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Phase 1 trial participation Nurix NX-1607
I have not been on any treatment since I stopped Docetaxel chemo last year except Prostap injections every 12 weeks. My PSA went up from ~9 to 20 from May to September. I have just been invited to take part in a phase 1a safety and tolerability study of NX-1607. It aims to inhibit CBL-B (Casitas B-lineage
I have not been on any treatment since I stopped Docetaxel chemo last year except Prostap injections every 12 weeks. My PSA went up from ~9 to 20 from May to September. I have just been invited to take part in a phase 1a safety and tolerability study of NX-1607. It aims to inhibit CBL-B (Casitas B-lineage
konichiwa12
in
Advanced Prostate Cancer
6 months ago
Radiation PSA, Orgovyx, Bone density
Rouge clone radiation on 10/31/23 has PSA continuing to drop to 0.85. MO plans to monitor PSA before requesting PSMA scan (insurance) unless it is increasing. Considering switch from Eligard to Orgovyx if PSA looks good in early Feb since Orgovyx apparently has less severe SE and doesn't tie me to
Rouge clone radiation on 10/31/23 has PSA continuing to drop to 0.85. MO plans to monitor PSA before requesting PSMA scan (insurance) unless it is increasing. Considering switch from Eligard to Orgovyx if PSA looks good in early Feb since Orgovyx apparently has less severe SE and doesn't tie me to
alperk
in
Advanced Prostate Cancer
6 months ago
`psa level
I have now been on Firmagon (hormone therapy) for 23 months .I have stage 4+4 with an original PSA of 375.I had 6 rounds of chemo which killed off the majority of the cancer in bones and lungs.Only a couple of tiny spots in the lungs. My professor tells me i have had a very good result on many trips
I have now been on Firmagon (hormone therapy) for 23 months .I have stage 4+4 with an original PSA of 375.I had 6 rounds of chemo which killed off the majority of the cancer in bones and lungs.Only a couple of tiny spots in the lungs. My professor tells me i have had a very good result on many trips
Brianne07
in
Advanced Prostate Cancer
6 months ago
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Experience, thus far with Lupron and Abiraterone
I am 78 years old. I was diagnosed in May 2022 with PCa after my PSA was measured at 23.79. I have no other health issues. Following the determination that PCa was still within the prostrate capsule and had not spread to any other organ, I was placed on Lupron (6 monthly IM injections for 2 years). Clinically
I am 78 years old. I was diagnosed in May 2022 with PCa after my PSA was measured at 23.79. I have no other health issues. Following the determination that PCa was still within the prostrate capsule and had not spread to any other organ, I was placed on Lupron (6 monthly IM injections for 2 years). Clinically
Sanctus
in
Advanced Prostate Cancer
6 months ago
Testosterone increase after injection
I recently had my 6 month dose of Camcevi 42mg and my testosterone went from 7 t0 55 rights after the injection. My PSA remained the same at 0.1 . Is this normal for my testosterone to jump 48 points. Oncologist says he is more concerned with my PSA. Also the injection of the Camcevi was in my lower
I recently had my 6 month dose of Camcevi 42mg and my testosterone went from 7 t0 55 rights after the injection. My PSA remained the same at 0.1 . Is this normal for my testosterone to jump 48 points. Oncologist says he is more concerned with my PSA. Also the injection of the Camcevi was in my lower
Shadoz
in
Advanced Prostate Cancer
6 months ago
Is inconsistent bowel and urine part of the Prostate cancer? Also almost like dementia?
The last two months my husband has wet himself many times and almost many more times in the last week he has solid himself 3 times when we were out. He doesn't have diarrhea he says he can't tell he has to go until he HAS to go than it's to late. Also in the last two months he has done things like point
The last two months my husband has wet himself many times and almost many more times in the last week he has solid himself 3 times when we were out. He doesn't have diarrhea he says he can't tell he has to go until he HAS to go than it's to late. Also in the last two months he has done things like point
Bo1948
in
Advanced Prostate Cancer
6 months ago
PSA Roller Coaster ride!
Back a couple days ago, I posted a question about my PSA being undectable since July 2022. (<0.01) then this month is up to 2.22. I asked what is next etc. I had an appointment with my MO on 19 Dec 2023, they generally do lab work at the cancer center before they give me lupron. I ask them if
Back a couple days ago, I posted a question about my PSA being undectable since July 2022. (<0.01) then this month is up to 2.22. I asked what is next etc. I had an appointment with my MO on 19 Dec 2023, they generally do lab work at the cancer center before they give me lupron. I ask them if
JD-guy
in
Advanced Prostate Cancer
6 months ago
Change in PSA
My PSA has been <.064 for a couple years. This time it was <.05. The test is always done by the same lab. Does this mean anything?
My PSA has been <.064 for a couple years. This time it was <.05. The test is always done by the same lab. Does this mean anything?
epfj3333
in
Advanced Prostate Cancer
6 months ago
Prostate-Kidney and BPH Decision for treatment.
Hi everyone. Hoping to get some input from the collective experience and knowledge of the helpful people on this forum in making a decision on course of treatment. I apologize for length of post, but, with two issues (prostate and kidney) it took a bit to accurately explain. Newly diagnosed with Prostate
Hi everyone. Hoping to get some input from the collective experience and knowledge of the helpful people on this forum in making a decision on course of treatment. I apologize for length of post, but, with two issues (prostate and kidney) it took a bit to accurately explain. Newly diagnosed with Prostate
Seminole0412
in
Advanced Prostate Cancer
6 months ago
Nubeqa Vs Abiraterone
Which is more effective my PSA rising after being placed on Nubeqa. Prostate cancer metastasized to the bone
Which is more effective my PSA rising after being placed on Nubeqa. Prostate cancer metastasized to the bone
willie334
in
Advanced Prostate Cancer
6 months ago
Brain lesion
anybody here who experienced brain lesions that might be from PCa? Current PSA is 0.025. It’s just confusing that after ADT works to remove all the symptoms including bone pain from bone mets, my dad was diagnosed with brain lesion after an MRI since he had mild stroke symptoms(slurred speech). Does
anybody here who experienced brain lesions that might be from PCa? Current PSA is 0.025. It’s just confusing that after ADT works to remove all the symptoms including bone pain from bone mets, my dad was diagnosed with brain lesion after an MRI since he had mild stroke symptoms(slurred speech). Does
dnmrk
in
Advanced Prostate Cancer
6 months ago
After Radiation, what should PSA be?
intermediate pc, with 3+4, 3+4, and 4+3. PSMA clean. Went through SBRT, am on Lupron. Seven months in. usual side effects, especially exhaustion. I went for a PSA and testosterone test today. Should my PSA be undetectable?
intermediate pc, with 3+4, 3+4, and 4+3. PSMA clean. Went through SBRT, am on Lupron. Seven months in. usual side effects, especially exhaustion. I went for a PSA and testosterone test today. Should my PSA be undetectable?
Photographerhere
in
Prostate Cancer Network
6 months ago
I would like to update my dad's situation (type 4 prostate cancer and bone metastasis) - LIMA PERU
Good afternoon, I thank everyone for the answers you gave me in my previous post. I would like to update my dad's situation (type 4 prostate cancer and bone metastasis) perhaps it will serve someone's experience later and your advice will help me a lot. The medications you take: Omeprazole 7 AM Predisona
Good afternoon, I thank everyone for the answers you gave me in my previous post. I would like to update my dad's situation (type 4 prostate cancer and bone metastasis) perhaps it will serve someone's experience later and your advice will help me a lot. The medications you take: Omeprazole 7 AM Predisona
DiegoFerruaPE
in
Advanced Prostate Cancer
6 months ago
Back pain
I’m getting rear rib pain that I largely feel when lying down and in certain body movement. I do have a little spread to my front ribs. Not sure if this is something to worry about or yet another consequence of the PC and/or medication. My PSA is creeping up though my oncologist it not concerned at the
I’m getting rear rib pain that I largely feel when lying down and in certain body movement. I do have a little spread to my front ribs. Not sure if this is something to worry about or yet another consequence of the PC and/or medication. My PSA is creeping up though my oncologist it not concerned at the
FortyWinks
in
Advanced Prostate Cancer
6 months ago
my life is miserable life due to hormone treatment (eligard) want to quit asap . questions to ask ? /experiences ?
Im a very active 61 - had zero symptoms - no peeing in the night etc and 15 PSA was only flagged while doing pre op for a hip replacement in January. Next PSA was 17 in March so in for biopsy - 8 positive biopsy samples of 48 taken but only one of concern with Gleason of 8. PET scan indicated borderline
Im a very active 61 - had zero symptoms - no peeing in the night etc and 15 PSA was only flagged while doing pre op for a hip replacement in January. Next PSA was 17 in March so in for biopsy - 8 positive biopsy samples of 48 taken but only one of concern with Gleason of 8. PET scan indicated borderline
moon1878
in
Prostate Cancer Network
6 months ago
Wait or start docetaxel?
Currently taking Nubeqa and Orgovyx but PSA doubling time is only 7 weeks and PSMA scan shows activity in abdominal lymph nodes, 2 vertebrae and 2 ribs. MO suggested DORA Clinical trial (everyone gets docetaxel, half get radium) but the head of a trial I was previously in at NIH feels that unless a CT
Currently taking Nubeqa and Orgovyx but PSA doubling time is only 7 weeks and PSMA scan shows activity in abdominal lymph nodes, 2 vertebrae and 2 ribs. MO suggested DORA Clinical trial (everyone gets docetaxel, half get radium) but the head of a trial I was previously in at NIH feels that unless a CT
AllenMarco
in
Advanced Prostate Cancer
6 months ago
WHAT ARE THE CURRENT EFFECTIVE SALVAGE TREATMENTS IN CASE OF A REOCCURRENCE IF YOU HAVE HAD SBRT,IMRT, WITH PLACEMENT OF GOLD BARS?
It appears that if you had SBRT or like myself IMRT and you were given
gold markers
you cannot do any of the following
salvage treatments in case of a reoccurrence
: Proton therapy, Hifu, Tulsa Pro , Etc. Is this true???? Again a significant fact left out before treatment...
In addition
It appears that if you had SBRT or like myself IMRT and you were given
gold markers
you cannot do any of the following
salvage treatments in case of a reoccurrence
: Proton therapy, Hifu, Tulsa Pro , Etc. Is this true???? Again a significant fact left out before treatment...
In addition
JWS13
in
Advanced Prostate Cancer
6 months ago
I like it, but not too much: Phase 2 trial of a DNA vaccine (pTVG-HP) and nivolumab in patients with nmHSPC
"No patients met the primary endpoint of complete PSA response; however, 4/19 (21%) patients had a PSA decline >50%. Median PSA doubling times were 5.9 months pretreatment, 25.6 months on-treatment (p=0.001), and 9.0 months in the subsequent year off-treatment. The overall median radiographic progression-free
"No patients met the primary endpoint of complete PSA response; however, 4/19 (21%) patients had a PSA decline >50%. Median PSA doubling times were 5.9 months pretreatment, 25.6 months on-treatment (p=0.001), and 9.0 months in the subsequent year off-treatment. The overall median radiographic progression-free
Maxone73
in
Advanced Prostate Cancer
6 months ago
Ferritin and Haemoglobin levels
Hi All, my husband had to abandon radium 223 when it was discovered that he had several lung nodules (around 8mm). His PSA has been increasing for the last 18 months (he was diagnosed August 2022) so his oncologist sent him for a scan after the 4th radium infusion which is how the lung nodules were discovered
Hi All, my husband had to abandon radium 223 when it was discovered that he had several lung nodules (around 8mm). His PSA has been increasing for the last 18 months (he was diagnosed August 2022) so his oncologist sent him for a scan after the 4th radium infusion which is how the lung nodules were discovered
NLondon43
in
Advanced Prostate Cancer
9 days ago
Rising PSA
I had a prostatectomy almost 3 years ago. My PSA has been undetectable (<0.01) for all that time. This week it was .02 I’m going to redo the test to make sure. Then my urologist wants to refer me to a radiation oncologist. Has anyone had any experience with this. It’s really been hard trying to sort
I had a prostatectomy almost 3 years ago. My PSA has been undetectable (<0.01) for all that time. This week it was .02 I’m going to redo the test to make sure. Then my urologist wants to refer me to a radiation oncologist. Has anyone had any experience with this. It’s really been hard trying to sort
MJPH
in
Prostate Cancer And Gay Men
6 months ago
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