Hi does I have been prescribed duloxetine for pain , also have terrible anxietyand wake every morning in a dreadful state shaky and trembly, does anyone know if and how long they take to work and inital side effects, as I feel very tired all the time....I am to start on 30 mgs and increase to 60 mgs after 2 weeks. I am also worried if they don't suit, effects of withdrawal. I am very stressed at the thought of taking them. I have only tried amitriptyline, but felt so bad only too it for 2 days. Hope for some advice please.