Recently, someone posted on here, that they were @ the PBC conference in Las Vegas. They heard the last doctor that spoke, state that Urso does what its going to do, in the first 5 years of taking it. Does anyone know how long Urso works? My hepatologist which is also the liver transplant director, said to me that Urso helps most PBC patients, but once it stops working, that is when they come see him. Until that happens, their health can be managed by a gastroenterologist. I was sort of shocked when he made that statement & never questioned it further, however, I have thought of it a lot since.