Started Phase 1 trial - RO7656594 yesterday

[Yadifan]

Started clinical trial through Honor Health Research in Scottsdale yesterday. Day one was intense with multiple labs and EKG's after his first dose. Appointments today and tomorrow without the med but with follow up labs/EKG's. Friday's appointment will be the start of daily medication. Bone scans and CT scans will be done every 6 weeks.

Scans were done last week prior to starting this trial. The CT scan showed the lesion on his liver doubled in size from his January scan with 3 new lesions. It's been 6 weeks since my husband last had chemo. And it was failing before that, so I guess I shouldn't be surprised but it was disappointing to see that. Upsetting is probably more truthful. We're optimistic about this trial. This team is cautious and thorough. We are grateful for this opportunity. I was nervous about this being a phase one trial at first. Feeling better about this as we go through it.

Will post with updates when we get them. Seems to be a few here on HU on clinical trials right now. Best of luck to all of you. Encouraging to know there's so much on the horizon.

[God_Loves_Me]

I was reading about it after your post. Looks promising

[Yadifan in reply to God_Loves_Me]

I haven't found much on it. But it does seem promising.

[KocoPr]

I wish him well and success!

cancer.gov/research/partici...

A Study Evaluating the Safety, Pharmacokinetics, and Activity of RO7656594 In Participants With Advanced or Metastatic Prostate Cancer

[Yadifan in reply to KocoPr]

Thank you! We're cautiously optimistic.

[Maxone73]

fight on!!

[Yadifan in reply to Maxone73]

Thank you! You fight on also!

[KocoPr]

since we’re talking Androgen receptor degraders;

Here is a 2024 article on them.

Insight into Recent Advances in Degrading Androgen Receptor for Castration-Resistant Prostate Cancer

ncbi.nlm.nih.gov/pmc/articl...

[Yadifan in reply to KocoPr]

This!!! This is what I needed! Thank you so much. I just skimmed it but will do the deep dive later tonight.

[Scout4answers]

So glad you are in this trial, may the force be with you. Keep us up to date.

[Yadifan in reply to Scout4answers]

Thank you! Will do!

[rsgdmd]

I'm on a clinical trial for an AR degrader ARV-766. Lots of visits and labs as you describe. PSA dropped 50% after 2 weeks, another 10% at 4 weeks, BUT, bounced back up to 2 week level at 6 weeks. Bone pain, which was pretty bad before starting trial and had largely subsided, is starting to get bad again. Not a positive sign. I go for scans and labs next week, so will see. Had great hopes for this...... I wish you success.

[Yadifan in reply to rsgdmd]

Thank you. We have high hopes also. I think you need to when you enter these trials. This clinical trial team has talked about gauging the success by results of scans more than anything else. But it's hard not to pay attention to body pain and PSA results. Please post after you get your results from scans. Do you have a treatment lined up if this one doesn't work.

[rsgdmd in reply to Yadifan]

I will and I do have plan B. Thanks

[leo2634]

Never give up Never surrender.

[Yadifan in reply to leo2634]

Never give up. Never surrender.

[garyjp9]

Wishing him great success in the trial.

[Yadifan in reply to garyjp9]

Thank you!

[dockam]

Sending so much Love💙 and many Prayers for you two🙏

May this treatment degrade the heck outta that dang AR - the bane of PCa victims

youtu.be/0wQMSbAcBgw?si=317...(Not working as expected?)

catholicfaithstore.com/dail...

Fight on

QoL on

Me ke Aloha Pumehana - With warm Love

Randy

[Yadifan in reply to dockam]

That was beautiful!! Thank you Randy!! Appreciate your faith, support and pumehana!

[dockam]

YW Sista - We are Ohana (family) here and we Support/Love each other💙.

youtu.be/mSLxD9gt2U0?si=WuO...(Not working as expected?)

youtu.be/YWcFnN77-sM?si=_sa...(Not working as expected?)

My Best to you both on this next Chapter

Mahalo for your Love/Support

[Lavender22]

Good luck! And keep us posted.

[Yadifan in reply to Lavender22]

Thank you! Will do. Hope your husband is doing well on provenge.

[Lavender22]

Thanks, Y.

My husband completed the 2nd set (of3) of the Provenge transfusion/infusion therapy yesterday. His onc does not have a lot of clinical experience with it so is right with him to check all the SEs and procedural process. But she also confers with a consortium of oncs who meet regularly to discuss their patients. Together they decided it was a good “next treatment” for him after the Abiraterone stopped working.

So, one more of these sessions to go in 2 weeks and then we hold our breath and wait for scans to show if his immune system has kicked in against the 3 bone lesions that appeared.

He has hit the 4 year survival mark, so of course aiming for at least double that.

It is a harrowing path! And we try to keep life normal in between the roughest spots and as Warren Zevon said, enjoy every sandwich!

Best to you both-Elisa

[Yadifan in reply to Lavender22]

Yes! It is a harrowing path! Hoping for good news for you both. Love the Zevon quote!