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Phase III Study: Saruparib Combo with New Hormonal Agents in mCSPC +/- HRR Mutations: AUA 2024 EvoPAR-Prostate01 Trial
AUA 2024: EvoPAR-Prostate01: Phase III, Double-Blind, Placebo-Controlled, 2-Cohort, Randomized Study of Saruparib (AZD5305) in Combination with New Hormonal Agents in Patients with mCSPC +/- HRR Mutations (UroToday.com) The 2024 American Urological Association (AUA) annual meeting featured a session
AUA 2024: EvoPAR-Prostate01: Phase III, Double-Blind, Placebo-Controlled, 2-Cohort, Randomized Study of Saruparib (AZD5305) in Combination with New Hormonal Agents in Patients with mCSPC +/- HRR Mutations (UroToday.com) The 2024 American Urological Association (AUA) annual meeting featured a session
God_Loves_Me
in
Advanced Prostate Cancer
4 months ago
Any guidance appreciated!
Hi everyone, My Dad (77) diagnosed in January w/ stage 4 PC, mets to L5 spine. PET scan showed no other spots elsewhere. PSA was 19 at time of diagnosis, Gleason 10. BRCA negative. PSA is now at 0.2 since starting hormone therapy. Feeling good, no pain. Still works (owns his own company). Started
Hi everyone, My Dad (77) diagnosed in January w/ stage 4 PC, mets to L5 spine. PET scan showed no other spots elsewhere. PSA was 19 at time of diagnosis, Gleason 10. BRCA negative. PSA is now at 0.2 since starting hormone therapy. Feeling good, no pain. Still works (owns his own company). Started
LDC2024
in
Advanced Prostate Cancer
4 months ago
oligometastic
I had a PSMA scan that found 3 small spots. My MO and Radiation O decided to radiate the spots without ADT. PSA is 0.28
I had a PSMA scan that found 3 small spots. My MO and Radiation O decided to radiate the spots without ADT. PSA is 0.28
Howard53545
in
Advanced Prostate Cancer
4 months ago
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TRAP trial: radiotherapy combined with hormone therapy can help some advanced prostate cancer patients avoid chemotherapy
TRAP is maybe not the best name for a clinical trial, but hey… https://www.icr.ac.uk/news-archive/new-trial-finds-radiotherapy-combined-with-hormone-therapy-can-help-some-advanced-prostate-cancer-patients-avoid-chemotherapy
TRAP is maybe not the best name for a clinical trial, but hey… https://www.icr.ac.uk/news-archive/new-trial-finds-radiotherapy-combined-with-hormone-therapy-can-help-some-advanced-prostate-cancer-patients-avoid-chemotherapy
Maxone73
in
Advanced Prostate Cancer
4 months ago
Si Joint/back pain
Hi I have a history of back pain and endometriosis. I recently turned 50 and leading up to my period my si joint pain has suddenly got worse and it all goes into spasms and I literally can't do a lot. It's not great the rest of the month either. I had linked it to the menopause or back issues but
Hi I have a history of back pain and endometriosis. I recently turned 50 and leading up to my period my si joint pain has suddenly got worse and it all goes into spasms and I literally can't do a lot. It's not great the rest of the month either. I had linked it to the menopause or back issues but
AMS_1
in
Endometriosis UK
4 months ago
A-Dream iADT Protocol
It has been awhile since my last post. Short story is I responded well to the doublet therapy in Arasec (lupron+daro). MO believes there is some chance my M1B diagnosis at the start was incorrect (he refers to my case as 'discordant' - due to conflicting data - Gleason 6 but some spots lit up on
It has been awhile since my last post. Short story is I responded well to the doublet therapy in Arasec (lupron+daro). MO believes there is some chance my M1B diagnosis at the start was incorrect (he refers to my case as 'discordant' - due to conflicting data - Gleason 6 but some spots lit up on
Heykm01
in
Advanced Prostate Cancer
4 months ago
Neuropathy help?
Diagnosed June 2023, Started Lupron July, Zytiga and prednisone August, IMRT 28x 70gy, including distant oligometastatic retroperitoneal lymph nodes November. Everything going fine only minor side effects and I feel good. Then, May 1st 2024 I have sudden onset of peripheral neuropathy. Wow, what a buzzkill
Diagnosed June 2023, Started Lupron July, Zytiga and prednisone August, IMRT 28x 70gy, including distant oligometastatic retroperitoneal lymph nodes November. Everything going fine only minor side effects and I feel good. Then, May 1st 2024 I have sudden onset of peripheral neuropathy. Wow, what a buzzkill
pj1121
in
Advanced Prostate Cancer
1 day ago
GP Coming - what to ask
having my annual review tomorrow and GP is coming to see me. Looking at all my past results I wonder, with them being up and down constantly, whether I am one of those whereby Levo no longer works for me and might be keeping me ill. Diagnosed back in 2005 and it's too far back to remember how I was
having my annual review tomorrow and GP is coming to see me. Looking at all my past results I wonder, with them being up and down constantly, whether I am one of those whereby Levo no longer works for me and might be keeping me ill. Diagnosed back in 2005 and it's too far back to remember how I was
Jefner
in
Thyroid UK
4 months ago
Is this something that needs investigating/Or Thoughts on cause?
Im 46 F. Mild on/off non bothering pain for 2 year's. If it was a serious problem, would it have got worse by now as it hasnt and just comes and goes since then? It's more the not knowing the cause, than the pain that bothers me. It started in the left breast and armpit. (I've put the breast pain down
Im 46 F. Mild on/off non bothering pain for 2 year's. If it was a serious problem, would it have got worse by now as it hasnt and just comes and goes since then? It's more the not knowing the cause, than the pain that bothers me. It started in the left breast and armpit. (I've put the breast pain down
Milky99
in
Women's Health
7 months ago
Walsh's Folly?
I posted earlier that I had to ask ChatGPt "who came up with the 'gasoline on a fire' characterization regarding the relationship of testosterone and prostate cancer" and that Chat GPT had answered -- Dr. Patrick Walsh -- (father of the radical prostatectomy.) In that post, discussion turned to Walsh's
I posted earlier that I had to ask ChatGPt "who came up with the 'gasoline on a fire' characterization regarding the relationship of testosterone and prostate cancer" and that Chat GPT had answered -- Dr. Patrick Walsh -- (father of the radical prostatectomy.) In that post, discussion turned to Walsh's
VoxHope
in
Advanced Prostate Cancer
4 months ago
Life after ADT
Hello, I finished my ADT treatment 7 months ago ( ORGOVYX for 22 months . Still having emotional rollercoaster. Held my own during the cancer journey ( Brachy therapy, 25 sessions of IMRT, then ORGOVYX. I guess I was lucky only mind numbing, soul crushing fatigue, bad brain fog/confusion, shrunken
Hello, I finished my ADT treatment 7 months ago ( ORGOVYX for 22 months . Still having emotional rollercoaster. Held my own during the cancer journey ( Brachy therapy, 25 sessions of IMRT, then ORGOVYX. I guess I was lucky only mind numbing, soul crushing fatigue, bad brain fog/confusion, shrunken
watertender
in
Advanced Prostate Cancer
12 days ago
COMBINATION THERAPY IS NOW UNDER REVIEW
This review indicates how and why combination therapy may be used in treatment. Interesting in itself, but another example of cherry-picking evidence ( we aren't mentioned in spite of starting this concept in 2012. Good cliquish admission where the "nonprofessionals"are best kept well out of the limelight
This review indicates how and why combination therapy may be used in treatment. Interesting in itself, but another example of cherry-picking evidence ( we aren't mentioned in spite of starting this concept in 2012. Good cliquish admission where the "nonprofessionals"are best kept well out of the limelight
diogenes
in
Thyroid UK
9 months ago
Celebrex and Curcumin and Magnesium.
I recently received a question from a fellow warrior based on a comment I had made on an older post that he had started. The question was what I thought about Naproxen compered to Celebrex and I told him I had very limited experience with Naproxen. I then clicked on older posts about nsaids and prostate
I recently received a question from a fellow warrior based on a comment I had made on an older post that he had started. The question was what I thought about Naproxen compered to Celebrex and I told him I had very limited experience with Naproxen. I then clicked on older posts about nsaids and prostate
Professorgary
in
Advanced Prostate Cancer
4 months ago
Unfavorable Intermediate PCa--treatment
Treated at UCSF. Chose radiation plus 4 months ADT (Orgovyx) due to concern of local meta. Dr. Shinohara performed tp biopsy and tp placement of markers. Alexander Gottschalk is my RO. Treatment: commencing 2 months after start of ADT, 2 fractions of Cyberknife to prostate. 25 fractions IMRT
Treated at UCSF. Chose radiation plus 4 months ADT (Orgovyx) due to concern of local meta. Dr. Shinohara performed tp biopsy and tp placement of markers. Alexander Gottschalk is my RO. Treatment: commencing 2 months after start of ADT, 2 fractions of Cyberknife to prostate. 25 fractions IMRT
gualala
in
Prostate Cancer Network
20 days ago
Quick update on my journey
My bio has most of the brief history of my recent diagnosis. I’m on month 3 of Xtandi plus Orgovyx and just met with Rad Onc at Duke for initial consultation. Plan is low dose IMRT over 20 days (every day for 5 days in a row each week). Expect to remain on existing doublet Tx for at least the next
My bio has most of the brief history of my recent diagnosis. I’m on month 3 of Xtandi plus Orgovyx and just met with Rad Onc at Duke for initial consultation. Plan is low dose IMRT over 20 days (every day for 5 days in a row each week). Expect to remain on existing doublet Tx for at least the next
Clippedwingz
in
Prostate Cancer Under 60
21 days ago
Would be grateful for your thoughts on my blood results before endo apt please, still feeling exhausted and weak. Thank you
Hello, I’ve had an underactive thyroid for 8 years after having my first child, looks like Hashimotos. Currently taking 100mcg levothyroxine and 15mcg liothyronine (10mcg on waking and 5 around 3pm). Also on HRT patches as am mid 40s and perimenopausal. I’m gluten free, have had SIBO in the past.
Hello, I’ve had an underactive thyroid for 8 years after having my first child, looks like Hashimotos. Currently taking 100mcg levothyroxine and 15mcg liothyronine (10mcg on waking and 5 around 3pm). Also on HRT patches as am mid 40s and perimenopausal. I’m gluten free, have had SIBO in the past.
Hopetoheal22
in
Thyroid UK
4 months ago
Waiting for the Other Shoe to Drop
61 with oligometastatic prostate cancer. PSA is currently down to 0.02 today after 6 months of Lupron and Erleada from PSA 150 in late Dec. '23. Started on Megestrol Acetate back in April, really reduced the side effects of ADT for me. My figure also looks about the as before treatment. I had a trans-rectal
61 with oligometastatic prostate cancer. PSA is currently down to 0.02 today after 6 months of Lupron and Erleada from PSA 150 in late Dec. '23. Started on Megestrol Acetate back in April, really reduced the side effects of ADT for me. My figure also looks about the as before treatment. I had a trans-rectal
TheLarch
in
Advanced Prostate Cancer
24 days ago
"Gasoline" Source
I have been trying to find the source for the observation? that "Testosterone to prostate cancer is like gasoline on a fire". I finally asked Bing Copilot and ChatGPT-- who came up with the answer. Me: What is the source of the "gasoline on a fire" theory in prostate cancer? ChatGPT: Dr. Patrick
I have been trying to find the source for the observation? that "Testosterone to prostate cancer is like gasoline on a fire". I finally asked Bing Copilot and ChatGPT-- who came up with the answer. Me: What is the source of the "gasoline on a fire" theory in prostate cancer? ChatGPT: Dr. Patrick
VoxHope
in
Advanced Prostate Cancer
4 months ago
What comes after, what comes next?
I have posted a few times about my dad. Stage 4, mets to 8+ bones at time of diagnosis, PSA at 137 (10/22.) Lupron twice a year, Bicalutamide, failed at 7 months, Xtandi failed at 4 months, currently on Zytiga. We met with my dad’s oncologist on 4/24. My Dad’s PSA dropped from 2.47-1.46 and pain has
I have posted a few times about my dad. Stage 4, mets to 8+ bones at time of diagnosis, PSA at 137 (10/22.) Lupron twice a year, Bicalutamide, failed at 7 months, Xtandi failed at 4 months, currently on Zytiga. We met with my dad’s oncologist on 4/24. My Dad’s PSA dropped from 2.47-1.46 and pain has
lgutman
in
Advanced Prostate Cancer
4 months ago
hrt increase
Hi l recently increased my hrt patch from 50 to 75 and am experiencing body aches and prickly skin sensations. Is this normal? Also quite emotional too.
Hi l recently increased my hrt patch from 50 to 75 and am experiencing body aches and prickly skin sensations. Is this normal? Also quite emotional too.
RayannAbbey
in
Anxiety and Depression Support
4 months ago
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