I don’t know what the risk/reward ratio is but something that a person at high risk of PCa might consider. When my kids get a little older I’m going to talk to them about this. We have lots of data. This is just one clinical trial.
Prevention of PCa using dutasteride.
clinicaltrials.gov/study/NC...
This makes sense in a way, and is counterintuitive in a way... Like my dad used to say "on the one hand... but on the other hand....". Drove my mom crazy. He was never wrong.
It is great that they are thinking about prevention. My concern is, what is being proposed to help prevention for those aged 40 - 50. More and more young people are being diagnosed. I'm very concerned for my son's aged 29 and 27 as I was diagnosed at 53.
Have you asked your doctor? Frequent PSA and DREs are probably still needed. Catch it early and, well, I didn't catch it early...
I'm going to try to do some kind of risk/reward analysis on dutasteride. It's cheap and easy to get. But do the preventive benefits for someone at high risk justify the side effects? I don't know that answer. My oldest is 18 and I was diagnosed at 55 and his grandfather on his mother's side was diagnosed at 68 and died of PCa.
Just did a little research.
Avg man has about a 13% chance for PCa diagnosis.
Dad has cancer: inc 2.1x
Dad and a grandfather has cancer: inc 3.5x
So, my oldest has almost a coin flip chance. I'll be talking to him.
Top parenting sir, it's a conversation I need to have, will be harder than telling my son's about my diagnosis I think. Chris Hoy the British cyclist knew that his grandfather and father had pc but was not offered early testing at any point and very sadly he was diagnosed stage 4, advanced prostate cancer at his initial diagnosis. I'm adopted so do not know my family history. I have to assume that my father had it.
I'm a strong supporter of Dutasteride as an alternative modality for treating PCa.
In my case (N=1), 5 months of Dutasteride monotherapy reduced my PSA from 10 to 2.4.
I think it is underused. It doesn't have great efficacy. But it's cheap and has very few sides. A few months of dutasteride might be able to keep your cancer in check and then delay CRPC a little.
It's bigger than that...MRI measurements show that PCa tumors shrank by 30% over 6 months of dusteride treatment, compared to a 20% increase in tumor size when treated with a placebo. That's significant!
Estimating the Number of Men Living with Metastatic Prostate Cancer in the United States
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