Intraductal Prostate Carcinoma

[bdrakes]

Just wanted to say hello as this is a new journey. Hopefully most of you are experiencing success better than anticipated from the onset. . I share many of your diagnosis but for any of you out there with the more (rare) - intraductal Carcinoma diagnosis I'd love to see if it's possible to connect or ever better create a "community" group within the Health Unlocked site if that's possible? Just had Radical P. on 4.4.24 and looking for the few that have/closely resemble similar diagnosis; Intraductal Carcinoma, Gleason 9, Cribiform/PNI/Stage 3 , perineural invasion. Hoping I can learn from and share hopefully more often than not success stories, coping, challenges, advice. For the Intraductal PC world to a "newbie" only four months into this journey it seems to be a small minority of the overall "PC" community and might be best served by an independent community? Never like many out there saw myself in this club but hoping a separate community already exists? If anyone has any leads it would be appreciated as it seems overwhelming when filtering through hundreds of non-intraductal PC posts. Thanks in advance.

[Tall_Allen]

Adjuvant salvage radiation should begin ASAP:

prostatecancer.news/2021/10...

[bdrakes in reply to Tall_Allen]

Thank you kindly for this information and quick response. It is of great help.

[Don717]

I've read all I can about IDC over the last 2 years and there just isn't any SOC concerning it. Some say bad, some say doesn't matter, etc. My surgeon just shrugged his shoulders and said he sees it in about 30% of grade 4 cases and it doesn't change any SOC treatment in his opinion. My uro said he treats it like any other PC. I went to a MO consult when my surgical pathology came back and she said no secondary treatment unless I had any hint/indication clinically of cancer outside the prostate in my pathology which I did not...no PSM, SVI, LVI, EPE, PNI, LNI, etc etc. I've been <.01 for 29 months now. So I decided to stop worrying about IDC and start living.

You do have elevated BCR risks with the PNI and I think that's what TA is getting at. Salvage radiation for the PNI since you do have high-risk disease. The only consensus that I've read is hit all PC hard and early no matter the grade for best chances of BCR free survival.

Good luck to you on your journey sir!

[bdrakes in reply to Don717]

Thank you Don. Your insights are greatly appreciated and glad to hear you're last 29 months have been favorable. I'm taking your approach that hitting PC hard and early is best course of action.

[Melzer2169]

not aware of an existing forum or how to start a "sub-group" but would be interested and I've kept he "ID/names" of a couple of other ppl on here that are in same boat.

[bdrakes in reply to Melzer2169]

Hi Melzer. Thanks for taking the time to respond. If you have ID/Names or anyone else not in this thread please feel free to send over or post at some point as the more that can correspond might help one if not all of us. Thanks Melzer

[j-o-h-n]

Greetings bdrakes,

I just did a search of our history file and only found four occasions when I got a hit on the string "intraductal Carcinoma". Please update your bio, thanks!!!Best place is here for info and camaraderie.

Good Luck, Good Health and Good Humor.

j-o-h-n

[bdrakes in reply to j-o-h-n]

Thanks John. I do agree we have to laugh our way out of a mess sometimes. This one is so big of a mess that I actually have been laughing more and it's helping keep myself calm. Just learning this site's nuances as I go but appreciate your welcome.

[j-o-h-n]

SORRY, THERE ARE ONLY 3 POSTS, NOT 4 POSTS REGARDING Intraductal Carcinoma THAT I FOUND IN OUR HISTORY FILE:

HERE THEY ARE: (WITH OR WITHOUT RESPONSES FROM THE GROUP).

Good Luck, Good Health and Good Humor..

j-o-h-n Wednesday 05/15/2024 11:56 AM DST

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Intraductal Carcinoma....what's ahead?

Melzer2169 profile image

Melzer2169•

1 year ago•34 Replies <-------<<<

My husband (56) just received his final pathology report after his prostatectomy. T3a Gleason 4+3 (70% 4), Intraductal Carcinoma identified and Cribiform glands Present. EPE (non-focal) right posterior mid. no nodes involved and SV clear.

Prior to surgery his PSA was low, only 1.78 (but he was taking finasteride, so i understand we should think of that PSA more like 3.56...but that still isn't very high. he had no issues, cancer found during a colonoscopy & DRE that was done during that procedure. He also had a PSMA PET which did not show any cancer in other parts of his body, had a Decipher test that was .98 (which was scary to us)

I have tried to find info on this intraductal carcinoma and what i have found seems not good news.....we don't meet with dr until Jan (seems like forever away, will try to get something sooner).

Interested to hear if others had this and what does it mean for the treatment ahead. I like knowing the truth, so we can be better prepared.

Thanks in advance for any insights, experiences you may be willing to share.

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Melzer2169 profile image

Melzer2169

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Intraductal Carcinoma and Cribriform Glands Present

ToryCarlisle profile image

ToryCarlisle•

1 year ago•6 Replies <-------<<<

Hi!

Am wondering if anyone can speak to intraductal carcinoma and cribriform glands. My husband just had a prostatectomy several weeks ago. Follow up appt with surgeon is next week. Overall the pathology report seems good! They downgraded his Gleason score from a 9 to a 7 (4+3), margins were clean, and lymph nodes negative. But they did note intraductal carcinoma and cribriform glands. I've tried to do some reading on both, but would like to hear from anyone with similar results.

Am hopeful since the prostate has been removed he'll be good to go!

Thanks!

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ToryCarlisle profile image

ToryCarlisle

Female

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Intraductal Carcinoma & Cribiform pattern 4 treatment options?

FMOH_N profile image

FMOH_N•

10 months ago•11 Replies <-------<<<

Newly dx. PCa. with Intraductal carcinoma, IDC-P. This is the most aggressive prostate cancer type. In my case 4+3 with 70% pattern 4 with cribriform which make it even more worse. There are four types of pattern 4 (poorly formed glands, glomeruloid structures, cribriform glands, and fused glands) and the presence of cribriform glands is associated with an aggressive clinical course compared with other architectural subtypes.

I am reading that the IDC-P has poor response to ADT, CT (chemo), and external beam radiation.

Anyone who has news on recent/upcoming medications, clinical trials or alternatives to existing ones?

pubmed.ncbi.nlm.nih.gov/229....

"..........Recent clinical studies report that IDC-P is associated with neoadjuvant androgen deprivation therapy (ADT) and, chemotherapy (CT) failure as well as early disease recurrence after external beam radiation. Finally, IDC-P is associated with TMPRSS2-ERG gene fusion, which was reported to be regulated by estrogens and their receptors........."

pubmed.ncbi.nlm.nih.gov/289...

"Conclusion: The study showed that IDC-P is prevalent in aggressive prostate cancer and contains cells that can withstand androgen deprivation. Thus, IDC-P appears functionally relevant in advanced prostate cancer. The presence of IDC-P may be a trigger to develop innovative clinical management plans."

Here are some good reading and research articles:

ncbi.nlm.nih.gov/pmc/articl...

mdpi.com/article/10.3390/ca...

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FMOH_N profile image

FMOH_N

Male59 years oldNorway

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[bdrakes in reply to j-o-h-n]

Three is better than none. I appreciate this help.. Just reached out to Tory on your thread. She hasn't posted in eleven months but hopefully she gets back online soon. Thanks John

[FMOH_N]

Here are some statistics: modernpathology.org/article...

[FMOH_N]

ro-journal.biomedcentral.co...