This is a repost from a PBC patient on the Yahoo forum. It got me thinking about different brands of URSO and their effectiveness. I'm interested in any feedback because I've been on a "generic" URSO for 8 months with no change. My alk-phos fluctuates but has never normalized. Thanks, Stella
I was diagnosed in 2011 and had been on the same brand ever since - with ALP returning to normal after only 3 months on Urso. My insurance/mail order pharmacy changed last year and I started receiving a generic brand I had never heard of (and I've heard of many, since I facilitate a local support group). ALP started going up and up and up and my doc wanted to put me on Ocaliva. I put that off as long as possible - and I actually asked him about different brands - if that could be the case (he had never heard of that happening). Well, low and behold, insurance changed again in July and I got new Rx in August and it was the old brand I had been on since day 1. Less than 30 days on old brand and ALP was dropping! I'll get checked again in a couple months and we'll see if it's still dropping. If so, I will be TOTALLY convinced that it was the other brand that was not working.
And IF that is the case, it really upsets me! You get a generic brand "assuming" ; they all have the same active ingredients, but I'm not so sure that really is the case. I can see "fillers" causing side effects, but can't understand how "fillers" would change the efficacy of the actual main ingredient. Also, if this is the case, I will be making sure that my Drs specify the generic brand that I know works for me.
Julie in TX(53), PBC diag 2/2011, most likely stage 1 (per fibroscan 5/2017)