my hubbie has just had brachytherapy for stage 3 prostate and has been in great pain since Thursday. He’s been told it’s normal and to suck it up but he’s not sleeping and is struggling to wee without great pain (tears) . Any advice as to what has worked for you to manage post op brachytherapy please
my hubbie has just had brachytherapy for stage 3 prostate and has been in great pain since Thursday. He’s been told it’s normal and to suck it up but he’s not sleeping and is struggling to wee without great pain (tears) . Any advice as to what has worked for you to manage post op brachytherapy please
bikebabe
in
Prostate Cancer Network
2 months ago
High Testosterone Level Why?
It is nearly 2'years since I was admitted to hospital to discover I had decompensated liver disease. Now I am compensated with very good bloods, no meds, and healthy. except my testosterone level . It is constantly high around 40 nmol or approx 1135 :ng/dl .( Has been higher ) I'm 62 male and as
It is nearly 2'years since I was admitted to hospital to discover I had decompensated liver disease. Now I am compensated with very good bloods, no meds, and healthy. except my testosterone level . It is constantly high around 40 nmol or approx 1135 :ng/dl .( Has been higher ) I'm 62 male and as
Taffypaul
in
British Liver Trust
2 months ago
Thank you all
I wanted to get on here and thank everyone for there input on my questions about PIQRAY. After all my do diligence on PIQRAY my oncologist threw me a curve ball and decided to go with Verzenio faslodex and xgeva. Because i had higher % of Ers1 mutations then Pik3ca mutations. So this past thursday i
I wanted to get on here and thank everyone for there input on my questions about PIQRAY. After all my do diligence on PIQRAY my oncologist threw me a curve ball and decided to go with Verzenio faslodex and xgeva. Because i had higher % of Ers1 mutations then Pik3ca mutations. So this past thursday i
Justme153
in
SHARE Metastatic Breast Cancer
6 months ago
Now been advised cancer has spread to both lungs 😔
Spoke to my consultant yesterday, it seems my nurse specialist had not given me the correct information. Cancer signs are now on both lungs, in my peritoneal area, and under my spleen (not the spleen itself). I am getting some pain in my lung area and it's really worrying me 😔 Surgery is still
Spoke to my consultant yesterday, it seems my nurse specialist had not given me the correct information. Cancer signs are now on both lungs, in my peritoneal area, and under my spleen (not the spleen itself). I am getting some pain in my lung area and it's really worrying me 😔 Surgery is still
Kazzh
in
My Ovacome
2 months ago
Zometa
Insurance denied my Xgeva shot . Was told I had to do Zometa. Looking at the potential side effects ( stomach) Im not inclined. Been dealing with ibs and gerd for years and not really wanting to go with anything that will increase that situation. I've read that Zometa does nothing to prevent SRE events
Insurance denied my Xgeva shot . Was told I had to do Zometa. Looking at the potential side effects ( stomach) Im not inclined. Been dealing with ibs and gerd for years and not really wanting to go with anything that will increase that situation. I've read that Zometa does nothing to prevent SRE events
APK3
in
Advanced Prostate Cancer
2 months ago
FDA Clearance of IND Application for FK-PC101, a Novel Personalized Cancer Immunotherapy for Prostate Cancer
FK-PC101, another step in the right direction it seems! https://www.prnewswire.com/news-releases/cellvax-therapeutics-announces-fda-clearance-of-ind-application-for-fk-pc101-a-novel-personalized-cancer-immunotherapy-302046986.html
FK-PC101, another step in the right direction it seems! https://www.prnewswire.com/news-releases/cellvax-therapeutics-announces-fda-clearance-of-ind-application-for-fk-pc101-a-novel-personalized-cancer-immunotherapy-302046986.html
Maxone73
in
Advanced Prostate Cancer
2 months ago
Barrigel is now preferred over "SpaceOAR" gel?
Consulted by video with the doctor who is supposed to install my SpaceOAR in preparation for my IMRT. His first words were "we don't use SpaceOAR gel anymore. We use Barrigel." He explains it has fewer side effects but the same radiation absorption characteristics. Here is what "UroToday" says:
Consulted by video with the doctor who is supposed to install my SpaceOAR in preparation for my IMRT. His first words were "we don't use SpaceOAR gel anymore. We use Barrigel." He explains it has fewer side effects but the same radiation absorption characteristics. Here is what "UroToday" says:
mababa
in
Advanced Prostate Cancer
2 months ago
The Results are in
Hello wonderful people. Just a quick update as I am so relieved I had to tell you. I have just put the phone down from my fabulous ENT Consultant. She had just received the results of the mass from the lab and wanted to tell me the good news. No cancer but an haemangioma. She confided that she had really
Hello wonderful people. Just a quick update as I am so relieved I had to tell you. I have just put the phone down from my fabulous ENT Consultant. She had just received the results of the mass from the lab and wanted to tell me the good news. No cancer but an haemangioma. She confided that she had really
CecilyParsley
in
LUPUS UK
2 months ago
What AI Says About Supplements and Off-Label Drug Use Regarding Prostate Cancer
Sure wish I had this tool over 2 years ago when I started reading up although you can't 100% trust the answers. The tools are getting smarter. I'm a software developer and have early access to Google's Gemini Pro 1.5 AI model that was relased Feb 15 2024 claiming to have better 'scores' than all the
Sure wish I had this tool over 2 years ago when I started reading up although you can't 100% trust the answers. The tools are getting smarter. I'm a software developer and have early access to Google's Gemini Pro 1.5 AI model that was relased Feb 15 2024 claiming to have better 'scores' than all the
jazj
in
Advanced Prostate Cancer
2 months ago
AUS revision surgery?
I'm seeking advice on having a second AUS surgery. My background: I had a prostatectomy in 2016 and radiation a year later because the cancerous tumor had penetrated the sack. I have since had undetected PSA but have suffered with severe stress incontinence. I had AUS surgery in 2018 but it failed because
I'm seeking advice on having a second AUS surgery. My background: I had a prostatectomy in 2016 and radiation a year later because the cancerous tumor had penetrated the sack. I have since had undetected PSA but have suffered with severe stress incontinence. I had AUS surgery in 2018 but it failed because
allnewstuff
in
Advanced Prostate Cancer
2 months ago
Xeloda
This may be long! Moms journey with mbc started in 2020 . At the time lung Mets . She started ibrance and femara which worked great untill it didn’t this summer 2023. The cancer had spread to bones and 2 small liver and lesion and tiny brain lesion . Which was been taken care of with radiation and
This may be long! Moms journey with mbc started in 2020 . At the time lung Mets . She started ibrance and femara which worked great untill it didn’t this summer 2023. The cancer had spread to bones and 2 small liver and lesion and tiny brain lesion . Which was been taken care of with radiation and
Flower1513
in
SHARE Metastatic Breast Cancer
6 months ago
Feasibility of someone from out of USA joining a clinical trial in USA?
My father has Prostate cancer (stage IV) and High Grade Neuro-endocrine cancer / Small Cell Carcinoma in liver. His six doses of Chemotherapy (carboplatin + etoposide) that ended seven weeks earlier. My understanding is that chemotherapy is the established regimen for High Grade NE Cancer/SCC. Are
My father has Prostate cancer (stage IV) and High Grade Neuro-endocrine cancer / Small Cell Carcinoma in liver. His six doses of Chemotherapy (carboplatin + etoposide) that ended seven weeks earlier. My understanding is that chemotherapy is the established regimen for High Grade NE Cancer/SCC. Are
RindaMan
in
Advanced Prostate Cancer
2 months ago
Nano Knife Surgery
I recently underwent a brand new surgical procedure called nano knife. Dr. Mayank Patel in Encino California, a da Vinci robotic and TULSA pro expert surgeon recommended this procedure after a panel of doctors examined my MRI and CT scans. The procedure was successful and five months post surgery
I recently underwent a brand new surgical procedure called nano knife. Dr. Mayank Patel in Encino California, a da Vinci robotic and TULSA pro expert surgeon recommended this procedure after a panel of doctors examined my MRI and CT scans. The procedure was successful and five months post surgery
HangIn66
in
Prostate Cancer Network
2 months ago
Janux immunotherapy drug (JANX007) for mCRPC
Are folks familiar with this treatment, JANX007? If something like this were rolled out, how widespread could it be given? I'm not very familiar with immunotherapy treatments. https://investors.januxrx.com/investor-media/news/news-details/2024/Janux-Announces-Encouraging-Safety-and-Efficacy-Data-in-Ongoing-Dose-Escalation-Trials-for-PSMAxCD3
Are folks familiar with this treatment, JANX007? If something like this were rolled out, how widespread could it be given? I'm not very familiar with immunotherapy treatments. https://investors.januxrx.com/investor-media/news/news-details/2024/Janux-Announces-Encouraging-Safety-and-Efficacy-Data-in-Ongoing-Dose-Escalation-Trials-for-PSMAxCD3
nyc_son
in
Advanced Prostate Cancer
2 months ago
Moving on to hospice care
many of you have heard from me before at this point. My dad (68, diagnosed almost 2 years ago) had his last appointment with his MO two weeks ago or so. Radium 223 is out of the picture for him as he is just not well and it would not aid his survival at this point. They suggested some radiation for the
many of you have heard from me before at this point. My dad (68, diagnosed almost 2 years ago) had his last appointment with his MO two weeks ago or so. Radium 223 is out of the picture for him as he is just not well and it would not aid his survival at this point. They suggested some radiation for the
StayingSTRNG
in
Advanced Prostate Cancer
2 months ago
Next Steps
My brother was dDiagnosed in March 2023 with widespread prostate cancer metastasized to the spine, pelvic bones, ribs both left and right, and skull and lymph nodes. No progression to any organs. He had a orchiectomy, is on ABIRATERONE 500MG and has just completed six treatments of Doxetaxel .
My brother was dDiagnosed in March 2023 with widespread prostate cancer metastasized to the spine, pelvic bones, ribs both left and right, and skull and lymph nodes. No progression to any organs. He had a orchiectomy, is on ABIRATERONE 500MG and has just completed six treatments of Doxetaxel .
Sparlingo
in
Advanced Prostate Cancer
2 months ago
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