Vitamin D and Aspirin working

[Tranquility1]

In 5 months of taking 5000 i.u. of Vitamin D-3 a day, I went from a blood test of Vitamin D 25 Hydroxy of 19.7 ng/ml to 30.6. The normal range is 30 - 100. My doctor would like to see that number go much higher than that low threshold of 30. It's a slow move up, but it's working. Hooray!

Good news the aspirin therapy of 2 baby aspirins (one morning and one evening) is bringing my Prothrombin Fragment 1+2 down. Hooray! Prothrombin Fragment 1+2 is a huge indicator of being in a hypercoagulable state. I am ALWAYS above the 325 pmol/L threshold showing my body is always ready to form clots. Since my doctor did the aspirin blood test to see that I can handle more aspirin and then increased me to two baby aspirins a day -- this is the first time I haven't tested high on the Prothrombin Fragment 1+2 EVER (in years). In fact today, I was normal at 240 pmol/L. Hooray - the two baby aspirins are working.

My Factor XI activity is 133%. For people with levels above 120.8% (90th percentile), they have a 2.2 increased risk of deep vein thrombosis. While a 2.2 increased risk doesn't seem high, every elevated risk adds up. "High levels of factor XI are a risk factor for deep venous thrombosis, with a doubling of the risk at levels that are present in 10 percent of the population." nejm.org/doi/full/10.1056/n...

My serum Calcium has gone up without taking any Calcium supplements. My doctor said that is due to the Vitamin D-3 supplement. He said most people don't need calcium, but instead they need Vitamin D.

My platelets are high (which increases the risk of clotting). In addition, my cholesterol is high which also coupled with normally being hypercoagulable makes people clot more easily. My doc wants my LDL below 100 mg/dl. Today it came back as 146 mg/dl. Not good. He believes anyone who is hypercoaglable should have LDL cholesterol below 100.

My doctor forgot to put on the lab request the iron tests I have been waiting for. Ughhhh. Next round of tests.

Summary from my doctor for me: Keep taking vitamin D, keep taking the baby aspirins, eat better and lose weight. If only it was that easy. 3rd day of migraine. I skipped walking on the treadmill today, knowing it would make the migraine worse.

[Tranquility1]

Here is the study regarding Prothrombin Fragment 1+2 and Antiphospholipid Syndrome. I am not sure why more doctors don't do the easy blood test for Prothrombin Fragment 1+2. It gives a good indication of how hypercoagulable someone with Antiphospholipid Syndrome is as any given moment.

"Prothrombin fragment 1 + 2 measures treatment effect in patients with antiphospholipid syndrome.

Abstract

Antiphospholipid syndrome (APS) is characterized by recurrent thrombosis. The anticoagulant management of APS thrombosis remains controversial. Few reports on markers of in vivo activation of coagulation have been reported. To determine whether plasma levels of prothrombin fragment 1 + 2 (F1 +2) correlate with thrombotic risk and treatment effect in patients with APS, plasma F1 + 2 levels were followed in 57 patients with this syndrome for more than 2 years. Clinical findings were also observed in these patients. Plasma levels of F1 + 2 in patients with APS were significantly higher when compared with control subjects (p<.05). These results suggest patients with APS are in a hypercoagulable state. Plasma levels of F1 + 2 significantly decreased following treatment with either aspirin, or aspirin plus warfarin (p<.05 and p<.01, respectively). Recurrent thromboses or spontaneous abortions occurred in all eight patients whose plasma levels of F1 + 2 remained higher than 1 nmol/l after treatment with either aspirin alone or no anticoagulants. These patients were subsequently treated with warfarin as well as aspirin, and plasma levels of F1 + 2 decreased to less than 1 nmol/l, with no additional thrombotic events over the remainder of the 2-year follow-up. No fatal bleeding was observed in treated patients. Our results suggest plasma levels of F1 + 2 are useful indicators of successful treatment. It is also suggested that warfarin plus mini-dose aspirin therapy is effective for patients with APS to protect from recurrent thromboses without harmful side effects. Further, prospective cohort studies are needed to substantiate these associations." ncbi.nlm.nih.gov/pubmed/973...

[Manofmendip]

Hi.

I'm curious that you are still suffering with intractable migraines but it seems that your Dr has not tried you on a trial of Fragmin (Low molecular weight Heparin). When I was first diagnosed I had terrible migraines, which were not stopped with anti-platelet medication (Aspirin and Plavix), which Prof Hughes tried me on at first. When these did not improve my symptoms he trialed me on Fragmin and this stopped my migraines and many other symptoms so he moved me toy Warfarin. My migraines were kept a bay for 7 years and then, strangely, returned.

My neurologist added Amitriptyline 20mg and my migraines stopped again. Prof Hughes moved me back onto Fragmin, from Warfarin, and maybe I could now try stopping the Amitriptyline but I'm not that brave. lol

Who is managing your APS and where are you from?

Best wishes.

Dave