Two or three years of ADT?

[BobC1234]

My two-year-course if Lupron and abiraterone will be done in March 2025. My MO is saying 2 years is sufficient but I see some people suggesting 3 years.

My situation. Dx in Feb 2023, PSA of 27. Gleason 4+3, BRACA2+, PSMA Pet showed three lymph nodes in pelvic area. 73 years old. Also diabetic and hypertension but both under control.

My treatments: brachytherapy, imrt, lupron, abiraterone. SE’s have been tolerable. Have even been able to rebuild muscles after hip replacement, although gained an inch or two at waist.

what are pro/cons of 2 yes vs 3yrs of ADT. Should I ask for 3 years?

[Tall_Allen]

The clinical trial used 3 yrs of ADT and 2 years of abiraterone. Would 2 years of ADT work as well? Impossible to predict.

[BobC1234 in reply to Tall_Allen]

Thanks for response. That explains it. Basically no one knows if two years is just as good as three years. Did the trial compare 3 yrs of ADT + 2 yrs of abi vs neither of these?

Also a more generic question to help my understanding: do trials generally tend to experiment first with a large dosage and then over time the required dosage can then be finetuned downward through clinical practice experience?

TA, thanks so much for your contributions to this site.

[Tall_Allen in reply to BobC1234]

They tested 2 yrs abi + 3 yrs ADT vs 3 years of ADT. There is an ongoing clinical trial of 2 yrs of apalutamide+ADT vs 2 yrs of ADT. It just finished recruiting.

Dosage if the first thing they determine (Phase 1 trials).

[BobC1234 in reply to Tall_Allen]

Thx

[larry_dammit]

well I’ve been on a ADT now for 8 years, no talk of going off . Had hip surgery on my left hip ( partial ) but wouldn’t do it without pinning the right hip due to cancer in my femur . Recovery was easy on the left but the right has been a nightmare as a piece of bone chipped off .surgery June 12 th. Still on a walker for the pin 🤬🤬🤬. Good luck warrior

[BobC1234 in reply to larry_dammit]

Had right hip replaced six months ago and getting left hip done in a couple weeks. My first went well. Best wishes for your recovery.

[addicted2cycling]

Told my boys to *ride off into the sunset in 2015* 😱 😂

Actually, it was more like around 2:00pm EST 👍👍

The Pathologist did a biopsy to check and wrote a *side bar note* ---

*I can officially confirm that 10 pounds of BALLS can fit in a 5 pound sack*

[Sushupthi in reply to addicted2cycling]

😅😅😅

[j-o-h-n in reply to addicted2cycling]

The round ones or the square ones?

Good Luck, Good Health and Good Humor.

j-o-h-n

[Hailwood]

Been in ADT for almost 4.5 years and will remain so

[Mgtd]

Friend just received a coffee cup with a from one of her colleagues. It reads. Please do not confuse my MD with your google search.

So in your case do not confuse Some People with your MO who is directly familiar with your case.