Blue rock therapeutic clinical trials

[Prakash1]

has anyone participated in this and what is your experience

[gomelgo]

What are they trialing?

[Boscoejean in reply to gomelgo]

bluerocktx.com/bluerocks-ph...

[gomelgo in reply to Boscoejean]

Thank you! Looks like this is an injection into the brain. Is that right?

[Boscoejean in reply to gomelgo]

"About bemdaneprocel (BRT-DA01) and the Phase I Trial

Bemdaneprocel (BRT-DA01) is an investigational cell therapy designed to replace the dopamine producing neurons that are lost in Parkinson’s disease. These dopaminergic neuron precursors are derived from pluripotent stem cells (PSC) that are human embryonic stem cells. In a surgical procedure, these neuron precursors are implanted into the brain of a person with Parkinson’s disease. When transplanted, they have the potential to reform neural networks that have been severely affected by Parkinson’s and restore motor and non-motor function to patients."

"This phase I study is a multi-center, multi-site, open-label, non-randomized, non-controlled study. Twelve (12) subjects received surgical transplantation of 1 of 2 different dose levels of bemdaneprocel cells to the post-commissural putamen bilaterally, and administration of a 1-year immunosuppression regimen. Cohort A (5 subjects) received a dose of 0.9 million cells per putamen. Cohort B (7 subjects) received 2.7 million cells per putamen. Safety and tolerability were assessed at 1 year, along with evidence of cell survival and motor effects. The feasibility of transplantation was also assessed. All assessments will continue over 2 years."

I have been trying to find more information on the surgical implantation but so far I have not found a description of exactly how it is done.

[gomelgo in reply to Boscoejean]

It's too bad they aren't very forthright about their method.