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Drug fails in Phase II trial for treating Parkinson's Disease - Exenatide (Byetta, Bydureon)
Evidence suggest that microglia are relevant to Parkinson's disease pathogenesis, therefore the recent clinical trial warranted exploration of trying to attenuate pathogenic microglial function. They sought to test the safety and efficacy of NLY01—a brain penetrant, pegylated, longer-lasting version
Evidence suggest that microglia are relevant to Parkinson's disease pathogenesis, therefore the recent clinical trial warranted exploration of trying to attenuate pathogenic microglial function. They sought to test the safety and efficacy of NLY01—a brain penetrant, pegylated, longer-lasting version
Baron1
in
Cure Parkinson's
6 months ago
Start of SCT journey
Quick recap for those that haven't followed my previous posts. Diagnosed September 2022 with primary MF, no previous signs or symptoms before catching Covid in June 2022 and health deteriorating until GP visit at end of August 2022. After some RBC transfusions, blood tests and BMP I enrolled on FEDORA
Quick recap for those that haven't followed my previous posts. Diagnosed September 2022 with primary MF, no previous signs or symptoms before catching Covid in June 2022 and health deteriorating until GP visit at end of August 2022. After some RBC transfusions, blood tests and BMP I enrolled on FEDORA
Flyingsteamer
in
MPN Voice
6 months ago
AFib and Blood Pressure
Is there a correlation or causation or no link between Afib and high blood pressure? I had sudden occurrence of persistent AF and high BP. My BP had always been well within the normal range. Thank you for any info you can provide. I know it will be thoughtful and I understand you are not physicians
Is there a correlation or causation or no link between Afib and high blood pressure? I had sudden occurrence of persistent AF and high BP. My BP had always been well within the normal range. Thank you for any info you can provide. I know it will be thoughtful and I understand you are not physicians
Cholla3
in
AF Association
11 months ago
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kardia
Hi, I had
atrial
flutter
treated successfully by ablation 2 years ago. I still take anti-coagulants and have been told that I could now stop these. I am worried about doing this, so my doctor is suggesting monitoring with a Kardia device for a few months and if all good, then stopping.
Hi, I had
atrial
flutter
treated successfully by ablation 2 years ago. I still take anti-coagulants and have been told that I could now stop these. I am worried about doing this, so my doctor is suggesting monitoring with a Kardia device for a few months and if all good, then stopping.
Easternmost
in
Arrhythmia Alliance
2 years ago
Vitamin D: Secondary Analysis of the VITAL Randomized Clinical Trial (with a surprise!)
I don't know if this was previously posted (it's from 2020)...but it's fascinating. In their first analysis the researchers did not take into consideration...fat https://pubmed.ncbi.nlm.nih.gov/33206192/ Ah the secondary analysis was done by the same researchers from the original study!
I don't know if this was previously posted (it's from 2020)...but it's fascinating. In their first analysis the researchers did not take into consideration...fat https://pubmed.ncbi.nlm.nih.gov/33206192/ Ah the secondary analysis was done by the same researchers from the original study!
Maxone73
in
Advanced Prostate Cancer
6 months ago
Not about advanced PCa, but might be useful: curcumin and BPH
The nano-micellar curcumin improves International Prostate Symptoms Score (IPSS) in patients with benign prostatic hyperplasia: a randomized clinical trial https://pubmed.ncbi.nlm.nih.gov/37458774/
The nano-micellar curcumin improves International Prostate Symptoms Score (IPSS) in patients with benign prostatic hyperplasia: a randomized clinical trial https://pubmed.ncbi.nlm.nih.gov/37458774/
Maxone73
in
Advanced Prostate Cancer
6 months ago
hu CAR-T 19 IL-18 4th Generation Clinical Trial 90 Day Check-up With All of My Favorite Tests
It's been a long time since I have received a MRD negative diagnosis, 13 years to be exact, after my FCR treatment. All of the other treatments didn't require a BMB to confirm a negative reading, I had a few remissions, but they were just on paper. My blood counts were good, and I felt fine, but a relapse
It's been a long time since I have received a MRD negative diagnosis, 13 years to be exact, after my FCR treatment. All of the other treatments didn't require a BMB to confirm a negative reading, I had a few remissions, but they were just on paper. My blood counts were good, and I felt fine, but a relapse
steve5441
in
CLL Support
6 months ago
Too much to take in!
A lot going on with no answers. Firstly having been diagnosed with AF in May, I had my fourth episode whilst in France a couple of weeks ago. Previous to that I was asked whether I would take part in the DOCCLA system which is an extension of a hospital ward apparently where they monitor you at home
A lot going on with no answers. Firstly having been diagnosed with AF in May, I had my fourth episode whilst in France a couple of weeks ago. Previous to that I was asked whether I would take part in the DOCCLA system which is an extension of a hospital ward apparently where they monitor you at home
Retired010
in
AF Association
11 months ago
Not about PCa, but worth checking...CRISPR in oncology phase 1-2
"A clinical trial to assess the safety and efficacy of genetically-engineered, neoantigen-specific Tumor Infiltrating Lymphocytes (TIL) in which the intracellular immune checkpoint CISH has been inhibited using CRISPR gene editing for the treatment of Gastro-Intestinal (GI) Cancer." https://www.clinicaltrials.gov
"A clinical trial to assess the safety and efficacy of genetically-engineered, neoantigen-specific Tumor Infiltrating Lymphocytes (TIL) in which the intracellular immune checkpoint CISH has been inhibited using CRISPR gene editing for the treatment of Gastro-Intestinal (GI) Cancer." https://www.clinicaltrials.gov
Maxone73
in
Advanced Prostate Cancer
6 months ago
How long to stay on blood thinners …and after ablation heart symptoms….
Good morning all, Since I haven’t heard from a doctor about blood thinners, how long should I stay on them after ablation? Thinking blanking period but I think here they said one month? After I eat dinner and walk the dog I start to get increases in heart rate (sitting down normally 60 but will be
Good morning all, Since I haven’t heard from a doctor about blood thinners, how long should I stay on them after ablation? Thinking blanking period but I think here they said one month? After I eat dinner and walk the dog I start to get increases in heart rate (sitting down normally 60 but will be
Chrissy7
in
Atrial Fibrillation Support
11 months ago
Do you or a member of your family been diagnosed with AF?
Atrial Fibrillation is the most common arrhythmia, affecting many individuals around the world, if you would like to find out more about the latest developments in the management of AF and
Atrial
Flutter
.
Atrial Fibrillation is the most common arrhythmia, affecting many individuals around the world, if you would like to find out more about the latest developments in the management of AF and
Atrial
Flutter
.
TracyAdmin
Partner
in
AF Association
2 years ago
Wait or start docetaxel?
Currently taking Nubeqa and Orgovyx but PSA doubling time is only 7 weeks and PSMA scan shows activity in abdominal lymph nodes, 2 vertebrae and 2 ribs. MO suggested DORA Clinical trial (everyone gets docetaxel, half get radium) but the head of a trial I was previously in at NIH feels that unless a CT
Currently taking Nubeqa and Orgovyx but PSA doubling time is only 7 weeks and PSMA scan shows activity in abdominal lymph nodes, 2 vertebrae and 2 ribs. MO suggested DORA Clinical trial (everyone gets docetaxel, half get radium) but the head of a trial I was previously in at NIH feels that unless a CT
AllenMarco
in
Advanced Prostate Cancer
6 months ago
Newly diagnosed AFib 40 year old
Hello everyone, last week I was diagnosed with persistent afib with lbbb and I'm terrified. I've been discharged with a bag of meds (bisoprolol, flecanide and rivaroxaban) and on the list for an ablation. I haven't been given much info and investigated everything myself. I just feel utterly depressed
Hello everyone, last week I was diagnosed with persistent afib with lbbb and I'm terrified. I've been discharged with a bag of meds (bisoprolol, flecanide and rivaroxaban) and on the list for an ablation. I haven't been given much info and investigated everything myself. I just feel utterly depressed
Harrgem
in
AF Association
11 months ago
Clinical trial: keep an eye on this
First results should be available by the first months of 2024. Radiation Medication (Radium-223 Dichloride) Versus Radium-223 Dichloride Plus Radiation Enhancing Medication (M3814) Versus Radium-223 Dichloride Plus M3814 Plus Avelumab (a Type of Immunotherapy) for Advanced Prostate Cancer Not Responsive
First results should be available by the first months of 2024. Radiation Medication (Radium-223 Dichloride) Versus Radium-223 Dichloride Plus Radiation Enhancing Medication (M3814) Versus Radium-223 Dichloride Plus M3814 Plus Avelumab (a Type of Immunotherapy) for Advanced Prostate Cancer Not Responsive
Maxone73
in
Advanced Prostate Cancer
6 months ago
After an AFib attack symptoms
I was diagnosed with AFib in October 2021 and am on an anticoagulant although I also take several medications for Hypertension including Bisoprol 15mg. Fortunately I have not had many AFib episodes although had one in the early hours of this morning.When I am having an AFib episode I find I need to pass
I was diagnosed with AFib in October 2021 and am on an anticoagulant although I also take several medications for Hypertension including Bisoprol 15mg. Fortunately I have not had many AFib episodes although had one in the early hours of this morning.When I am having an AFib episode I find I need to pass
Jomaur
in
Atrial Fibrillation Support
11 months ago
Researchers add to existing evidence that vitamin B3 may help slow down the progression of Parkinson'
https://www.parkinsons.org.uk/news/more-research-shows-potential-benefits-vitamin-b3-parkinsons A new phase 1 clinical trial, the NR-SAFE study, has published promising signs that taking a high dose of vitamin B3 is safe, and can reduce some symptoms for people with Parkinson’s.
https://www.parkinsons.org.uk/news/more-research-shows-potential-benefits-vitamin-b3-parkinsons A new phase 1 clinical trial, the NR-SAFE study, has published promising signs that taking a high dose of vitamin B3 is safe, and can reduce some symptoms for people with Parkinson’s.
CuriousMe12
in
Cure Parkinson's
6 months ago
Cancer causation -- inflammation and statistics
https://www.newyorker.com/magazine/2023/12/18/all-the-carcinogens-we-cannot-see Those of us whose cancer is quiet don't want to wake it up, but nobody knows for sure what to do (or not do). This article provides some food for thought and offers the opportunity for us to revisit our views about the
https://www.newyorker.com/magazine/2023/12/18/all-the-carcinogens-we-cannot-see Those of us whose cancer is quiet don't want to wake it up, but nobody knows for sure what to do (or not do). This article provides some food for thought and offers the opportunity for us to revisit our views about the
mistersafety
in
Advanced Prostate Cancer
6 months ago
I need some information and help
I am reaching out again to you wonderful people. Can you tell me if irregular heartbeat usually below 100, sometimes a bit over for five minutes is also atrial fibrillation. Are they the same thing I would like to understand - how this works. I have now had irregular heart beat that I can feel
I am reaching out again to you wonderful people. Can you tell me if irregular heartbeat usually below 100, sometimes a bit over for five minutes is also atrial fibrillation. Are they the same thing I would like to understand - how this works. I have now had irregular heart beat that I can feel
kitttycat
in
AF Association
11 months ago
Blood Thinners for RSL Sufferers
hi Rls friends, I have managed to withdraw from Pramipexole and have been taking Targinact 4.5/ naloxone Successfully for several months However, I have been admitted to hospital with a stroke and finding that I am dispairat this point( after 2 weeks) My usual Targinate has been replaced with a
hi Rls friends, I have managed to withdraw from Pramipexole and have been taking Targinact 4.5/ naloxone Successfully for several months However, I have been admitted to hospital with a stroke and finding that I am dispairat this point( after 2 weeks) My usual Targinate has been replaced with a
Jose651
in
Restless Legs Syndrome
11 months ago
Terrible nights when in afib
Hi everyone, I posted yesterday about stress and afib episodes. I now have another question."Do any of you have bad night's sleep when in afib, constant wakening, sweating etc?" If so any advice would be welcome. I am still in afib since the early hours of Saturday morning but much slower, feel tired
Hi everyone, I posted yesterday about stress and afib episodes. I now have another question."Do any of you have bad night's sleep when in afib, constant wakening, sweating etc?" If so any advice would be welcome. I am still in afib since the early hours of Saturday morning but much slower, feel tired
Karendeena
in
AF Association
11 months ago
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