Good morning lovely ladies, I just wanted to post this here for anyone else who was/is searching for answers and driving themselves nuts like I was, about what happens next after a severe allergic reaction to Paclitaxel. Don't give up hope!
A short summary of what's happened to me:
Debulking op: 20th March 2017
Diagnosed OC Stage 3a with grade 3 cells: 30th March 2017
Chemo started: 11th May 2017
I was due to have the usual Carboplatin / Paclitaxel combination, but had a severe anaphylactic reaction to the Paclitaxel within the first minute of infusion, so it was stopped. Due to this it was then decided that it was unsafe for me to try it again, so cycles 2, 3 and 4 went ahead with Carboplatin only. Pre op my CA125 was 2380, when I started chemo my CA125 was 151, but during cycles 2, 3 and 4 it gradually increased each time till it was 200. For cycle 5 my oncologist decided to try a sister drug to Paclitaxel called Taxotere in addition to the Carboplatin. Unfortunately I also had a severe anaphylactic reaction to this within the first 5 minutes, so it had to be stopped again and I had just Carboplatin once more. After that one my CA125 went up to 234. For cycle 6, my oncologist decided to do a desensitisation /desensitization process where they put in small amounts of the drug at a time and manage any small reactions as they go along, I agreed to go ahead and we tried it at the end of August - it went in!!! They managed to get my body to accept it doing it this way! 6 months from my operation, 6 cycles of chemotherapy and two anaphylactic reaction later, but with perseverance on both my oncologists and my part, it happened.
The last few weeks have been a bit grim in terms of side affects, but yesterday was the day to go and find out the results of blood tests to see if it's all been worth it - IT WAS!!! CA125 down from 234 to 132. We (me and hubby) are absolutely delighted and I just wanted to share the fact that there is hope for anyone going through the same.