Clinical Trial with Abemaciclib and Olaparib

[TealBlooms]

Hey Queens!

I am reaching out to see if anyone is participating in this clinical trial. I am having a hard time deciding if this is a “favorable” option for me. I’d love to get some type of feedback from an actual patient. It’s fairly new, so any findings seem impossible to come by.

Also, I’d love to connect to anyone who is close in age to me. I was diagnosed in 2021, at the age of 42, with Stage IV Ovarian Cancer. My CA125 at that time was 2200. I had a total abdominal hysterectomy in addition to chemotherapy with Taxol/Carboplatin, then Zegula for maintenance. My CA125 dropped down to 11, but 4 months later at my checkup, that number shot up. Legions were found at the back end of my colon, on my liver, and on my psoas muscle. I then started on Doxil to no avail. My oncologist then recommended Gemzar, which isn’t working as well. I had my last dosage today…

[delia2]

Hi. I see no one has answered yet. I’m neither young nor in that trial, but it sounds like it’s a good bet for you. One question is whether it’s double blind and therefore you might not get the drugs—pretty risky in your situation— or whether you know you’ll get the drugs? I assume you’re in the UK and I’m pretty sure Elahere isn’t available there but I would also get tested to see if that would be appropriate for you and then seek some kind of special exception to try it. See if it’s in any trials there( generic name mirvetuxemab something). If not contact the manufacturer. Also if you’re not at a top cancer center please seek a second opinion from one.

[TealBlooms in reply to delia2]

Hey Delia!

The trial that is offered is an oral therapy taken for 28 days and requires 3 biopsies.

Never heard of Elahere, but I will look into it! Thank you.

I’m actually in the US.

[Lyndy]

Hi Tealblooms, you have had quite a roller coaster ride! I am sorry that you aren’t having much luck with chemo.

Regarding the trial, I have recently been on another trial drug with Olaparib. The team that treated me took a great deal of care to ensure that they were offering me a good option which fitted with my situation and level of disease. They are then backed up by the sponsor of the trial who is looking at results across the world and offers further advice on whether the drug is right for each patient.

Therefore, if you are offered a trial it will be because it is a good option for you, not just because they want to test out their product.

I would go with whatever the trial researchers say xx

[TealBlooms in reply to Lyndy]

Hey Lyndy!

Thanks for responding! The trial that is offered is an oral therapy taken for 28 days and requires 3 biopsies - not at all enticing. I am my Oncologist’s youngest patient, so in all honesty, sometimes I feel like . . . well, I won’t say it. It’s just so hard to figure out what’s best for me and which treatment to go with.

[Cheka123 in reply to TealBlooms]

how do you get on a trail can you ask i understand some of it but not all

[Leniko]

Gemzar didn’t do much for my psoas tumor either. Ask about immunotherapy Opdiva & Yervoy. Good Luck.