I wanted to share my experience in case it helps.
2 years ago, I had routine blood work done so that I could refill my blood pressure medication and the doctor said my liver enzymes were high. He kind of brushed it off and recommended that we wait and test again in 6 months to see if they are still high.
A year and a half ago, I returned for blood work and my liver enzymes were still high. So, the doctor ordered an ultrasound of the liver and everything turned out fine. No problems.
1 year ago, I had to have a laparoscopic hysterectomy (I was in a lot of pain and had developed uterine fibroids). My pre-operative blood work showed my liver enzymes were elevated. The surgeon went ahead with the surgery, and she examined my liver while she was removing my uterus. She said it looked perfect.
I had been fatigued for years, but I thought it was due to my inflamed uterus. I was rather surprised to see that all my symptoms were relieved by the hysterectomy, all except for horrible fatigue. It is very difficult for me to maintain my weight and nearly impossible to lose weight.
About 6 months ago, I followed up with a new doctor as my liver enzymes have been high for a really long time now. And I still have the issue of fatigue. The new doctor ran my blood test results and said that the liver enzymes AST and ALT were high. She referred me to a Gastrointestinal specialist.
My specialist ran a huge blood panel on me and ordered an ultrasound. My liver enzymes AST (113, normal is <40) and ALT (170, normal is <32) were elevated, serum Ferritin (219, normal is <150) was elevated, and I tested positive for Mitochondrial (M2) Antibody (118.8, positive is anything over 24.9). My liver ultrasound showed fatty deposits consistent with fatty liver disease and spots, the largest of which is 1.3 cm on the right lobe. My specialist ordered an MRI and he wants to see me in the office as soon as the results are ready. He suspects fatty liver disease and possibly PBC. We will discuss whether or not to do a biopsy after we see the MRI results.
Now that I look back, I do have several symptoms that could be due to PBC or some kind of liver dysfunction: fatigue, itchy palms, sensitivity to gluten and other difficult-to-digest foods and sometimes vomiting right after eating them, swollen and tender abdomen, light colored stool, yellowing of the skin especially around the eyes (this comes and goes), xanthalasma cholesterol deposits under my eyes, sometimes trouble concentrating...
Any thoughts would be appreciated. A diagnosis has not been confirmed yet.