WTF!! Something escaped my lens: phase 1 trial for solid tumors

[Maxone73]

From 2011...I must investigate where they are now, I thought HP90 inhibition through alvespimycin was something new (from one of the articles I have posted today), but it has been around at least since 2011...and look at the results (ok, single patient) on prostate cancer.

aacrjournals.org/clincancer...

"At 80 mg/m2 client protein (CDK4, LCK) depletion was detected and tumor samples from 3 of 5 patients confirmed HSP90 inhibition. Clinical activity included complete response (castration refractory prostate cancer, CRPC 124 weeks)"

UPDATE: they did not go on with that specific HP90 inhibitor (alvespimycin) because of toxicity...

[Samrecan]

Wow! This could have been such a life saver. I wonder why they don’t persist with such lines of attack and come up with dosage/drug modifications till it works. Probably a return on investment issue?

[Maxone73 in reply to Samrecan]

No, they are still trying the HSP90 pathway, just with some different drug.