Experiences with

Alemtuzumab

The last two days I also had Alemtuzumab to reduce my T cells and help the donated stem cells engraft. I coped with the chemo pretty well, no nausea or sickness at all and I felt really well.

Monday the six days of chemo starts, intravenous fludarbine, Melphalan with Alemtuzumab to reduce my T cells. On the 7th day I get my new stem cells and then the waiting starts.

Front Cell Neurosci. 2019; 13: 107. Published online 2019 Mar 19. doi: 10.3389/fncel.2019.00107 Antiphospholipid Antibodies Overlapping in Isolated Neurological Syndrome and Multiple Sclerosis: Neurobiological Insights and Diagnostic Challenges Chiara D’Angelo,1,2,3 Oriol Franch,4 Lidia

Some MS therapies, including steroids and disease-modifying therapies like Lemtrada (alemtuzumab), Tysabri (natalizumab), and Gilenya (fingolimod), are associated with diminished effectiveness of vaccines and a risk of infection as well.

Hi Has anyone been treated with the above medication (I have given both names for it). If you have how was it?and did it work for you? I think I am running out of drug options/ combinations now, and platelets remain at 0. This is the doctors next plan but the hospital have only ever treated 3 people

Hi Realise this is very specific but know from here and was also told on G2 (Infusion bay at Addenbrookes - formally PSSU) that there are a couple of other teachers out there whose Behcet's has been tackled with campath. I would love to link up. I've just finished my fourth course of campath yesterday

Question from the face book group if anyone can help Just wondering if anybody has had - Alemtuzumab Dr David Jayne has put me forwards for it. I have to wait until June, 6 months clear of Rituximab but hopefully I will finally be able to get things under control with this new one...

Martin Lockwood treated me with a drug then called Campath, (Alemtuzumab) at Addenbrooke’s Hospital Cambridge. I was suffering with Wegener’s Granulomatosis. Since then the Vasculitis Clinic at Addenbrooke’s now headed by Dr.

Coles, the first author of two papers describing phase 3 trials of alemtuzumab for Multiple Sclerosis.)

Lemtrada is another name for Alemtuzumab. This is the Wiki article on it: http://en.wikipedia.org/wiki/Alemtuzumab Rod Image is taken from Wiki article.

Alemtuzumab consolidation did not provide benefit over similar regimens without alemtuzumab, irrespective of age." Neil

Irradiated blood components should be used after alemtuzumab (anti-CD52) therapy. Their use after rituximab (anti-CD20) is not recommended at this time.

Alemtuzumab, aka Campath, ,consolidation therapy after chemotherapy or chemoimmunotherapy does not improve progression-free or overall survival in either younger or older patients.' Article...

VUK also play an active role in the UK Vasculitis Rare Disease Working Group In terms of current research funding, VUK are supporting trials at Addenbrookes Hospital, Cambridge of a new drug for the treatment of vasculitis, Alemtuzumab as well as a project at Birmingham Wellcome Trust Clinical Research

Dr David Jayne's team led by Dr Rona Smith at Addenbrookes are undertaking research into an existing drug, Alemtuzumab, to see if it proves to be effective in treating ANCA related vasculitis. Alemtuzumab, which is one of the new generation of monoclonal antibodies, like Rituximab.

We have received an email today asking about Campath. This lady is about to start a course of treatment and is obviously very concerned.