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Abiraterone
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Is my Testosterone high?
(Lupron 6 mon shots,
Abiraterone
, & prednisone) Was switched to Eligard on Monday. Bloodwork Monday showed PSA undetectable and testosterone at 51 ng/dL. Is the testosterone high for being on ADT??
(Lupron 6 mon shots,
Abiraterone
, & prednisone) Was switched to Eligard on Monday. Bloodwork Monday showed PSA undetectable and testosterone at 51 ng/dL. Is the testosterone high for being on ADT??
Dlanghorne
in
Advanced Prostate Cancer
3 years ago
Venous thromboembolism in metastatic castration-resistant cancer patients
"These results first suggest that baseline ptDNA fraction in mCRPC patients treated with
abiraterone
or enzalutamide may be associated with increased VTE risk.
"These results first suggest that baseline ptDNA fraction in mCRPC patients treated with
abiraterone
or enzalutamide may be associated with increased VTE risk.
pjoshea13
in
Advanced Prostate Cancer
3 years ago
Neuroendocrine Prostate Cancer [NEPC]
By contrast, [i]multiple studies suggest that t-NEPC arises from adenocarcinomas as a consequence of an adaptive response to therapy, and the incidence of t-NEPC has been increasing due to the wide use of potent androgen receptor targeted agents (ARTAs), such as enzalutamide,
abiraterone
acetate, apalutamide
By contrast, [i]multiple studies suggest that t-NEPC arises from adenocarcinomas as a consequence of an adaptive response to therapy, and the incidence of t-NEPC has been increasing due to the wide use of potent androgen receptor targeted agents (ARTAs), such as enzalutamide,
abiraterone
acetate, apalutamide
pjoshea13
in
Advanced Prostate Cancer
3 years ago
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Two years Results
Treatments: 1)Lupron shot every 3 months effective December 2019. 2)Radiation to Pelvic for 4 weeks February 2020 3)
Abiraterone
250 mg with a low-fat breakfast + Prednisone 5 mg every day effective January 2020 Results: 04/14/20 PSA<0.03, 06/09/20 PSA<0.03, 07/31/20 PSA<0.03 & 09/30/20 PSA<0.03, 12
Treatments: 1)Lupron shot every 3 months effective December 2019. 2)Radiation to Pelvic for 4 weeks February 2020 3)
Abiraterone
250 mg with a low-fat breakfast + Prednisone 5 mg every day effective January 2020 Results: 04/14/20 PSA<0.03, 06/09/20 PSA<0.03, 07/31/20 PSA<0.03 & 09/30/20 PSA<0.03, 12
Pheart2
in
Advanced Prostate Cancer
3 years ago
Dasatinib
From 2019 [7]: "
Randomized Phase II Trial of
Alone or With Dasatinib in Men With Metastatic Castration-resistant Prostate Cancer (mCRPC)" "The Src family kinases have a proven role in tumorigenesis and in progression of various solid tumors, reviewed by Summy et al.19 Interactions
From 2019 [7]: "
Randomized Phase II Trial of
Alone or With Dasatinib in Men With Metastatic Castration-resistant Prostate Cancer (mCRPC)" "The Src family kinases have a proven role in tumorigenesis and in progression of various solid tumors, reviewed by Summy et al.19 Interactions
pjoshea13
in
Advanced Prostate Cancer
3 years ago
Any thoughts on why PSA rising but mets status stable?
I am writing for my dad who was diagnosed with PCa in 2010, after using ADT,
Abiraterone
, Olaprib, Provenge(Car-T) and now his PSA is about 5.2, with 5 mets on lliac and neck lymphatic.
I am writing for my dad who was diagnosed with PCa in 2010, after using ADT,
Abiraterone
, Olaprib, Provenge(Car-T) and now his PSA is about 5.2, with 5 mets on lliac and neck lymphatic.
MacWong
in
Advanced Prostate Cancer
3 years ago
New Member Scouting for answers; To radiate now or not
Plan they have mapped out at is to take Lupron and
Abiraterone
for 2 years and radiate prostate bed and two lymph nodes for 28 sessions starting soon after starting
Abiraterone
.
Plan they have mapped out at is to take Lupron and
Abiraterone
for 2 years and radiate prostate bed and two lymph nodes for 28 sessions starting soon after starting
Abiraterone
.
Scout4answers
in
Advanced Prostate Cancer
3 years ago
Lynparza (olaparib) +Zytiga (abiraterone) better than Zytiga alone for mCRPC regardless of BRCA status
The surprise is that Lynparza works so well in combination with
abiraterone
. It has been previously found to not work well as a single agent unless there is a BRCA mutation.
The surprise is that Lynparza works so well in combination with
abiraterone
. It has been previously found to not work well as a single agent unless there is a BRCA mutation.
Tall_Allen
in
Advanced Prostate Cancer
3 years ago
Having pain even psa is low
Start zytiga
abiraterone
in 4 Nov 2020, condition have been stable and psa been low in last few months. In july his psa is <0.03, but today he having more serious pain at his back and pelvis area is this normal?
Start zytiga
abiraterone
in 4 Nov 2020, condition have been stable and psa been low in last few months. In july his psa is <0.03, but today he having more serious pain at his back and pelvis area is this normal?
worrywaffle
in
Advanced Prostate Cancer
3 years ago
Just put diagnosis on profile.
It’s a shame
abiraterone
wasn’t accepted as first line treatment. Please see profile for diagnosis. I hope by the time his cancer becomes resistant to hormone therapy there will be yet more amazing treatments available.
It’s a shame
abiraterone
wasn’t accepted as first line treatment. Please see profile for diagnosis. I hope by the time his cancer becomes resistant to hormone therapy there will be yet more amazing treatments available.
Jordanh97
in
Advanced Prostate Cancer
3 years ago
PEACE1 - the advantage of combining docetaxel and abiraterone in men newly diagnosed with high volume metastatic PCA (update)
I promised I'd update this as more info came in. The lead investigator, Karim Fizazi, presented a chart comparing the overall survival in men originally diagnosed with high volume (≥4) distant metastases and treated with both medicines. Their overall survival increased more than with either alone. https
I promised I'd update this as more info came in. The lead investigator, Karim Fizazi, presented a chart comparing the overall survival in men originally diagnosed with high volume (≥4) distant metastases and treated with both medicines. Their overall survival increased more than with either alone. https
Tall_Allen
in
Advanced Prostate Cancer
3 years ago
Neutrophil:Lymphocyte Ratio [NLR] in patients with mCRPC treated with Cabazitaxel v. Abiraterone or Enzalutamide in the CARD study
{"ARTA" is shorthand for
abiraterone
or enzalutamide - both target the AR axis.} What is a high NLR in this study?
{"ARTA" is shorthand for
abiraterone
or enzalutamide - both target the AR axis.} What is a high NLR in this study?
pjoshea13
in
Advanced Prostate Cancer
3 years ago
Update after a year on vacation
in hope others can learn from my experience Background: DX April 2018 PSA 23 Gleason 9 Pet CT PSMA SCAN April 20 2018: Bones clear, visceral organs clear ,uptake in prostate escaping the capsule + few pelvic lymph nodes. inoperable May 2018 started Lucrin (after two weeks of bicalutamide) joined by
Abiraterone
in hope others can learn from my experience Background: DX April 2018 PSA 23 Gleason 9 Pet CT PSMA SCAN April 20 2018: Bones clear, visceral organs clear ,uptake in prostate escaping the capsule + few pelvic lymph nodes. inoperable May 2018 started Lucrin (after two weeks of bicalutamide) joined by
Abiraterone
dorke
in
Advanced Prostate Cancer
3 years ago
Abiraterone and heart issues
I've been on Zytiga 1000mg since last February. This week I went in for my second stress test....this time an ECG with ultrasound. They apparently have found something called LBBB...left bundle branch block. It's a delay of electrical impulses on the left side of the heart. I know that Zytiga can
I've been on Zytiga 1000mg since last February. This week I went in for my second stress test....this time an ECG with ultrasound. They apparently have found something called LBBB...left bundle branch block. It's a delay of electrical impulses on the left side of the heart. I know that Zytiga can
bean1008
in
Advanced Prostate Cancer
3 years ago
For those of you still working with advanced PCa, and on ADT and Radiation. Did you still work a full schedule?
Currently on Lupron,
Abiraterone
, Prednisone with Radiation to start in 2 weeks. I am still working but need lots of time for appointments every week and radiation has not begun yet. I have a fairly big role and am not sure I can give it what it needs. I welcome your thought and guidance.
Currently on Lupron,
Abiraterone
, Prednisone with Radiation to start in 2 weeks. I am still working but need lots of time for appointments every week and radiation has not begun yet. I have a fairly big role and am not sure I can give it what it needs. I welcome your thought and guidance.
Johnson411
in
Advanced Prostate Cancer
3 years ago
Abiraterone Abroad?
Hi everyone, Being a UK NHS patient, it looks as though after chemo, my dad will have ran out of options after chemo as the NHS won't offer
abiraterone
as he has already had Enzalutamide beforehand. He has liver mets so won't be able to have ra 223 either.
Hi everyone, Being a UK NHS patient, it looks as though after chemo, my dad will have ran out of options after chemo as the NHS won't offer
abiraterone
as he has already had Enzalutamide beforehand. He has liver mets so won't be able to have ra 223 either.
Hillwalker87
in
Advanced Prostate Cancer
3 years ago
What will be the effects of transitioning from Bicalumatide plus the shot in the buttocks to Abiraterone and prednisone etc
Doctor transitioning from Lupron and the butt shot, to
Abiraterone
/prednisone et al..... what can I expect?
Doctor transitioning from Lupron and the butt shot, to
Abiraterone
/prednisone et al..... what can I expect?
Jeremiad53
in
Advanced Prostate Cancer
3 years ago
Bone Resorption Inhibitor + Abiraterone - Overall Survival
Results: Of the 745 men (median age, 77.6 years [interquartile range, 68.1-83.6 years]; 699 White individuals [93.8%]) included in the analysis, 529 men (71.0%) received
abiraterone
acetate with prednisone alone (
abiraterone
acetate cohort), and 216 men (29.0%) received
abiraterone
acetate with prednisone
Results: Of the 745 men (median age, 77.6 years [interquartile range, 68.1-83.6 years]; 699 White individuals [93.8%]) included in the analysis, 529 men (71.0%) received
abiraterone
acetate with prednisone alone (
abiraterone
acetate cohort), and 216 men (29.0%) received
abiraterone
acetate with prednisone
pjoshea13
in
Advanced Prostate Cancer
3 years ago
Starting Abiraterone & Prednison 5mg - advice?
Starting
Abiraterone
as soon as it arrives. Any thoughts on what to expect? Side effects? Thanks in advance. Side note for what it is worth: I have been vaccinated and tested positive for COVID last Thursday, these past 4 days have been brutal, but I feel much better today.
Starting
Abiraterone
as soon as it arrives. Any thoughts on what to expect? Side effects? Thanks in advance. Side note for what it is worth: I have been vaccinated and tested positive for COVID last Thursday, these past 4 days have been brutal, but I feel much better today.
Johnson411
in
Advanced Prostate Cancer
3 years ago
6 monthly update and potential treatment questions
He was put on ADT (Leuprolide and
Abiraterone
). Looking at his age and health chemo is not an option. After 6.5 months his PSA is down to 1.2 and fresh CT comparison states the following: "[i]Prostatic lesion shows decrease in size and PSMA uptake (approx. 20% decrease in size).
He was put on ADT (Leuprolide and
Abiraterone
). Looking at his age and health chemo is not an option. After 6.5 months his PSA is down to 1.2 and fresh CT comparison states the following: "[i]Prostatic lesion shows decrease in size and PSMA uptake (approx. 20% decrease in size).
Rodeoz15
in
Advanced Prostate Cancer
3 years ago
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