c-myc

[pca2004]

Further to the "Supraphysiological Androgens [SPA] Promote Tumor Suppressive Activity of the AR Through cMYC Repression and Recruitment of the DREAM Complex" thread, here's a handful of papers of interest.

[1] Metformin & c-myc

[2] 5-LOXIN & c-myc

[3] Sulforaphane & c-myc

[4] Honokiol & c-myc

-Patrick

[1] ncbi.nlm.nih.gov/pmc/articl...

[2] ncbi.nlm.nih.gov/pmc/articl...

[3] ncbi.nlm.nih.gov/pmc/articl...

[4] ncbi.nlm.nih.gov/pmc/articl...

[PhilipSZacarias]

This may suggest that taking metformin or sulforaphane while doing BAT may be beneficial. Cheers, Phil

[pca2004 in reply to PhilipSZacarias]

Hi Phil,

Turns out that I have been doing all four.

Happy Canada Day!

Best, -Patrick

[PhilipSZacarias in reply to pca2004]

Well, I’ll be darned. I know it’s quaint but sounds right. I should have expected that…and your success with BAT. Cheers, Phil

[hansjd in reply to pca2004]

Hi Patrick

Can you tell me in what form you take sulforaphane and honokiol? Thanks Gail

[pca2004 in reply to hansjd]

Hi Gail,

I splurged on my last sulforaphane purchase:

amazon.com/gp/product/B08JG...

since I am concerned about bioavailability.

For honokiol, I went down-market:

swansonvitamins.com/p/swans...

"(standardized to minimum 90% honokiol + magnolol)"

-Patrick

[hansjd in reply to pca2004]

As always, thanks Patrick. I've now added these two sups. Already had the other two. 😊 Cheers Gail

[PCaWarrior]

Which MYC inhibitor is fda approved?

However, amongst all the US Food and Drug Administration (FDA)-approved targeted therapies for MYC-dependent cancers, the only inhibitors that exploit vulnerabilities of MYC, are those of mTOR (everolimus, sirolimus, and tesirolimus) and of IMPDH (mycophenolic acid)

I take 2 mg of sirolimus once weekly. I am going to up that to 5 mg during high T and leave at 2 mg during low T.

[cigafred in reply to PCaWarrior]

Seems an immunosupressant like sirolimus could do more harm than good, particularly for those of us trying to encourage our immune systems to fight PCa (layman's view)?

[PCaWarrior in reply to cigafred]

High dose = immunosuppressive. Low dose = immuno supportive. FDA approved c-Myc inhibitor and mTOR inhibitor. "On November 22, 2021, the FDA approved sirolimus protein-bound particles for injectable suspension (albumin-bound) (brand name Fyarro) for adult patients with locally advanced unresectable or metastatic malignant perivascular epithelioid cell tumor."

I don't use the suspension. I toggle between 2 and 5 mg once weekly. PSA seems to react. However, I use it as part of a BAT regimen.

Some people use it stand-alone. I don't know how effective it is stand-alone. Also, it inhibits anabolism on the day it is used. But it increases fat reduction. Some bodybuilders use it for that purpose.

[cigafred in reply to PCaWarrior]

Thank you.