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tp53 mutation
Hi All, my dad has been diagnosed with CLL and has just had it confirmed that he has the TP53 mutation/deletion. He is stable at the moment and is currently on watch & wait. His consultant has said if and when he starts treatment it will be for life or until it isn’t effective. I’ve read lots that say
Hi All, my dad has been diagnosed with CLL and has just had it confirmed that he has the TP53 mutation/deletion. He is stable at the moment and is currently on watch & wait. His consultant has said if and when he starts treatment it will be for life or until it isn’t effective. I’ve read lots that say
Fortheloveoffarming
in
CLL Support
3 months ago
liquid biopsy lung cancer
Hello everyone, Does anyone have experience of a liquid biopsy either via the NHS or privately? We got a second opinion, discussed the case with a professor who recommended a guardant 360 liquid biopsy due to the unusual spread into the other lung & appearance during biopsy which is apparently usually
Hello everyone, Does anyone have experience of a liquid biopsy either via the NHS or privately? We got a second opinion, discussed the case with a professor who recommended a guardant 360 liquid biopsy due to the unusual spread into the other lung & appearance during biopsy which is apparently usually
Clark74517796
in
The Roy Castle Lung Cancer Foundation
3 months ago
Different mutation?
I was just checking via my NHS app what had been sent to my GP, when I noticed on a letter from Guys this - it listed my mutations - CGN - normal karotype, NGS - CALR, L2AF1, ASXL2. (High risk markers) Previously I thought I was ASXL1, it could be a typo I suppose but does anyone know the difference
I was just checking via my NHS app what had been sent to my GP, when I noticed on a letter from Guys this - it listed my mutations - CGN - normal karotype, NGS - CALR, L2AF1, ASXL2. (High risk markers) Previously I thought I was ASXL1, it could be a typo I suppose but does anyone know the difference
lizzziep
in
MPN Voice
3 months ago
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Starting T3 - advice please
I am fortunate to have been allowed a trial of T3 through the NHS (in Scotland) Can I ask for some advice / could anyone link to some helpful posts around starting T3? I am currently on 100mcg Levo. This is being reduced to 50mcg with 5mcg of Liothyronine twice a day (12 hours apart - so 7:30am and
I am fortunate to have been allowed a trial of T3 through the NHS (in Scotland) Can I ask for some advice / could anyone link to some helpful posts around starting T3? I am currently on 100mcg Levo. This is being reduced to 50mcg with 5mcg of Liothyronine twice a day (12 hours apart - so 7:30am and
GW1000
in
Thyroid UK
1 month ago
What's the link for prescribing data?
I've lost where I saved it. I'd like to search my surgery for whether they prescribe T3 and I cant find it. Would someone kindly share the link please? :D Thank you
I've lost where I saved it. I'd like to search my surgery for whether they prescribe T3 and I cant find it. Would someone kindly share the link please? :D Thank you
WitchingHour2point0
in
Thyroid UK
5 months ago
EXERCISE is our best med.
I wrote this in response to a post that seems to have disappeared This is one of the most important post topics on this board. [i] In another large, phase 3 clinical trial funded by Movember, Chan and epidemiologists Stacey Kenfield and Lorelei Mucci, with principal investigators Rob Newton and
I wrote this in response to a post that seems to have disappeared This is one of the most important post topics on this board. [i] In another large, phase 3 clinical trial funded by Movember, Chan and epidemiologists Stacey Kenfield and Lorelei Mucci, with principal investigators Rob Newton and
Scout4answers
in
Advanced Prostate Cancer
3 months ago
Suspected ulcerative colitis and nausea
Hi all hope all is wellI have been suffering with suspected ulcerative colitis for a while now and have lately started to feel nauseous and not wanting to eat much especially in the morning. I go dizzy alot too and have daily urgency to pass BM every morning most times quite soft with blood. I eat only
Hi all hope all is wellI have been suffering with suspected ulcerative colitis for a while now and have lately started to feel nauseous and not wanting to eat much especially in the morning. I go dizzy alot too and have daily urgency to pass BM every morning most times quite soft with blood. I eat only
Sooty712
in
Crohn's and Colitis Support
12 days ago
feel awful
just over 2 weeks ago went diwn to 2 mg prednisolone from 50 in august 2022. Nothing seems to be going right now. After many many years of 75 mg thyroxine daily for under active thyroid was told to cut down to 50 mg daily. Also became diabetic with Pred. & have been taking 2 500 mg metformin daily
just over 2 weeks ago went diwn to 2 mg prednisolone from 50 in august 2022. Nothing seems to be going right now. After many many years of 75 mg thyroxine daily for under active thyroid was told to cut down to 50 mg daily. Also became diabetic with Pred. & have been taking 2 500 mg metformin daily
CavalierKC3
in
PMRGCAuk
5 months ago
advice needed please re iron and thyroxine
hi there, I’d really appreciate some advice. I’ve been on Thyroxine for a number of years and have been fine, I’ve just been told that I have Anaemia and have started on Ferrous Fumarate tabs 210 mg. I’ve started to feel tearful and anxious this last week and wonder if the iron is affecting my thyroid
hi there, I’d really appreciate some advice. I’ve been on Thyroxine for a number of years and have been fine, I’ve just been told that I have Anaemia and have started on Ferrous Fumarate tabs 210 mg. I’ve started to feel tearful and anxious this last week and wonder if the iron is affecting my thyroid
Poppyqueen
in
Thyroid UK
5 months ago
Why has my ferritin risen so quickly!?
So I got my yearly iron panel check, and my ferritin had dropped to 42! even though I eat iron rich foods and take vitamin C with meals! All my vitamin levels are now optimal I take an expensive powder form of probiotic by Biomel and the Rheal gut feel greens powder, all supporting my gut health and
So I got my yearly iron panel check, and my ferritin had dropped to 42! even though I eat iron rich foods and take vitamin C with meals! All my vitamin levels are now optimal I take an expensive powder form of probiotic by Biomel and the Rheal gut feel greens powder, all supporting my gut health and
ThyroidObsessed
in
Thyroid UK
13 days ago
Recently diagnosed and trying to work out what to do! All advice gratefully received.
I was diagnosed this week. Still in shock a bit as I am a fit and very active 58 with no real symptoms. I have a psa of 7.7. Gleason Score 3+4 = 7 one in 10 cores with a 2.5mm tumour length whoich is 20% of the core involved. 30% of cores showed cribreform pattern 4 glands. Area of concern on MRIs
I was diagnosed this week. Still in shock a bit as I am a fit and very active 58 with no real symptoms. I have a psa of 7.7. Gleason Score 3+4 = 7 one in 10 cores with a 2.5mm tumour length whoich is 20% of the core involved. 30% of cores showed cribreform pattern 4 glands. Area of concern on MRIs
welshsky
in
Prostate Cancer Network
3 months ago
peeling fingertips
does anyone else suffer with peeling fingers and are on thyroxine replacement
does anyone else suffer with peeling fingers and are on thyroxine replacement
Helenfeb
in
Thyroid UK
5 months ago
Always hit pca hard especially in the beginning and follow your instincts, You are Your Own Best Advocate.
Update Husband fighting with Stage 4 pca 06/2022 3 lytic lesions Seen same Medical Oncologist since 07/2022 Received a call from PA after only in this fight for 1.8 years and my husband has liver metastaties We don’t know how many or how big, as MO has not released pet scan of course we are devastated
Update Husband fighting with Stage 4 pca 06/2022 3 lytic lesions Seen same Medical Oncologist since 07/2022 Received a call from PA after only in this fight for 1.8 years and my husband has liver metastaties We don’t know how many or how big, as MO has not released pet scan of course we are devastated
Shorehousejam
in
Advanced Prostate Cancer
3 months ago
Today was a good day
My husband had his PSMA scan today and it was negative for mets!! I am so relieved! He also had his PSA tested today and no change since December. I feel like I can breathe for a moment. We also met with the radiation oncologist this morning to discuss brachytherapy boost and it was a very positive meeting
My husband had his PSMA scan today and it was negative for mets!! I am so relieved! He also had his PSA tested today and no change since December. I feel like I can breathe for a moment. We also met with the radiation oncologist this morning to discuss brachytherapy boost and it was a very positive meeting
EvFC
in
Advanced Prostate Cancer
3 months ago
Just some new Information about AI
Came across this article a couple days ago. https://www.news-medical.net/news/20210924/Researchers-identify-two-subtypes-of-metastatic-prostate-cancer.aspx#:~:text=Building%20off%20of%20earlier%20studies%20that%20discovered%20clinically,into%20two%20types%20known%20as%20luminal%20and%20basal AI has
Came across this article a couple days ago. https://www.news-medical.net/news/20210924/Researchers-identify-two-subtypes-of-metastatic-prostate-cancer.aspx#:~:text=Building%20off%20of%20earlier%20studies%20that%20discovered%20clinically,into%20two%20types%20known%20as%20luminal%20and%20basal AI has
chefjlu
in
Advanced Prostate Cancer
5 months ago
IBS or something more?
Hi, this is my first post on here, and I'm just wondering if anyone can calm my anxiety and mind...For the past 4 years, I've had what I can only call unusual symptoms...bloating, passing a lot of blood from my back passage (clots included and the amount I'd pass during a heavy period), a lot of mucus
Hi, this is my first post on here, and I'm just wondering if anyone can calm my anxiety and mind...For the past 4 years, I've had what I can only call unusual symptoms...bloating, passing a lot of blood from my back passage (clots included and the amount I'd pass during a heavy period), a lot of mucus
SES05
in
IBS Network
15 days ago
Advice on raising NDT
Following on from my post on 26/02/24, my symptoms got worse (increased number of anxiety attacks and unable to cope with pain in head/neck and upper back) and the GP didn't have any ideas, so I saw a thyroid specialist recommended by thyroid UK in April. The doctor had my blood tests done and these
Following on from my post on 26/02/24, my symptoms got worse (increased number of anxiety attacks and unable to cope with pain in head/neck and upper back) and the GP didn't have any ideas, so I saw a thyroid specialist recommended by thyroid UK in April. The doctor had my blood tests done and these
SarrahMay
in
Thyroid UK
2 months ago
Recent medichecks results
Wow! Did medichecks test and for the first time in all the time I’ve been testing my TGAb were in normal range (110 with range under 115). TPOAb within range as usual. TSH is still suppressed (no surprise) CRP is .983 despite me having been a bit under the weather recently and recovering from a broken
Wow! Did medichecks test and for the first time in all the time I’ve been testing my TGAb were in normal range (110 with range under 115). TPOAb within range as usual. TSH is still suppressed (no surprise) CRP is .983 despite me having been a bit under the weather recently and recovering from a broken
Mickeydooley
in
Thyroid UK
1 month ago
better delivery for better results: nanolipid particles work well in vivo
”Mitchell and postdoctoral fellow Lulu Xue were able to achieve therapeutic mRNA delivery into the lungs, helping to eradicate metastatic lung cancer in preclinical mouse model studies. ” https://www.thedp.com/article/2024/04/penn-lipid-nanoparticles-michael-mitchell-research
”Mitchell and postdoctoral fellow Lulu Xue were able to achieve therapeutic mRNA delivery into the lungs, helping to eradicate metastatic lung cancer in preclinical mouse model studies. ” https://www.thedp.com/article/2024/04/penn-lipid-nanoparticles-michael-mitchell-research
Maxone73
in
Advanced Prostate Cancer
3 months ago
Pregnancy test line progression?
Hi, We are on our 6th round of ivf. Second transfer - frozen hatching embryo. We started testing day 4 (evening) and it is now day 6. We took ovidrel 250 13 days ago- could this line be the trigger? We are also wondering if its chemical as it came up early and we are paranoid it is slightly fading
Hi, We are on our 6th round of ivf. Second transfer - frozen hatching embryo. We started testing day 4 (evening) and it is now day 6. We took ovidrel 250 13 days ago- could this line be the trigger? We are also wondering if its chemical as it came up early and we are paranoid it is slightly fading
SD5117
in
Fertility Network UK
5 months ago
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