First time posting here. Good luck to everyone in their battle with this malignancy!
After finding cysts in her ovaries my wife's ca125 was found to be at 823. She had her debulking surgery Feb 23rd 2017. She was staged at 3C with high grade serous ovarian cancer. Tumors along with ovaries, tubes and uterus and mets on intestine, diaphragm and stomach resected.
Chemo started on March 23rd 2017. CA125 was 465 before the 1st infusion.
1st cycle: Taxol and Carboplatin. However Taxol couldn't be administered due to severe reaction. 18 days later CA 125: 76
2nd cycle April 13th: Taxotere and Carboplatin. 19 days later CA125=18
3rd cycle May 5th: Taxotere and Carboplatin with Neulasta OnPro (she was neutropenic after 2nd cycle) 18 days later ca125=49
Her Ca125 showed a nice decline after the first and the second infusion but after the 3rd infusion we saw a jump back up to 49. We are utterly disappointed. We'll see if this is a trend when we get her next blood draw before her fifth infusion on jun 16. If it keeps rising I guess they will change the meds from carbo-taxotere to something else? I hope this was a one of rise due to cancer cell death or other inflammation in her body. I hope her cancer is not platinum refractory.
Has anybody had this kind of rise after a meaningful drop in ca125? Could cancer become resistant just after 2 cycles of chemo?