This does NOT apply to men who have been treated with chemo or a second-line hormonal agent for newly diagnosed hormone-sensitive PCa (mHSPC), or any who have previously had chemo or any second-line hormonal agent as part of a previous therapy.
It DOES apply to men who have progressed to metastatic castration-resistant PCa after previous prostatectomy and primary or salvage radiation, and are chemo and second-line hormonal naive.
The surprise is that Lynparza works so well in combination with abiraterone. It has been previously found to not work well as a single agent unless there is a BRCA mutation.
There are ongoing clinical trials of Lynparza or other PARP inhibitors in combination with other medications (e.g., chemo, radiopharmaceuticals, immunotherapies).
The benefit is in radiographic progression-free survival. No numbers yet.
As you write: "No numbers yet". If 10% of the study cohort had a BRCA mutation, which is what you should expect, you will get a better result compared to the control group when adding Lynparza. This will probably be significant.
No, you misunderstand. They stratified on whether men had defects in homologous recombinational repair (HRR) of DNA genes (like BRCA+) and found that both groups responded better to the combination than to abi alone. That's why this is so practice-changing.
There have been so many presentations, articles and discussions about the new personalized medicine based on Olaparib. Seems all this can be ditched when the results of the PROpel study will be published.
So, I am on Zytiga, Orgovyx, and predisone and have non-detectable PSA and no gene mutations. What does this mean to a lot of us? Should I switch over to the combination of Zytiga plus Olaparib for longer lasting results? Thanks for your thoughts.
My father was part of this trial with Zytiga (abiraterone) +/- Lynparza (olaparib). He tested negative for BRCA mutations. It was a double blind study meaning that we didn’t know if he was receiving olaparib or a placebo. However, his oncologist suspected he was actually on olaparib because of some of the blood markers. His cancer is very aggressive and the oncologist thinks this is what kept his cancer in check for a year rather than the abi by itself.
Well it does not mean “You don’t know what you think you know about chemo.” (joking!)😆. Actually it just means you have not had prior chemotherapy. That your cancer has not been exposed to it yet.
Best thing I have read in a long time! Olaparib was shown to likely work for my based on my genetics and is being held until needed. Currently on Zytiga. Can't wait to see this data presented and discuss with my oncologist at my next visit.Thanks for all of your sharing!
Recently I posted that I was really sick from Cabazytaxel or Covid booster.Well maybe the timing is the reason, but side effects are gone: garlic did it!
2 meals of Bagels with a lot of tzatziki and regularity was restored .
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It now Seems indisputable that therapies in combination with ADT are better than ADT alone
Immunotherapy Clinical Trial or Olaparib (Lynparza)?
De Novo Oligometastatic - Undetectables Please
