Cytokine inhibitors and immune modulators

[PCaWarrior]

Thoughts? MateoBeach Opinion? I recall you were using curcumin and maybe some others?

Drug/Therapy (Mechanism / Status)

Sipuleucel-T (Autologous dendritic cell vaccine; approved)

Pembrolizumab (PD-1 checkpoint inhibitor; approved for MSI-high)

Ipilimumab (CTLA-4 checkpoint inhibitor; experimental in PC)

Nivolumab + Ipilimumab (PD-1 + CTLA-4 combo; experimental)

Thalidomide (Immunomodulator targeting TNFα, IL-6; off-label/experimental)

Lenalidomide (Immunomodulatory analog of thalidomide; experimental)

Siltuximab (Anti–IL-6 monoclonal antibody; experimental)

Tocilizumab (Anti–IL-6 receptor antibody; in trial)

Carlumab (Anti–CCL2 chemokine antibody; experimental)

Corticosteroids (e.g., Dexamethasone or Prednisone; anti-inflammatory glucocorticoids; standard use)

High-Dose Vitamin D₃ (10,000 IU/day with Vitamin K₂ [MK-4 & MK-7]; natural supplement; experimental)

Doxazosin (α₁-adrenergic blocker; used for hypertension/BPH; theoretical cytokine inhibition)

Prazosin (α₁-adrenergic blocker; used for hypertension/BPH; theoretical cytokine inhibition)

I'm looking for one that might lend itself to

BAT + olaparib + darolutamide + orgovyx + SBRT