I have been taking 5htp from holland and barret for the last two months and have noticed an improvement in my energy levels and I'm not feeling as depressed as I was. I take on in the morning and one at night. I have also found they help me to fall asleep easier, sleep deeper and for longer. I have tried so many other supplements but nothing has worked 'till now. Still looking for something to help with the pain, one day I hope that will ease too, I live in hope!