amino acids not recognised as essential in humans such as taurine play a role in fibromyalgia,

[LawrenceT]

In this study, researchers measured the level of 20 amino acids (critical components of proteins). They found that overall levels of amino acids were lower in fibromyalgia and that seven amino acids were especially low, including taurine, alanine, tyrosine, valine, methionine, phenylalanine, and threonine.The pattern of amino acid deficiency was especially suggestive of a problem with the sympathetic (adrenaline) nervous system, which tends to be overactive and then exhausts in patients with CFS and fibromyalgia.Amino acids are critical for many functions, especially the production of key brain chemicals called neurotransmitters. I recommend supplementation with all of the amino acids as opposed to using a single one by itself, as these supplies overall nutritional support and are less likely to cause a relative deficiency of other amino acids. Although some excellent physicians use amino acid testing, I'm still not convinced of its necessity or validity, and prefer to simply have people with fibromyalgia eat a high-protein diet and supplement with amino acids. A good multivitamin powder should include a decent amount of amino acids. Eggs are also an excellent protein source.

vitality101.com/health-a-z/...

[LawrenceT]

Aside from the retina, every region of the brain that has been tested contains or takes up taurine; this includes the pineal [22,23], pons medulla [24], hypothalamus [25], striatum [26], and cerebellum [27,28]. At each of these sites, there is evidence of taurine’s ability to ameliorate certain forms of neuropathology.Because it is one of the few amino acids not used in protein synthesis, taurine is often referred to as a “nonessential” amino acid, or more generously as a “conditionally essential” amino acid. Considering its broad distribution, its many cytoprotective attributes [29,30], and its functional significance in cell development, nutrition, and survival [31,32], these are clearly misnomers. Taurine is undoubtedly one of the most essential substances in the body. Moreover, there is ever-increasing evidence that taurine depletion leads to a wide range of pathological conditions

ncbi.nlm.nih.gov/pmc/articl...

[desquinn Partner Volunteer FMAUK Trustee]

Really like Jacob and some of his approach to fibro. Do not agree with his overly dependant supplement approach but the "body blowing a fuse" is a great analogy for fibro. He is a great guy to chat to as well.

This study is really small and Jacob's site tends to rely on small pilot studies for their basis of approach. Just like with D-ribose it appeared to help a small group but really unclear about how much is placebo as you do not have long term data.

Backsplaining in fibro is really common. The body does this with that hormone or whatever to this explains fibro and you should take more or less. It is faulty logic and with any supplements they should address a need and this should be assessed through testing and then the right corrective dose should be done to address the need. Otherwise you send up excreting expensive pee.

But do your point about a healthy diet. Without fibro or with it a healthy diet will be more healthy.

[Gooddaysagain in reply to desquinn]

I got to the same conclusion about Amino Acid, by starting with the question: " why does Duloxetine, an SSNRI, work for me? ". This took me to the hormones on which SSNRIs are designed to have an effect, and the need for protein and a healthy gut to create these ourselves. Most people with Fibro and/or CFS have some form of difficulty digesting and assimilating sufficient protein to build the hormones necessary for a healthy 'pain management system '.

Once I'd come off all my Fibro-specific meds, I did a gentle detox. Then I started taking a full-spectrum Amino Acid, with additional Taurine and the B and C vitamins necessary for a chemical reaction. I also added Tyrosine and Tryptophan to support my mental and immune health.

I still take codeine for acute/chronic pain, but am no longer on Tramadol, or the many SSRI/SSNRI and other stronger meds I used to take, and which never really worked for Fibro pain.

I'm glad I asked that question and did my research. The 4 months it took to come off my meds and replace them with a high protein diet and Amino Acid supplements was a tough time, but it's been worth it.

I slip from time-to-time; it takes money and discipline, and I don't have much of either. Then I start going downhill again and remember I can be in control of how I feel.

I hope this new research helps more people.

Kind regards, Dee

[Colourpink66]

hi Lawrence I’m interested in your review on amino acids, any recommendations for a multi version of them

[Rainbowangel]

Thank you Lawrence