Meds interaction-Duloxetine


I have seen my GP consistently over the last few weeks. Why?

I feel more and more tired! No indicators on blood tests.

They have zeroed in on my meds. I have taken some for years and never felt very tired.

Trialled Fluoxetine but side affects crazy.

Was on Citalopram cannot take Anytripteline.

Now been given Duloxetine.

However, researched on meds interaction site . I take codeine as main pain killer and this has reactions with said Duloxetine.

So anyone taking the two together and what are your thoughts?

By the way GP says Duloxetine is recommended for Fibromyalgia anyone heard that before?

11 Replies

  • I'm in duloxtine for fibromyalgia as well as depression.

  • There are a few meds that show up as contraindications when taking another, but if your GP is aware of this then they will have taken it into consideration when prescribing any meds. Your pharmacist will pick up on it if there is a problem. I'm on Citilopram and Amitrypteline which the books say shouldn't be taken together, but because of why I am prescribed them then it is safe. Hope that helps settle your concerns, even if just a little 🐸

  • Yes I take doluxertine for fibro, it took me quite a few weeks to get used to, now on 120mg a day amongst other meds xx

  • Hi I am on duloxetine - just that - they took me off pregabalin because of the weight gain -x

  • i was on duloxetine, but felt horrible on them 120mg silly me stopped taking them and o my goodness, withdrawals was horrific. I would never take them again.I was on citalopram and amitriptyline which was good but felt a bit stale mate,thats why i was put on duloxetine, but am back on citalopram with view to introduce amitriptyline back again.

  • I was on Pregablin and 30/500 mg cocodamal and was out in Duloxotine to try and help with sleep and the lower back pain but the Duloxotine had such bad side effects I had to stop taking it after a few weeks. Yes my GP said it was one of the antidepressants they recommend for fibro it has been in the USA since about 2008 so seems to be a well established fact. Hope this helps.x

  • thanks to all those who have replied . I will suck it and see. GP said just give it just over a week as I had bad sensations with Fluoxetine which is same family as Duloxetine.

  • Hi guys, can I also add to thread that there is a moderate interaction risk from taking Codeine products and Pregabalin at the same time also. I have pasted an excerpt from the * website relating to this risk:

    *Interactions between your selected drugs


    codeine ↔ pregabalin

    Applies to:Tylenol with Codeine #3 (acetaminophen/codeine) and Lyrica (pregabalin)

    Using codeine together with pregabalin may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

    All my hopes and dreams for you


  • Here here Ken, should maybe highlight Do not stop using medications without first talking to your doctor. For numpties like me 😖😖. Hoping you are well Ken take care 🤗

  • Thanks my friend. I also question the way some doctors tell us to come of medications? he! he! :)

  • Duloxetine is recommended for fibromyalgia and licenced in some countries for this indication.

    Duloxetine and codeine are perfectly safe to my knowledge, it's tramadol and antidepressants that aren't in combination that safe.

    Clearly combining medications acting on the CNS has the potential to make you more tired and drowsy initially. To me this is to be expected and not a danger.

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