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Overall Survival With [177]Lu-PSMA-617 vs Cabazitaxel in Metastatic Castration-Resistant Prostate Cancer
The Lancet Oncology TAKE-HOME MESSAGE TheraP was a phase II trial that compared the efficacy of radioligand therapy with 177Lu-PSMA-617 with that of cabazitaxel in patients with metastatic castration-resistant prostate cancer who had previously received docetaxel. After a median follow-up of 35.7 months
The Lancet Oncology TAKE-HOME MESSAGE TheraP was a phase II trial that compared the efficacy of radioligand therapy with 177Lu-PSMA-617 with that of cabazitaxel in patients with metastatic castration-resistant prostate cancer who had previously received docetaxel. After a median follow-up of 35.7 months
Magnus1964
in
Advanced Prostate Cancer
6 months ago
"Two Invitae CHEK2 variants of "unknown consequence""
Hello - My Hopkins MO says this genetics test indicates a weakness (CHEK2 is one of the 4 or 5 PCa related variants) he thinks this could have contributed to my premature, two year BCR after RP, so he will likely prescribe chemo sooner than later though PSA will be the prime indicator. Further he suggested
Hello - My Hopkins MO says this genetics test indicates a weakness (CHEK2 is one of the 4 or 5 PCa related variants) he thinks this could have contributed to my premature, two year BCR after RP, so he will likely prescribe chemo sooner than later though PSA will be the prime indicator. Further he suggested
jackwfrench
in
Advanced Prostate Cancer
6 months ago
Criteria for "my ADT has stopped working and we have to move to another"
Hello - So my third post ADT initiation (Lupron+Abi) PSA test is coming up and since it was <.1 six weeks ago, I asked how the criteria of “has stopped working” works -to my Hopkins MO and I got this - “We want to declare a therapy no longer effective when PSA is clearly going up. We look for 0.3
Hello - So my third post ADT initiation (Lupron+Abi) PSA test is coming up and since it was <.1 six weeks ago, I asked how the criteria of “has stopped working” works -to my Hopkins MO and I got this - “We want to declare a therapy no longer effective when PSA is clearly going up. We look for 0.3
jackwfrench
in
Advanced Prostate Cancer
6 months ago
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First PSA post surgery
Hello, Just had my first 3 month PSA test post surgery. <0.01. Good news but need to monitor every 3 years due to intraductal component. I just want to thank everyone that has been so supportive and has given me positive feedback on this forum. I am also getting genetic testing done this week as well
Hello, Just had my first 3 month PSA test post surgery. <0.01. Good news but need to monitor every 3 years due to intraductal component. I just want to thank everyone that has been so supportive and has given me positive feedback on this forum. I am also getting genetic testing done this week as well
Granolaberry
in
Prostate Cancer Network
1 month ago
Promising, especially for people with LBD mutation: NEJM Evidence publishes results from Phase I/IIa CYPIDES trial with ODM-208
"In phase I, 20 out of the total 47 patients had AR LBD mutation. In phase IIa, all 45 patients had AR LBD mutation. A decrease in PSA (prostate-specific antigen) levels of 50% or more occurred in 14/19 (73.7%) patients with AR LBD mutation and 2/23 (8.7%) AR-wild-type patients in phase I, and in 24/
"In phase I, 20 out of the total 47 patients had AR LBD mutation. In phase IIa, all 45 patients had AR LBD mutation. A decrease in PSA (prostate-specific antigen) levels of 50% or more occurred in 14/19 (73.7%) patients with AR LBD mutation and 2/23 (8.7%) AR-wild-type patients in phase I, and in 24/
Maxone73
in
Advanced Prostate Cancer
6 months ago
Prostate cancer
My prostate condition started around eight years ago when I had urinary track infection which also led to prostatitis. Ever since then, my PSA jumped from 2 to 7.8 during the last 5 years. I had two biopsies… first one, four years ago, they detected no positive cancer cells in my prostate. However
My prostate condition started around eight years ago when I had urinary track infection which also led to prostatitis. Ever since then, my PSA jumped from 2 to 7.8 during the last 5 years. I had two biopsies… first one, four years ago, they detected no positive cancer cells in my prostate. However
Yuncoinc7148
in
Fight Prostate Cancer
6 months ago
Lymparza not working
hi..my husband was initially diagnosed stage 4b in 2020. He did well on chemo, and lupron. He is also on xgeva. He then went on zytiga for about 7 months before it started failing. He did get accepted in the luteciun trial at Penn on control arm. He did very well on Xtandi but was ended this past Aug
hi..my husband was initially diagnosed stage 4b in 2020. He did well on chemo, and lupron. He is also on xgeva. He then went on zytiga for about 7 months before it started failing. He did get accepted in the luteciun trial at Penn on control arm. He did very well on Xtandi but was ended this past Aug
Happy1985
in
Advanced Prostate Cancer
6 months ago
Ketogenic diet for High risk PCA? American Ginseng for fatigue?
Reaching out for feedback regarding adopting a more ketogenic diet for my husband and using an american ginseng supplement for fatigue. Worth while? Husband is Gleason 9, PSA 46.6 when diagnosed, completed 28 Proton treatments, on Orgovyx and started Abiraterone and prednisone recently. Being treated
Reaching out for feedback regarding adopting a more ketogenic diet for my husband and using an american ginseng supplement for fatigue. Worth while? Husband is Gleason 9, PSA 46.6 when diagnosed, completed 28 Proton treatments, on Orgovyx and started Abiraterone and prednisone recently. Being treated
CancerConcierge
in
Advanced Prostate Cancer
6 months ago
Confusing news from oncologist
Hi all, looking for some insight or direction based off of any experiences or similar ones. My dad started chemo in October with a PSA of 126. After 2 rounds of chemo, his PSA rose to 153, we saw some increase in his bone metastasis as according to the scans (posted about this previously). My dad
Hi all, looking for some insight or direction based off of any experiences or similar ones. My dad started chemo in October with a PSA of 126. After 2 rounds of chemo, his PSA rose to 153, we saw some increase in his bone metastasis as according to the scans (posted about this previously). My dad
StayingSTRNG
in
Advanced Prostate Cancer
6 months ago
Still confused about PSA and Testosterone testing
I have been reading posts here for some time and there seems to be a split between those who only get PSA tests each time they go to their doctors and those that get both tests each time. I had a baseline testosterone test before Lupron and before radiation. I am now doing my 6 month follow up and
I have been reading posts here for some time and there seems to be a split between those who only get PSA tests each time they go to their doctors and those that get both tests each time. I had a baseline testosterone test before Lupron and before radiation. I am now doing my 6 month follow up and
Mgtd
in
Advanced Prostate Cancer
6 months ago
Sterlings Reply
Please forgive the lateness but here it is:Four years after prostectomy my psa began to rise. I had eight weeks of radiation to the prostate bed. Psa returned to nondetectable for eleven years. Two years ago my psa began to rise at an alarming rate it was doubling monthly if not more. I started eligard
Please forgive the lateness but here it is:Four years after prostectomy my psa began to rise. I had eight weeks of radiation to the prostate bed. Psa returned to nondetectable for eleven years. Two years ago my psa began to rise at an alarming rate it was doubling monthly if not more. I started eligard
Praying2BHealthy
in
Advanced Prostate Cancer
6 months ago
Blood in Urine
Hi fellow fighters Had blood in my urine the last 10 days. Hoped it was a UTI but a course of antibiotics has failed. I had a bladder neck incision last June to help urinary flow. The urologist saw a suspicious patch and a biopsy confirmed it my prostate cancer has spread to my bladder. I’m hoping
Hi fellow fighters Had blood in my urine the last 10 days. Hoped it was a UTI but a course of antibiotics has failed. I had a bladder neck incision last June to help urinary flow. The urologist saw a suspicious patch and a biopsy confirmed it my prostate cancer has spread to my bladder. I’m hoping
Tonyliv
in
Advanced Prostate Cancer
6 months ago
Did not see that coming.
Hello to all, Dx 11-1-23. Went in with urinary situations and came out with a Turp and stage 4. had a Psma pet scan ..Mets here and there . So high volume I guess. PSA was 139 ..MO says triplet therapy ....seems like I'm pretty far down the road... I know I gain by doing the therapy but on average are
Hello to all, Dx 11-1-23. Went in with urinary situations and came out with a Turp and stage 4. had a Psma pet scan ..Mets here and there . So high volume I guess. PSA was 139 ..MO says triplet therapy ....seems like I'm pretty far down the road... I know I gain by doing the therapy but on average are
APK3
in
Advanced Prostate Cancer
6 months ago
Importance of ADT
Are there any good outcomes without using ADT ( hormone therapy)? I delayed it for a couple of years with bad results. My history -- [u]
2021
[/u]: Age 78. PSA was 7.79, Gleason 4+3=7. Small lesion in prostate, with perineural invasion. Had 20 IMRT for prostate. No ADT. [u]
2022
[/u]: PSA
Are there any good outcomes without using ADT ( hormone therapy)? I delayed it for a couple of years with bad results. My history -- [u]
2021
[/u]: Age 78. PSA was 7.79, Gleason 4+3=7. Small lesion in prostate, with perineural invasion. Had 20 IMRT for prostate. No ADT. [u]
2022
[/u]: PSA
vintage42
in
Advanced Prostate Cancer
6 months ago
Next steps after PBRT
Hi all - First and foremost, Happy Holidays. I had my prostate removed 8/22, with subsequent Proton Beam treatment ending 4/23 (after PSA did not drop to undetectable) brought upon after a mild uptake (during a Petscan) in an obturator lymph node. I’m on Orgovyx and Xtandi, with a plan to stay on them
Hi all - First and foremost, Happy Holidays. I had my prostate removed 8/22, with subsequent Proton Beam treatment ending 4/23 (after PSA did not drop to undetectable) brought upon after a mild uptake (during a Petscan) in an obturator lymph node. I’m on Orgovyx and Xtandi, with a plan to stay on them
Vp7174
in
Advanced Prostate Cancer
6 months ago
How do we determine if cancer is in remission
Just had my fourth of five Cyber Knife treatments and my doctor said everything has been going "great." It turns out that means when the treatment was performed my bladder was full and my rectum was empty. When I asked if another Petscan was on the horizon he told me that it was unlikely that my insurer
Just had my fourth of five Cyber Knife treatments and my doctor said everything has been going "great." It turns out that means when the treatment was performed my bladder was full and my rectum was empty. When I asked if another Petscan was on the horizon he told me that it was unlikely that my insurer
GrantB47
in
Advanced Prostate Cancer
6 months ago
Stage 4 A Prostate cancer
My partner was diagnosed with stage 4 A prostate cancer with spread to pelvic lymph nodes. Oncologist has recommended surgery followed by radiation and hormone therapy for a good prognosis. He is 65 healthy and no symptoms. PSA was 11. Has a history of prostrate cancer. Was wondering if we should get
My partner was diagnosed with stage 4 A prostate cancer with spread to pelvic lymph nodes. Oncologist has recommended surgery followed by radiation and hormone therapy for a good prognosis. He is 65 healthy and no symptoms. PSA was 11. Has a history of prostrate cancer. Was wondering if we should get
SherryKahn
in
Advanced Prostate Cancer
2 months ago
Remission
In remission since May 2018. All PSA testing from oncologist has ranged from .04 to .05. Why not have my internist take my PSA yearly? Or is going to my oncologist for testing the better way to go?
In remission since May 2018. All PSA testing from oncologist has ranged from .04 to .05. Why not have my internist take my PSA yearly? Or is going to my oncologist for testing the better way to go?
Coupe31
in
Advanced Prostate Cancer
6 months ago
still here
Hi All I like to try and update my journey so you can see that there are some longer term survivors. I am still on 0 PSA with advanced cancer. My journey is on my bio. I was diagnosed at 47 and now I’m 54 with no progression. My primary treatment was Zytiga and it is still working. I take a concoction
Hi All I like to try and update my journey so you can see that there are some longer term survivors. I am still on 0 PSA with advanced cancer. My journey is on my bio. I was diagnosed at 47 and now I’m 54 with no progression. My primary treatment was Zytiga and it is still working. I take a concoction
Apollo123
in
Advanced Prostate Cancer
6 months ago
PSA trippled since last Lupron infusion
My PSA was 0.05 between February 2023 and June 2023, then in September it ticked higher to 0.06 and at yesterday's Lupron injection it was 0.17. Should I be concerned? Anybody with similar experience: what did you do? Am I CR or still CS? Should I ask for Lu-177/Pluvicto ASAP? Thanks for reading.
My PSA was 0.05 between February 2023 and June 2023, then in September it ticked higher to 0.06 and at yesterday's Lupron injection it was 0.17. Should I be concerned? Anybody with similar experience: what did you do? Am I CR or still CS? Should I ask for Lu-177/Pluvicto ASAP? Thanks for reading.
Oldie68
in
Advanced Prostate Cancer
6 months ago
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