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Experiences with
Androgen deprivation therapy (ADT)
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Is Pluvicto worth pursuing?
Started
ADT
with Firmagon April, 2021, and Xtandi May, 2021. Didn't tolerate
ADT
well with extreme fatigue, weight loss, muscle loss, food tastes bad, chronic sinus inflammation.
Started
ADT
with Firmagon April, 2021, and Xtandi May, 2021. Didn't tolerate
ADT
well with extreme fatigue, weight loss, muscle loss, food tastes bad, chronic sinus inflammation.
Battle_on
in
Advanced Prostate Cancer
2 years ago
Lack of NDT?
Hi there, a couple of ladies I know who are prescribed NDT are being told that there's none available. Does anyone know if this is a nationwide problem and if it is, why this is happening? Thank you, Julie
Hi there, a couple of ladies I know who are prescribed NDT are being told that there's none available. Does anyone know if this is a nationwide problem and if it is, why this is happening? Thank you, Julie
juliej333
in
Thyroid UK
10 months ago
Osteoporosis risk with suppressed TSH
Many of the endocrinologist I've encountered seem to be vexed with borderline sociopathy, lurking beneath grimacing, slightly tolerant demeanors. However, the last one seemed to be merely friendly and inept. Recent communication from current specialist: "Having a low TSH can increase your risk for heart
Many of the endocrinologist I've encountered seem to be vexed with borderline sociopathy, lurking beneath grimacing, slightly tolerant demeanors. However, the last one seemed to be merely friendly and inept. Recent communication from current specialist: "Having a low TSH can increase your risk for heart
RockyPath
in
Thyroid UK
10 months ago
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The Lancet - Treatment options for metastatic hormone-sensitive prostate cancer - Comment by Louise Kostos & Declan G Murphy, Pub: 09/05/22
In this Lancet comment article by Louise Kostos & Declan Murphy, both at PeterMac in AU, they update the current treatment options/recommendations for metastatic, hormone-sensitive PCa in light of the Phase III results from the CHART trial comparing
ADT
plus the new ARI agent rezvilutamide vs
ADT
plus
In this Lancet comment article by Louise Kostos & Declan Murphy, both at PeterMac in AU, they update the current treatment options/recommendations for metastatic, hormone-sensitive PCa in light of the Phase III results from the CHART trial comparing
ADT
plus the new ARI agent rezvilutamide vs
ADT
plus
cujoe
in
Fight Prostate Cancer
2 years ago
NDT dosing confusion, how to make it work?
Hi All, Trying to understand the NDT dosing and if it's working for me. They say 1 grain of Erfa is about 100 McG of levo. However, 1 grain only gives you 38 McG of T4. So if I was on 88 McG of levo before NDT and I now take 1 grain of NDT instead, I only get 38 McG of T4? How does the 1 grain equals
Hi All, Trying to understand the NDT dosing and if it's working for me. They say 1 grain of Erfa is about 100 McG of levo. However, 1 grain only gives you 38 McG of T4. So if I was on 88 McG of levo before NDT and I now take 1 grain of NDT instead, I only get 38 McG of T4? How does the 1 grain equals
Juliet_22
in
Thyroid UK
10 months ago
Am I a poor converter?
I've just had my latest blood test results after starting 50mg Levothyroxine 6 weeks ago:TSH 1.65 (0.27-4.2) FT4 15.9 (12-22) 39% through range FT3 3.4 (3.1-6.8) 8% through range FT4:FT3 ratio is therefore 4.7. Just before starting Levothyroxine, my results were: TSH 5.88 FT4 12 FT3 3.44 FT4:FT3
I've just had my latest blood test results after starting 50mg Levothyroxine 6 weeks ago:TSH 1.65 (0.27-4.2) FT4 15.9 (12-22) 39% through range FT3 3.4 (3.1-6.8) 8% through range FT4:FT3 ratio is therefore 4.7. Just before starting Levothyroxine, my results were: TSH 5.88 FT4 12 FT3 3.44 FT4:FT3
Schilddruse
in
Thyroid UK
10 months ago
Mum with CBD
Good morning It's been a while since I wrote on here. My mum got diagnosed with CBD in 2017 we were told in January 2020 she had 4 weeks left to live and was moved into a care home for palliative care. Thankfully she is still with us. Hasn't eaten and been bed bound now for 4 years. She survives on 6
Good morning It's been a while since I wrote on here. My mum got diagnosed with CBD in 2017 we were told in January 2020 she had 4 weeks left to live and was moved into a care home for palliative care. Thankfully she is still with us. Hasn't eaten and been bed bound now for 4 years. She survives on 6
Bobbiejo21
in
PSP Association
9 months ago
Low Testosterone Linked to Hospitalization for COVID - By Kristen Monaco, Staff Writer, MedPage Today, September 2, 2022
[/i] If this is applicable to those PCa patients on
ADT
, then we can add one more major SE to the many already on the list for SOC
ADT
. Surely, someday in the distant future
ADT
will be looked upon as a near-medieval treatment to extend the lives on men with PCa.
[/i] If this is applicable to those PCa patients on
ADT
, then we can add one more major SE to the many already on the list for SOC
ADT
. Surely, someday in the distant future
ADT
will be looked upon as a near-medieval treatment to extend the lives on men with PCa.
cujoe
in
Fight Prostate Cancer
2 years ago
Vit B12 extremely high
About 5% of people have this at age 60, though few know. 1%/year move on to multiple myeloma, which (interestingly) has rather similar symptoms to prostate cancer and
ADT
. My numbers aren't too high so this probably is not an issue.
About 5% of people have this at age 60, though few know. 1%/year move on to multiple myeloma, which (interestingly) has rather similar symptoms to prostate cancer and
ADT
. My numbers aren't too high so this probably is not an issue.
rsgdmd
in
Advanced Prostate Cancer
2 years ago
PSA hovering around 1 even after a year on ADT + Enza, should we insist on Triplet Therapy ?
Hi All, My Father was diagnosed with Advanced PCa with extensive bone mets but no visceral spread last November. His PSA at dx was 325 and Gleason was 4+5 with all cores positive. His treatment started off with 10 sessions of Palliative RT followed by combination of Degarelix + Enzaluatmide + Denosumab
Hi All, My Father was diagnosed with Advanced PCa with extensive bone mets but no visceral spread last November. His PSA at dx was 325 and Gleason was 4+5 with all cores positive. His treatment started off with 10 sessions of Palliative RT followed by combination of Degarelix + Enzaluatmide + Denosumab
dudubaya
in
Advanced Prostate Cancer
1 year ago
one final chance of survival
hi, Yesterday I posted an update about my mum and her icu journey. I have a further update I would like to share. From her ct the original infection is finally clearing up. She has a lot of fluid around her lungs and pneumonia at the bottom that the antibiotics are not clearing. They said the chance
hi, Yesterday I posted an update about my mum and her icu journey. I have a further update I would like to share. From her ct the original infection is finally clearing up. She has a lot of fluid around her lungs and pneumonia at the bottom that the antibiotics are not clearing. They said the chance
Westbeginners1
in
ICUsteps
9 months ago
Recurrence after radiation.
I was on Eligard IN 2017 for 6 months and hated the side effects do
ADT
.
I was on Eligard IN 2017 for 6 months and hated the side effects do
ADT
.
Yacky
in
Prostate Cancer Network
2 years ago
Converting NDT and T3 to combo
I am currently on 20 mcg T3 and 150 mcg Thyroid—S daily. I have always bought my own medication as I didn't think I would manage to get T3 on NHS. I have just received a message to say they will give it to me so I'm over the moon. They also want me to ditch the Thyroid-S and replace with 100mcg Levo.
I am currently on 20 mcg T3 and 150 mcg Thyroid—S daily. I have always bought my own medication as I didn't think I would manage to get T3 on NHS. I have just received a message to say they will give it to me so I'm over the moon. They also want me to ditch the Thyroid-S and replace with 100mcg Levo.
carolinegodlonton
in
Thyroid UK
10 months ago
L/T vs S/T ADT post SRT & WPLNs?
RO seems to think pre
ADT
of 16 months with 2 months post, and low volume disease on PET scan with intermediate Decipher suggests that is enough hormone therapy. I see MO Monday. Any recommendations on length of
ADT
post SRT very much appreciated, thank you.
RO seems to think pre
ADT
of 16 months with 2 months post, and low volume disease on PET scan with intermediate Decipher suggests that is enough hormone therapy. I see MO Monday. Any recommendations on length of
ADT
post SRT very much appreciated, thank you.
jjpeabody
in
Advanced Prostate Cancer
2 years ago
EXTEND - Addition of Metastasis-Directed Therapy to Intermittent Hormone Therapy for Oligometastatic Prostate Cancer
The results of the EXTEND [EXTernal beam radiation to Eliminate Nominal metastatic Disease] Phase II Trial were published in JAMA Oncology this month [1]. {However, many will have seen the results, as presented at ASTRO 2022, & posted by Fish, 6 months ago [2].}
Results
"The study included
The results of the EXTEND [EXTernal beam radiation to Eliminate Nominal metastatic Disease] Phase II Trial were published in JAMA Oncology this month [1]. {However, many will have seen the results, as presented at ASTRO 2022, & posted by Fish, 6 months ago [2].}
Results
"The study included
pjoshea13
in
Fight Prostate Cancer
1 year ago
High TSH on high NDT dose
Hey, I'm feeling so confused. Any advice appreciated! I have used Thyrogold (NDT) to successfully treat my underactive thyroid (Hypothyroid with Hashimotos) for the last few years. Occasionally my dose needs altering slightly but generally it has remained stable on this medication. I am currently taking
Hey, I'm feeling so confused. Any advice appreciated! I have used Thyrogold (NDT) to successfully treat my underactive thyroid (Hypothyroid with Hashimotos) for the last few years. Occasionally my dose needs altering slightly but generally it has remained stable on this medication. I am currently taking
SunshineSaff
in
Thyroid UK
10 months ago
Frustrated at endo's obsession with TSH when other results point in the opposite direction
I hope this isn't going to take too long to explain. And this is really a frustrated rant about the obsession with TSH. I went to see a private endo, as my hypo symptoms had not resolved on a daily dose of 150mcg T4 and a split dose of 40mcg T3, given to me by an NHS endo who was prepared to accept
I hope this isn't going to take too long to explain. And this is really a frustrated rant about the obsession with TSH. I went to see a private endo, as my hypo symptoms had not resolved on a daily dose of 150mcg T4 and a split dose of 40mcg T3, given to me by an NHS endo who was prepared to accept
Reefseeker
in
Thyroid UK
10 months ago
Strategies to Re-Sensitize Castration-Resistant Prostate Cancer to Antiandrogen Therapy
University Hospital Virgen del Rocío, 41013 Seville, Spain.PMID: 37189723 DOI: 10.3390/biomedicines11041105
Abstract
Since prostate cancer (PCa) was described as androgen-dependent, the androgen receptor (AR) has become the mainstay of its systemic treatment: androgen deprivation therapy (
ADT
University Hospital Virgen del Rocío, 41013 Seville, Spain.PMID: 37189723 DOI: 10.3390/biomedicines11041105
Abstract
Since prostate cancer (PCa) was described as androgen-dependent, the androgen receptor (AR) has become the mainstay of its systemic treatment: androgen deprivation therapy (
ADT
pca2004
in
Fight Prostate Cancer
1 year ago
High cortisol
Hello again, So I finally did a 4 point saliva cortisol test and morning cortisol is high , how do I lowe this ? Could this be why im not tolerating my t3 in the ndt ?
Hello again, So I finally did a 4 point saliva cortisol test and morning cortisol is high , how do I lowe this ? Could this be why im not tolerating my t3 in the ndt ?
Rhannii7
in
Thyroid UK
10 months ago
actual castration instead of ADT
I am told I will be on these or some form of
ADT
for the rest of my life. Since the goal is to eliminate testosterone wouldn’t it make sense to remove the source of it? By doing so one could avoid all the nasty inevitable side effects. Thoughts?
I am told I will be on these or some form of
ADT
for the rest of my life. Since the goal is to eliminate testosterone wouldn’t it make sense to remove the source of it? By doing so one could avoid all the nasty inevitable side effects. Thoughts?
OldGuysRule
in
Advanced Prostate Cancer
2 years ago
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