"Men who underwent prostate biopsy between January 2005 and December 2015 were retrospectively analyzed. The association between lipid profile and the risk, stage, and Gleason grade group (GG) of the PC were investigated."
"Of the 1740 study populations, 720 men (41.4%) were diagnosed as PC."
"Univariate quartile analysis founded serum triglyceride increasing risk of locally advanced disease than organ confined disease. (OR: 1.00, 1.25, 2.04, 4.57 for 1st, 2nd, 3rd and 4th quartile"
The triglycerides: HDL-cholesterol is a surrogate for insulin resistance. Too bad they didn't look at that too (they had the data).
"Conclusions: This study findings suggested increased in triglyceride level increased the risk PC. Increased in triglyceride level also associated with aggressive presentation of PC, with higher stage and GG."
Yes, I was thinking of testosterone too. After my testosterone cypionate shot, triglycerides drop to about 50. After 3 months of ADT, they go to >150. Oddly, my HDL-cholesterol rises too. The latest tests (May 8) show a ratio of 179:154!
The subjects in the study had not yet been diagnosed with PCa, so none were on ADT, of course. I expect that some had low T & elevated triglycerides.
179 was triglycerides; the HDL-C was 154. Still crazy, though.
Here is my cholesterol breakdown:
HDL-C = 154
LDL = 12
VLDL - 36
Total-C = 202
Another thing that happens on ADT: LDL goes down while VLDL goes up. VLDL is the bad one. Nothing good happens on ADT (except PSA going down). I'm looking forward to my next testosterone vacation, starting July 1st.
Really interesting study. My husband has familial high cholesterol and high triglycerides. He started on lipitor at around 28 and was diagnosed with PC at 51. His dad died from PC at the age of 72. Had he not been on a statin for all of those years, I wonder how different things could've been for him at diagnosis.
His post RP gleason score was 3+4 =7. Tumor volume was 20% with <5% of the tumor volume was pattern 4 and no adverse findings on the pathology.
Almost same here. Familial hypercholesterolemia type A (total C -350 without drugs). Have been on and (mostly) off of statins since my early thirties. Does your husband have high Testosterone as well?
Consider checking Apo-B and Apo-a for a better picture. If you won’t do a statin then discuss a PCSK9 inhibitor, though both is best. It is not a valid “pass” IMO to die of ASCVD while fighting APC, though it is quite a common occurrence in our population.
I have been taking a combo of 20 mg Atorvastatin + 10 Ezetimibe continuously for the past 4.5 years. I have noticed that all my lipid numbers have gradually gone down after starting low dosage of Bicalutamide. My before and present numbers are:
Actually, his testosterone has been on the lower range of normal, it's definitely not high. It was checked about a year ago, at the same time his PSA came back elevated. I don't remember the number.
Insulin resistance with associated dyslipidemia is a long term inflammatory condition which is a key driver of cancer progression via the Hallmarks of Cancer. Possible explanation for these results and wake-up call for optimal management. Statins also have anti-inflammatory effects. Paul
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Long-Term Adverse Effects and Complications After Prostate Cancer Treatment - JAMA Oncology, Nov 7, 2024 - w/ SWOG commentary
